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Biomedical subjects

B S Khyshiktuev

Publications and source records attributed to B S Khyshiktuev.

At least 19 recordsLinked to original sources
PubMed2005

[Ventramine and lipid peroxidation in children with erosive gastroduodenitis].

43 patients and 20 healthy children, aged 11-15, were examined. Increased contents of primary, secondary, intermediary and final products of lipid peroxidation (LPO) in serum lipids as well as an intensified antioxidant activity were registered in children with erosive gastroduodenitis. Ventramine, when used in the treatment of erosive gastroduodenitis in children, arrests rapidly the clinical signs of the disease and normalizes LPO.

Adolescent↗
PubMed2005

[Fatty acid constitution of the lachrymal fluid in healthy subjects and in patients with ophthalmopathology].

The relative content of higher fatty acids (FA) was studied in lachrymal fluid of 10 virtually healthy subjects and of 9 patients with maculodystrophy aged 30 to 40. The FA methyl ethers were assayed with the "Chrystall-2000 M" gas chromatograph. The content of C(15:0), C(15:1), C(16:0) and C(16:1) as well as the content of such oversaturated FA as C(18:3omega6) and C(20:4omega6) was found to be decreased in patients with macoludystrophy. Simultaneously, a higher level of FA with a longer carbon chain (C(17:0), C(18:0), C(18:1), C(18:3omega3) and C(20:3omega6) was registered in these patients. The results testify to changes in the composition of lachrymal fluid in ophthalmopathy and point out the expedience of further research in the discussed field.

Adult↗
PubMed2004

[Changes in lipid peroxidation in psoriasis].

Changes of the lipid peroxidation processes (LP) in the skin (corneal layer of the epidermis) and in blood, as observed in 61 patients with local psoriasis at the progressing stage and in 55 patients with local psoriasis at remission, were investigated. The quantity of diene conjugates, ketodienes, and of conjugate trienes in the heptanoic and isopropanol phases was decreasing both in the affected and intact skins versus the controls. The test based on thiobarbituric acid (TBA) was used to establish that the content of the TBA-positive products was also decreasing. The examined values did not reach the control figures at remission. The content of the studied indices in blood was reliably higher than the control figures in all lipid extract phases at exacerbation of the dermal affection; it did not decrease after the main dermal lesion was eliminated. The correlation analysis revealed the presence of correlations between the studied parameters in blood and skin, which were changing with respect to a stage of the dermal affection.

Adult↗
PubMed2004

[The level of lipid peroxidation products and the parameters of antioxidative defense in the expired air condensate in patients with respiratory tuberculosis].

The paper presents the data of examination of three groups of patients with pulmonary tuberculosis: 25 with a relatively favorable course of the disease, 26 with acutely progressive tuberculosis, pneumoperitoneum along with chemotherapy was used in complex therapy in 10 of them. The parameters of lipid peroxidation were estimated in the condensate of the expired air from patients before and 3 months after inpatient therapy. Irrespective of the type of the course of the disease, patients with tuberculosis were found to have a marked increase in the elimination of lipid peroxidation products, as well as deficiency of antiradical defense factors, which also preserved after therapy. The use of pneumoperitoneum in the complex therapy of patients with acutely progressive tuberculosis reduced the level of lipid peroxidation products more significantly.

Adult↗
PubMed2002

[Hormonal correction in combined therapy of temporomandibular joint dysfunction in women].

Pain dysfunction syndrome of the temporomandibular joint (TMJ) in women is often accompanied by mammary and reproductive disorders associated with endocrine disturbances. 30 female patients aged 19-35 years suffering from of the pain dysfunction syndrome TMJ combined with intact dentition and orthognathic occlusion were studied. Dental examination was followed by gynecologic examination. According to the treatment the patients were divided into 2 groups. Group I included women who were administered conventional treatment (orthopedic treatment, drug and physiotherapy). In group II patients conventional therapy was also combined with monophase oral contraceptive "Femoden". Efficacy of treatment in group I was 46.67%; while group II patients showed a 100% favourable effect. Besides, combination of dental and gynecologic therapy was found to exert a 2.1 times more stable clinical effect us compared to conventional treatment. Hormone correction in women with reproductive pathology results in prolonged control of the pain dysfunction syndrome TMJ due to steroid normalization (hypothalamic, hypophysial, ovary steroid normalization) and has no side effects.

