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Biomedical subjects

B S Briskin

Publications and source records attributed to B S Briskin.

At least 19 recordsLinked to original sources
PubMed2000

[The immunological aspects of predicting antibiotic therapy efficacy in peritonitis patients].

The analysis of the impact of various group antibiotics on the mechanisms of development and correction of pathogenetically heterogeneous immune deficiency in 235 patients at age of 17 to 85 years with local (80 patients) and general (155 patients) peritonitis is presented. Cephalosporins and fluoroquinolones promoted restoration of the immune and interleukin (IL-1 and IL-2 of donors, IL-1r and IL-2r of patients) status and lowered the immunodepressive effect of glucocorticoids (GC) at the organism (cortisol, ACTH and cortisol-binding globulin) and cellular (GC receptors III) levels. Aminoglycosides and penicillins had no significant action on the immune and interleukin status but lowered the EG effect at the organism (aminoglycosides) and cellular (penicillins) levels. It is recommended that the antibiotics be used with an account of their involvement in the systemic reactions of the host.

Adolescent↗
PubMed2000

[A trial of using augmentin (amoxicillin/clavulanate) in surgical practice].

The experience with the use of augmentin (amoxycillin/clavulane) in abdominal surgery for prophylaxis of postoperative purulent complications was analyzed. The drug was used in 44 patients after relatively pure operations, 37 of them having various risk factors. In 2 patients (4.5 per cent) of that group postoperative pyoinflammatory complications were recorded. For comparison the results of the prophylactic use of cefoperazone, cefamandole or ceftazidime in the group of 78 patients after relatively pure operations on the abdominal cavity organs were analyzed. Postoperative complications in the latter group amounted to 7.4 per cent (4 patients). The results of the treatment of patients in two groups after contaminated operations were also compared. The patients of one group (41 patients) were treated prophylactically with augmentin in a dose of 1200 mg intraoperatively followed by the drug use in a dose of 600 mg thrice daily for 1 to 2 days after the operation. Postoperative pyoinflammatory complications were recorded in 4 patients of that group (9.7 per cent). 78 patients of the other group were treated prophylactically with ceftazidime or cefoperazone in a dose of 2 g and metronidazole intraoperatively or cefoperazone in a dose of 2 g twice daily and metronidazole in a dose of 500 mg twice daily for 1 to 2 days after the operation. Postoperative infectious complications were recorded in 8 patients of that group (10 per cent). In the group of patients with acute cholecystitis treated with ciprofloxacin in a dose of 400 mg in combination, with metronidazole before the operation and for 1 to 2 days after the operation postoperative complications were recorded in 4 patients (17 per cent).

Abdomen↗
PubMed2000

[Immunostimulating activity of eubiotic bioflor in intestinal dysbacteriosis of various origin].

The data are reported on novel eubiotic biofor's effects on immune status of 213 patients with intestinal dysbacteriosis (39 surgical gastroenterological patients, 43 patients with diarrheal infections, 50 AIDS patients, 81 cancer patients exposed to radiation and chemotherapy). It was found that bioflor acts as an antidysbacteriosis drug and as an immunostimulator. It stimulates T-cell immunity, phagocytosis, B-cell immunity. Immunostimulating effect of bioflor depends on dysbacteriosis degree and is maximal at its first stages.

Adolescent↗
PubMed1999

[Occlusive ileus in colonic cancer].

The experience of treatment is available for 404 patients with mechanical obstruction in cancer of the colon. Clinicoroentgenological and ultrasound examinations of the organs of abdominal cavity provided early diagnosis of the disease. Radical operations were carried out in 59.7% of the patients, palliative ones--in 40.3%. Radical right-sided hemicolectomy was completed by creation of ileotransversoanastomosis, in left-sided hemicolectomy it was obligatory to take out both ends of the resected colon (if it is possible technically and later restoration of its continuity is planned), or the operation of Hartmann type was performed. The operation should be completed in bowel decompression by nasointestinal intubation. It should be used the term "resolved" or "unresolved" bowel obstruction after the performance of conservative measures, and the term "partial bowel obstruction" should not be used as it presents formulation of treatment policy and may be the cause of undue delay of the operation.

Adult↗
PubMed1999

[Treatment of diabetic foot complications].

