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Biomedical subjects

B S Moore

Publications and source records attributed to B S Moore.

27 records · Page 2Linked to original sources
PubMed1979

Protease inhibitor variants in children and young adults with chronic asthma.

The results of systematic medical histories and pulmonary function tests on 26 children and young adults, 10 with Pi variant alpha1-antitrypsin phenotypes and 16 Pi normals, are reported. These subjects were selected from 57 consecutive patients who had chronic asthma. The incidence of Pi variants was 20.4% among 46 Caucasian subjects (ages seven to 21 years). The Pi variant patients required more bronchodilators and long-term corticosteroid therapy. Among the parents and siblings, 50% of those with abnormal Pi type had chronic obstructive lung disease. Grandparents of the Pi abnormal probands had greater incidence of chronic obstructive lung disease (P less than 0.05). Baseline specific airways conductance and maximal midexpiratory flow rates did not discriminat between the two groups. However, bronchodilator inhalation showed the Pi variant group to be significantly less responsive than the Pi normal group. Pi heterozygous state, particularly Pi MZ, should be considered when a young person with chronic asthma is unresponsive to adequate doses of bronchodilators and needs prolonged use of corticosteroids.

Adolescent↗
PubMed1978

Hypersensitivity to milk and egg white. Skin tests, rast results and clinical intolerance.

Prick tests to milk and egg white were compared to clinical histories of sensitivity to these foods. Seventeen RAST-positive versus 17 RAST-negative controls were used. All 34 children and young adults were selected because they had atopic respiratory and/or dermal manifestations. Atopic eczema manifestations were present in 11 of the RAST-postive subjects and in two of the controls. Of these, nine had past history of egg white intolerance. Egg white challenge was associated with dermal reactions as follows: eczema in two, urticaria in two and angioedema in two. Positive clinical histories compared favorably (p less than 0.001) with prick tests for egg white but poorly (p greater than 0.05) for milk. Similarly, positive clinical histories compared significantly (p less than 0.001) with RAST for egg white but poorly (p greater than 0.05) for milk.

Adolescent↗
PubMed1978

Chronic rhinitis in the pre-school child.

The etiologic role of atopy in chronic rhinitis in 40 infants and pre-school children was investigated and the long-term effectiveness and safety of promethazine studied during six to 48 months. Twenty children were clearly atopic and 16 were not. Four had incomplete laboratory evidence of atopy. In addition to clinical histories and physical findings, the subjects were evaluated by skin tests for common allergens. RAST tests, total IgE levels and absolute eosinophil counts. Promethazine in doses of 3 to 12 mg/kg/day (mean 8 mg) was administered in divided doses, four times a day for perennial rhinitis and on "as required" basis for recurrent and seasonal rhinitis. Side effects included drowsiness and irritability, which led to discontinuance of promethazine in one subject. There was no laboratory evidence of hematologic, renal or hepatic abnormalities. Promethazine was found to be an effective agent for symptom-control of chronic rhinitis in the pre-school child.

Asthma↗
PubMed1977

A comparative study of allergens of canine origin.

Among 115 children and young adults studied, 52 had current and 25 had past household exposure to dogs, totaling 77 subjects. Of 53 with clinical hypersensitivity to dog, 32 had a history of exposure, 34 positive cutaneous reactions and 15 RAST positive results. Of 62 without clinical hypersensitivity, 45 had a history of household exposure, 24 positive cutaneous reactions and 6 RAST positive results. Cutaneous tests were not done on seven individuals. The major type of clinical symptomatology to dogs was ocular and nasal, 40 of 53. Thirty-two of 53 patients developed asthma exacerbations alone, or in combination with other manifestations, upon dog exposure. Dermal reactions were urticaria is six and contact eczema in two subjects. RAST inhibition results suggested that in vitro testing may be more useful when allergens from specific dog breed extracts are characterized.

Adolescent↗
PubMedDate not supplied

Transcatheter manipulation of asymmetrically opened titanium Greenfield filters.

PURPOSE: The problem of asymmetric opening of the modified hook titanium Greenfield inferior vena cava filter necessitating transcatheter manipulation was evaluated in a retrospective study. PATIENTS AND METHODS: Titanium Greenfield filters were placed in 166 patients over a 36-month period. The radiographic reports of all patients were reviewed to identify cases in which the filter failed to open symmetrically after deployment and catheter or wire manipulation of the filter was performed. The reports and angiograms from these patients were reviewed with respect to the circumstances surrounding filter placement and methods to achieve more symmetric opening. RESULTS: Transcatheter manipulation of asymmetrically opened filters was performed in 15 of 166 cases (9%). In 12 of these patients, acceptable and uneventful opening of the filter was achieved with a guide wire, pigtail catheter, or occlusion balloon catheter. In one case manipulation only partly improved orientation of the limbs, while in another case successful manipulation was complicated by distal migration. In the final case, the asymmetric filter covered only part of the lumen of the vena cava despite manipulations and a second filter was placed for optimal caval interruption. No specific cause for incomplete expansion was identified in any case. CONCLUSION: Marked asymmetry in opening of the modified hook titanium Greenfield filter that warrants manipulation occurs infrequently, but recognition and proper management may be important to ensure optimal caval interruption.

Catheterization, Central Venous↗
PubMedDate not supplied

Haemophilus influenzae type b disease after rifampin prophylaxis in a day care center: possible reasons for its failure.

Five infants enrolled in a day care center (DCC) developed invasive disease due to Haemophilus influenzae type b during a 25-week period. The isolates from four patients had identical outer membrane proteins and were biotype 1. Although rifampin prophylaxis was recommended on two different occasions, retrospective surveys demonstrated that 39 and 60%, respectively, of infants failed to receive the agent for various reasons. Pharyngeal cultures were obtained from infants, their families and DCC staff after prophylaxis was given the second time. Forty-seven % of DCC infants had positive cultures, and 59% of their households had at least one carrier of the invasive strain. Rifampin prophylaxis administered a third time to infants and members of their households was unsuccessful in eradicating the invasive Haemophilus influenzae type b strain from DCC infants. The possible reasons for failure of rifampin in this DCC outbreak included incomplete understanding by physicians and health department officials of the factors affecting a DCC outbreak of Haemophilus influenzae type b disease and failure properly to implement rifampin prophylaxis to all contacts and the index cases.

Child Day Care Centers↗