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Biomedical subjects

B S Aron

Publications and source records attributed to B S Aron.

At least 37 records · Page 2Linked to original sources
PubMed1986

Comparison of whole pelvis versus small-field radiation therapy for carcinoma of prostate.

One hundred thirty-six patients with adenocarcinoma of the prostate gland Stage A2 (12 patients), Stages B1 and B2 (26), Stage C (64), and Stages D1 and D2 (34 patients) were evaluated clinically and treated in a similar fashion at three hospitals. Megavoltage radiation therapy units were employed to deliver 4,600-5,000 cGy to the whole pelvis, and the prostatic area was treated for an additional 2,000 cGy (boost). Local recurrence was infrequent (8/136 = 6%), and the five-year actuarial survival and disease-free survival rates were 85 and 42 per cent, respectively. Adverse clinical parameters included poor histologic differentiation, age younger than sixty years, and diagnosis by transurethral resection of the prostate rather than needle biopsy in Stage C patients. Severe acute reactions occurred in only 2 patients, and only 2 patients were hospitalized for severe chronic (late) reactions. Whole pelvis radiation yielded a statistically significant improved five-year survival and three-year disease-free survival for similarly evaluated patients for Stage C but not for Stages A and B when compared with 116 patients treated with small-volume radiation (prostate area), previously reported from these three hospitals.

Adenocarcinoma↗
PubMed1985

Radiation-associated gliomas: a report of four cases and analysis of postradiation tumors of the central nervous system.

Four cases of radiation-associated gliomas are described. All patients were white men, irradiated in childhood for craniopharyngioma, anaplastic ependymoma, retinoblastoma of the orbit, and Burkitt's lymphoma, respectively. The dose ranged from 1800 to 5900 rads, and the latency period was 5 to 25 years. All primary and secondary tumors were verified histologically, and no evidence of persistence of the primary tumors was found. All secondary tumors arose in the fields of irradiation. Ninety-six cases of radiation-induced tumors of the central nervous system have been reported in the literature to date. Twenty-four were gliomas and occurred mainly in young men.

Adolescent↗
PubMed1984

Secondary renal osteogenic sarcoma 14 years after primary therapy.

We excised a left renal osteogenic sarcoma 14 years after curative therapy for a primary tumor of the left ulna and 2 years after resecting a solitary pulmonary metastasis. This large renal neoplasm was recognized because it concentrated abnormally large amounts of technetium during a radionuclide bone scan.

Adult↗
PubMed1981

Imaging of irradiated liver with Tc-99m-sulfur colloid and Tc-99m-IDA.

In three cases, irradiated regions of liver failed to concentrate Tc-99m-sulfur colloid. In two of these three, imaging with Tc-99m-acetanilide iminodiacetic acid (IDA) agents within five days showed near normal hepatic uptake of this hepatobiliary imaging agent. The hepatic parenchymal cells may be imaged with Tc-99m-IDA in some irradiated regions of liver, despite loss of reticuloendothelial cell function.

Aged↗
PubMed1978

Generation of iso-TDF maps: considerations for radiation therapy planning.

The NSD (nominal standard dose) concept has been useful in therapy for comparing various radiation treatment schedules. More recently, TDF (time, dose, and fractionation) factors were introduced. By incorporating treatment schedules (time and fractionation) with isodose summations, TDFs can be determined throughout the patient contour, including tissue in and outside the tumor volume. For this purpose an isodose summation program was modified to generate iso-TDF maps based on the treatment schedule. For schedules in which all fields are not treated every day, recovery is not inhibited throughout the total treatment volume. It was necessary to reevaluate the concept of "recovery time" for tissues outside the tumor volume and to introduce a "threshold to inhibit recovery" model. Clinical examples assuming this recovery model are presented.

Cobalt Radioisotopes↗
PubMed1977

Radiation-induced bladder tumors.

A recent 25-year experience with patients treated for carcinoma of the uterine cervix who subsequently had bladder tumors is presented. Of the 3,091 patients treated 2,674 had received radiotherapy and 8 suffered vesical malignancies of varied histopathological type 6 months to 20 years after irradiation. This incidence rate is 299.9 per 100,000, which is 57.6 times that of the general female population. Benign radiation reactions of the bladder and the possible etiology of radiation-induced bladder cancers are discussed.

Adult↗
PubMed1976

Rhabdomyosarcoma in children. A clinicopathologic study of 35 patients.

Thirty-five patients with rhabdomyosarcoma were treated at the Children's Hospital Medical Center from 1953 to 1973. Factors important in diagnosis and prognosis included age, sex, site, stage of tumor, and specific pathologic type. Effects that surgery, radiation, and chemotherapy had on survivals were also analyzed. Survivals ranged from 2 to 20 years. The rates were 86% for Stage I disease; 40% for Stage II disease, and 0 for the more advanced lesions. A useful prognostic indicator was found in pathologic subgroupings. Survivals for the myxoid spindle-cell variant were 80% for all stages. For the partial maturation series with moderately well-differentiated rhabdomyoblasts, survival was 10% for all stages. For a combination of the above two types, survival was 40% for all stages. The alveolar types had no survivors, although these patients seemed to live longer with their disease.

Adolescent↗