Adult↗
PubMed2001

[Steroidogenesis disorders in women with temporomandibular dysfunction].

The aim of the study was to trace hormone shifts in women suffering from different manifestation of the TMJ pain dysfunction syndrome. Levels of some blood steroid hormones (oestradiol, progesterone, testosterone, cortisol) were determined in 193 female patients aged 14-70. The object of study was blood serum collected in different menstrual phases. It was found that when pain dysfunction syndrome of the TMJ was accompanied by intact dentition and orthognathic occlusion blood steroid levels demonstrated shifts since puberty. In pain dysfunction syndrome of the TMJ accompanied by occlusal disharmony steroid shifts were first registered an early reproductive age. In patients without pain dysfunction syndrome of the TMJ steroid values remained close to those of healthy control. Shifts in steroid production may be indicative of impaired steroidogenesis in women with pain dysfunction syndrome of the TMJ.

Adolescent↗
PubMed2000

[Fatty acid composition of lipids in lung tissue of patients with lung cancer].

The fatty acid (FA) spectrum of lung tissue fragments was studied versus distance of malignant cells from lesion focus in lung cancer patients. Decreased polyunsaturated FA levels in all samples were attributed, chiefly, to linoleic, (linoleic-new) and eicosatrienoic acid deficiency. Both in tumor tissue and areas of intensive cell proliferation, accumulation of monounsaturated C18:1 and C15:1 fatty acids, low C20:4(6 and C 20:5(3 and an FA with 19 carbon atoms were detected. The total concentration of (-6 and (-3 series fatty acids was relatively low, too, the deficit of the latter being remarkably low. Those changes are likely to be related to certain peculiarities of the structure and functions of tumor cells.

Adult↗
PubMed2000

[Lipid peroxidation processes in epidermis of patients with psoriasis].

The evaluation of local peroxide status was studied in 42 patients with psoriasis depending on the disease stage in different age periods (from 18 to 67 years) with disease duration from 2 months to 20 years. It was established that the development of psoriatic process is accompanied with the marked changes in local peroxide status in the epidermis. It is manifested by the decrease in intensity of lipid free-and-radical oxidation. Decrease in the products of lipoperoxidation occurs in epidermis--both in the affected and intact areas in all investigated patients independently of the stage of psoriatic process. It is more expressed during the aggravation period. The minimal levels of the intermediators being studied are recorded in the psoriatic plaques.

Adolescent↗
PubMed1998

[Prenatal diagnosis of fetal hypoxia based on lipid peroxidation values in exhaled air condensate].

Lipid peroxidation values were measured in the serum and expired air of pregnant women. The levels of diene conjugates, secondary intermediates of free-radical processes, and malonic dialdehyde were increased in exhaled air condensate of pregnant women who gave birth to babies with grave hypoxia, as against women with healthy babies or babies with slight hypoxia. All the studied values were more demonstrative in the expirate than in the serum. Hence, grave fetal and neonatal hypoxia can be diagnosed before delivery by examining the exhaled air condensate of pregnant women.

Apgar Score↗
PubMed1996

[The body's antioxidative systems in bronchopulmonary disease].

A comprehensive study was made of the parameters of antioxidative defense in patients with chronic nonspecific pulmonary diseases (CNSPD), malignant and benign respiratory tumors. The highest deficiency of antioxidants both in blood and lung tissues were noted in CNSPD patients. With malignant tumors, the level of radical inhibitors depends on the stage of malignancy and the histological pattern of a tumor. There were correlations between the studied parameters in the blood and cytoplasmic fraction of lung tissue in cancer patients. It is suggested that redistribution of antioxidative resources occurs in the body in adenocarcinoma and small-cell carcinoma.

Adenocarcinoma↗
PubMed1996

[The effect of surgery on free-radical reactions in patients with lung cancer].

The effect of surgery on free-radical reactions in patients with lung cancer was studied vis-a-vis extent of intervention. To this end, blood components and exhaled air condensate were monitored. Surgery was found to aggravate the imbalance in the "lipid peroxidation-antioxidants" system in those operated on. The data obtained make a case for application of antioxidants in complex treatment of lung cancer. Said parameters were evaluated versus incidence of early postoperative lung-pleura complications. Preoperative criteria for prognosis of postoperative complications have been worked out.

