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Biomedical subjects

B S Hansen

Publications and source records attributed to B S Hansen.

45 records · Page 3Linked to original sources
PubMed1979

Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy.

The antiepileptic effects of carbamazepine and phenytoin were compared in a double-blind crossover trial studying patients with primary and secondary generalized seizures and partial seizures with motor symptoms. Each treatment period lasted ten weeks. The patients were seen every two weeks, and doses were adjusted according to plasma levels. It was attempted to keep levels in the optimal plasma range, ie, 10 to 20 and 4 to 10 mg/liter for phenytoin and carbamazepine, respectively. Twenty-three patients entered and 19 completed the study. No statistically significant differences were found between carbamazepine and phenytoin with regard to seizure control and acute side effects.

Adolescent↗
PubMed1977

Interaction between carbamazepine and propoxyphene in man.

This investigation was carried out because of a clinical suspicion of drug interaction between Propoxyphene (PRX) hydrochloride and Carbamazepine (CBZ). Seven out-patients, six suffering from epilepsy and one from trigeminal neuralgia, treated with CBZ alone or in combination with phenobarbitone, received PRX hydrochloride capsules, 65 mg three times a day. Two patients stopped the PRX intake after 2 days due to severe side effects. Three of the remaining patients had symptoms and signs of drug intoxication. Blood samples were examined by thin-layer chromatography. A marked increase (45-77 per cent) in CBZ plasma level was found in all patients on combined treatment of CBZ and PRX. There were no significant changes in CBZ-10,11-epoxide level. The results suggest an inhibition of CBZ metabolism when CBZ and PRX are administered simultaneously.

Adolescent↗
PubMed1974

Mechanism of action of the mycotoxin trichodermin, a 12,13-epoxytrichothecene.

Trichodermin is a member of a group of closely related compounds-the 12,13-epoxytrichothecenes-that form a medically and economically important class of mycotoxins produced by fungi that spoil fruit and grain. Our studies show that trichodermin is a very potent inhibitor of protein synthesis in mammalian cells. Since ribosomes remain in polyribosomes in inhibited cells, trichodermin inhibits the elongation and/or termination processes of protein synthesis. In vitro, trichodermin is a potent inhibitor of the peptidyl transferase activity required for elongation and/or termination. An in vitro comparison of the effects of three peptidyl transferase inhibitors on elongation and termination indicates that anisomycin acts primarily on elongation while trichodermin and sparsomycin act primarily on termination. A new in vivo test to distinguish elongation inhibitors from termination inhibitors confirms that trichodermin inhibits primarily the termination process. Thus trichodermin inhibits protein synthesis by blocking the activity of peptidyl transferase required for termination. These studies suggest that the toxicosis caused by one of the 12,13-epoxytrichothecenes is due to its action as a protein synthesis inhibitor involving the peptidyl transferase activity of the eukaryotic ribosomes.

Amino Acids↗
PubMedDate not supplied

Incidence of stroke in Frederiksberg, Denmark.

Since 1971, stroke registers in several countries have been cooperating in a study of stroke epidemiology, initiated by WHO. One of the registers covers the population of Frederiksberg, Copenhagen. During the first two years of registration strokes were recorded in 556 Frederiksberg citizens. A certain diagnosis of cerebral hemorrhage--verified by angiography, spinal fluid examination, or autopsy--was made in 10% of the patients; subarachnoid hemorrhage was demonstrated in only 2%; most of the remaining patients probably had cerebral infarction. The overall annual incidence of stroke, when adjusted for age for the Danish population, was 1.9 per 1,000 for males, and 1.6 per 1,000 for females. For every type of stroke, except subarachnoid hemorrhage, the incidence increased markedly with age. The age-specific stroke incidence rates found in the present investigation are much lower than those demonstrated by Aho in a community-based study in Finland. In view of the strict comparability of the two studies, real differences in the risk of stroke may exist between the two communities.

Aged↗