PubMed Health⌕ Search

Biomedical subjects

B S Mackie

Publications and source records attributed to B S Mackie.

At least 19 recordsLinked to original sources
PubMed1999

The PABA story.

The qualities of para-aminobenzoic acid (PABA) are discussed and an account is given of how it came to be the favourite sunscreen of the post World War II era. Slowly, however, dermatologists became aware that it was a fairly common sensitizer and that it tended to cross-sensitize with compounds of similar chemical structure both in contact with the skin and given as systemic drugs. Furthermore, continued exposure to chemicals of this type could lead to autoimmune responses especially systemic lupus erythematosus and dermatomyositis. Discussion of these complications from the use of PABA took place at two meetings of the Dermatological Association of Australia in 1964 and 1965, and played a part in the slow withdrawal of PABA from sunscreens.

4-Aminobenzoic Acid↗
PubMed1987

Melanoma and dietary lipids.

Samples of subcutaneous adipose tissue were taken from 100 melanoma patients and 100 matched controls in Sydney in 1984-1985 and were analyzed for constituent fatty acids. The mean percentage of linoleic acid in the triglycerides of the subcutaneous adipose tissue (PLASAT) of these subjects was substantially higher than that in a similar group examined in 1975-1976. In addition, the percentage of polyunsaturated fatty acids was found to be higher in the melanoma patients than in the controls (p less than 0.01), and there were significantly more controls than patients who had a low PLASAT (p less than 0.01). Relevant literature is quoted and the suggestion is made that increased consumption of dietary polyunsaturates may have a contributory effect in the etiology of melanoma.

Adipose Tissue↗
PubMed1980

Bile duct adenocarcinoma with Leser-Trelat sign and pure red blood cell aplasia.

A case of adenocarcinoma of the bile duct complicating longstanding ulcerative colitis and associated with the rapid onset and growth of multiple seborrheic keratosis (Leser-Trelat sign) and pure red blood cell aplasia is described. This is the first report of a case of the coexistence of the Leser-Trelat sign and pure red blood cell aplasia in a patient with a malignancy. Both manifestations have been doubted as truly paraneoplastic manifestations because of their rarity in clinical medicine. Their co-existence in the present case would support their associaton with malignancy.

Adenocarcinoma↗
PubMed1980

Dietary polyunsaturated fats and malignant melanoma.

The consumption of polyunsaturated fat of a group of patients with malignant melanoma was compared to that of various groups of control subjects to determine whether such dietary fats predispose to the development of malignant melanoma. The results are tabulated with reference to various associated factors, and a statistical assessment of their significance is presented. The writers were unable to agree on the interpretation of the results, and present two opposing views on whether the ingestion of polyunsaturated fat is associated with the incidence of malignant melanoma.

Adipose Tissue↗