Of 3721 patients with diabetic lesions of the foot treated 2416 (65%) patients have been operated. The rise of urgent hospitalization rate (over 90%) unfavourably influenced the results of the treatment and contributed to increased frequency of high amputations of the extremity. The proposed system for evaluation of the condition and scope of the combined treatment resulted in decrease of mortality among operated patients from 14.7% to 9.8% and among not operated ones--from 20.5% to 5.5%. The suggested classifications of complicated forms of the "diabetic foot" syndrome provided proper evaluation of the prognosis and individual approach to the choice of treatment measures.

Aged↗
PubMed1997

[Extracorporeal lithotripsy in combination with endoscopic papillotomy in choledocholithiasis].

Results of treatment of 30 patients of 50 to 90 years of age having choledocholithiasis by the method of extracorporeal lithotripsy (EL) combined with endoscopic operations on the major duodenal papilla are described. The first stage in the treatment was endoscopic papillosphincterotomy. There were 41 sessions of EL (at an average 1,37 procedure for each patient). In 15 patients spontaneous excretion of the fragments from the common bile duct was noted. The endoscopic sanitation of the common bile duct with a removal of fragments with the Dormia basket was fulfilled in 13 patients after EL. The method of choledocholithotomy proved to be ineffective in 2 patients. Sanitation of the common bile duct was performed in all the patients before their discharge from the hospital. Thus the results obtained allow considering the extracorporeal biliary lithotripsy when combined with endoscopic papillosphincterotomy as an effective method for treatment of patients with choledocholithiasis which not only supplements traditional surgical procedures but also may be used as an alternative method of treatment especially for patients with high operative risk.

Aged↗
PubMed1996

[The relationship of the treatment results in acute pancreatitis to the correctness of the diagnosis of the stages of the disease].

An analysis of 77 case histories of people who died from destructive pancreatitis is presented. Medico-tactical errors and complications were found out. A differentiated approach to treatment of acute pancreatitis was shown to be necessary depending on the stage of the disease. Preference is given to complex conservative therapy with the closed-type little-invasive operations. The total amount of patients with acute pancreatitis for the period under analysis is 1644. Postoperative lethality was 46%, total lethality--4.7%.

Acute Disease↗
PubMed1996

[Therapeutic interventions under ultrasonic control in diseases of the abdominal cavity organs].

The results of 212 transcutaneous therapeutical abdominal interventions, performed under the ultrasound control, have been analysed. 190 patients have been treated. The sectorial ultrasound probe was acting at the frequency of 3 MHz. The electronic matrix guided the needle. One-stage percutaneous drainage with an "umbrella" stylet catheter was used in all cases. Percutaneous drainage of the gallbladder was performed in 140 patients; 111 of them had acute cholecystitis with a high surgical risk. The operation of cholecystectomy has been performed in 32 patients after control of the acute stage of the disease. In 47 patients percutaneous drainage was indicated in case of liver cysts and abscesses, intraliver hematomas, liver pseudocysts, liver pseudoabscesses, abdominal abscesses. These types of curative procedures have limited contraindications, can be performed irrespective of the patient's condition, and in certain cases may be an alternative to major surgical interventions.

Abdomen↗
PubMed1995

[Acute cholecystitis as a problem of laparoscopic surgery].

The article deals with experience in 89 operations of laparoscopic cholecystectomy in patients with acute cholecystitis aged 17 to 82 years. A total of 92 attempts were made, 3 patients underwent laparotomy. Forty-five patients had catarrhal, 35 phlegmonous, and 9 gangrenous cholecystitis. In the preoperative period 37 patients were subjected to endoscopic retrograde pancreaticocholangiography, endoscopic papillosphincterotomy was performed in 28 of them, in 9 the operation was complemented by nasobiliary drainage. As a result intraoperative cholangiography had to be conducted only in 3 patients. Intraoperative complications developed in 42 and postoperative in 18 patients (local in 15 and general in 3). There were no fatal outcomes.

Acute Disease↗
PubMed1991

[Magnetic-laser irradiation of the liver in the treatment and prevention of hepatic insufficiency in mechanical jaundice].

The effect of magnetolaser irradiation on the liver in obstructive jaundice was studied in experiments on 500 rats. Magnetolaser irradiation was found to have a favourable effect on the functional morphology of the liver; it levels many morphological signs of hepatic insufficiency and thus provides the grounds for carrying out an operation on the bile ducts under optimal conditions. The suggested method of magnetolaser therapy was applied in 142 patients with hepatic insufficiency in obstructive jaundice. The study showed that magnetolaser therapy applied in complex treatment of hepatic insufficiency promotes active restoration of the function of the organ, significantly raises the efficacy of treatment, and reduces the term of the patient's hospital stay.

Adult↗