Adult↗
PubMed1993

[Changes in lipid peroxidation and phospholipid spectrum of blood in patients with lung cancer].

The parameters of the lipid peroxidation - antioxidants system, phospholipid profile, erythrocytes and blood plasma of 47 patients with lung cancer were studied. Serious disturbances in phospholipids profile in cases of central and peripheral lung cancer were identified. They included a decreased phosphatidycholine level, accumulation of lysophospholipids and appearance of phosphatidyglyceral fraction in blood plasma. Those shifts occurred alongside with enhanced lipid peroxidation and a deficit of antioxidation protection factors.

Adult↗
PubMed1990

[Indices of lipid peroxidation in the condensate of exhaled air--a simple and objective method of estimating injuries to the pulmonary surfactant system].

A method for assessing injury to the pulmonary surfactant system is suggested, based on studies of lipid peroxidation parameters in exhaled air condensate. Free-radical processes in pulmonary surfactants were examined in normal subjects and in patients with various forms of chronic nonspecific diseases of the respiratory organs. The findings evidence that a disease essentially intensifies lipid peroxidation in the alveolar lining, this being parallelled by reduced antiradical defense. Such an approach to studies of pulmonary surfactant system injuries is marked for its simplicity and atraumatism, this recommending it for mass clinical check-ups. Use of this method is promising as regards the disease prognosis and assessment of the treatment efficacy, as well as detection of subjects at high risk of developing bronchopulmonary diseases.

Adult↗
PubMedDate not supplied

[Phospholipid composition of various parts of the involved organ in lung cancer].

Phospholipid spectrum of lung tissue fragments was studied in the dependence on the presence of malignant cells located at different distance from the focus of affection. Elevation of sphingomyelin (SM) level and lowering of phosphatidylcholine (PC) was noted in all analyzed patterns in pulmonary tissue. Alteration of growth malignant fields with extensive necrosis zones predominated in the same simples. The accumulation of phosphatidylinositol (PI) fraction and phosphatidylglycerol (PGL) deficiency was found. A similar tendency was supplemented with lysophosphatidylcholine (LPC) maximum on line of the extensive growth. It might be the result of invasive characteristic manifestation by tumor cells.

Adenocarcinoma↗
PubMedDate not supplied

[Diagnostic value of the determination of fatty acid spectrum of expired air condensate in the workers of coal stripping].

The fatty acid spectrum of an expired air condensate was studied in the workers of the Kharanor coal stripping and in the dwellers of Chita (a control group). Regularities in the changes of the expired air fatty acid profile were assessed by the degree of exposure to coal dust and by the length of service. The findings indicated the relationship of profile changes with the degree of exposure to occupational noxious agents: the proportion of saturated fatty acids decreases much more significantly in workers who were directly exposed to the dust than in those were indirectly done. It is concluded that the fatty acid composition of an expired air condensate adequately reflects the changes occurring in the respiratory system upon exposure to dust.

Adult↗
PubMedDate not supplied

[Effects of complex therapy with emoxipin on the course of diabetic retinopathy].

The efficacy of 1% emoxipin solution (eye drops) in the nonproliferative stage of diabetic retinopathy was studied. The inhibition of lipid peroxidation and an enhancement of antioxidizing guard were observed both after the therapy by the above preparation and 3 months later. It was concluded that emoxipin was effective for leveling the biochemical violations in the "lipid peroxidation--antioxidants" system of lachrymal fluid in patients with the nonproliferative stage of diabetic retinopathy. The prescription of emoxipin eye drops can enhance the efficacy of therapy at the early stages of the disease.

Antioxidants↗
PubMedDate not supplied

[The status of free radical processes in the pulmonary surfactant system in chronic bronchitis patients].

Lipid peroxidation-antioxidants were studied in condensed expired air of patients with chronic bronchitis. Under conditions of bronchopulmonary system impairment considerable activation of lipid peroxidation occurred in surface-active lung layers. These processes were elevated during development of the bronchial obstruction syndrome. Alterations of lipid peroxidation were amplified in patients with chronic bronchitis as functional impairments of the respiratory system increased. The antiradical defense system of lung surfactant was found to correlate inversely with the disease duration and severity of respiratory insufficiency.

Adult↗