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Biomedical subjects

B S Bell

Publications and source records attributed to B S Bell.

5 recordsLinked to original sources
PubMed2001

Conducting industrial and organizational psychological research: institutional review of research in work organizations.

Although informed consent is a primary mechanism for ensuring the ethical treatment of human participants in research, both federal guidelines and American Psychological Association ethical standards recognize that exceptions to it are reasonable under certain conditions. However, agreement about what constitutes a reasonable exception to informed consent is sometimes lacking. We presented the same protocols to samples of respondents drawn from 4 populations: Institutional review board (IRB) members, managers, employees, and university faculty who were not members of IRBs. Differences in perceptions of IRB members from the other samples with respect to the risks of the protocols without informed consent and on the feasibility of conducting the research in employment organizations are discussed in terms of implications for industrial and organizational psychology research.

Administrative Personnel↗
PubMed2000

A bayesian analysis for spatial processes with application to disease mapping.

In epidemiology, maps of disease rates and disease risk provide a spatial perspective for researching disease aetiology. For rare diseases or when the population base is small, the rate and risk estimates may be unstable. We propose using a Bayesian analysis based on the conditional autoregressive (CAR) process that will spatially smooth disease rates or risk estimates by allowing each site to 'borrow strength' from its neighbours. Covariates may be included in the model in such a way as to establish a possible association between risk factors and disease incidence. Bayesian inferences are implemented from a direct resampling scheme where large samples are generated from the various posterior distributions. The methodology is demonstrated with a simulation that assesses the effect of sample size and the model parameters on inferences for the parameters. Our approach is also used to spatially smooth district lip cancer rates in Scotland using the CAR model with a covariate that allows for exposure to sunlight.

Bayes Theorem↗
PubMed1995

Green fluorescent fusion proteins: powerful tools for monitoring protein expression in live zebrafish embryos.

The recent development of transgenic technology in zebrafish has opened an exciting new avenue in which to explore vertebrate development. However, as in other species, the inability to easily identify live transgenic fish severely limits the potential of this promising technology. To determine whether the recently described green fluorescent protein (GFP) might provide a convenient live staining method in zebrafish, we constructed a glutathione S-transferase/GFP fusion protein (GST-GFP). GST-GFP cRNA, when injected into individual blastomeres of early zebrafish embryos, resulted in the rapid development (3 hr) of easily detectable green fluorescence which persisted for up to 4 days. GFP fluorescence was restricted to progeny of the injected cell and appeared to have no adverse effects on embryonic development despite widespread expression. Our findings demonstrate that GFP fusion proteins will provide a simple yet powerful means of monitoring production of heterologous proteins in live zebrafish.

Animals↗