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Biomedical subjects

B S Rasmussen

Publications and source records attributed to B S Rasmussen.

11 recordsLinked to original sources

Long-term follow-up of patients with hydronephrosis treated by Anderson-Hynes pyeloplasty.

A series of 21 patients with hydronephrosis (mean age 37 years) underwent an Anderson-Hynes pyeloplasty; a nephrostomy catheter was not used routinely. One patient developed urinary leakage post-operatively but this ceased following insertion of a ureteric catheter. Assessment was carried out after a mean observation time of 85 months. Clinical examination, laboratory investigations, urography and renography were performed pre-operatively and at follow-up. There was no evidence of stones or stenosis in the pelvis. Patients operated upon before the age of 30 years showed improved renal function. All patients had symptoms pre-operatively but only one had symptoms post-operatively. It was concluded that the results of surgical intervention in hydronephrosis are excellent, especially in patients aged less than 30 years.

Adolescent

Postspinal headache in young and elderly patients. Two randomised, double-blind studies that compare 20- and 25-gauge needles.

In two randomised, double-blind studies of elderly patients with a mean age of 68.9 (range 21-88) years and young patients, mean age 29.4 (range 20-40) years, the effect of needle size on the incidence of postspinal headache was compared. The two needle groups, 20- and 25-gauge, were comparable in both studies with regard to number, sex, age and type of surgery. The incidence of postspinal headache in young patients was 27.6% when a 20-gauge needle was used and 12.6% with a 25-gauge needle. There was no significant difference in either the incidence of headache in the elderly patients (10.8% and 7.8%, respectively) or between the sexes. It is concluded that it does not matter if a 20- or a 25-gauge needle is used for spinal analgesia in elderly patients with regard to postspinal headache, but if spinal analgesia is indicated in young patients a fine needle is preferred.

Adult

Impaired pulmonary and cardiac function after maximal exercise.

The cardiopulmonary response to maximal rowing exercise of short duration was studied in six healthy well-trained oarsmen. The lung diffusing capacity for carbon monoxide was significantly decreased below the pre-exercise value for 2.5 days post-exercise (P less than 0.05). Residual volume (RV) showed a significantly increased value at 30 min of recovery (P less than 0.01) with no change in total lung capacity. There was no significant change in transthoracic electrical impedance following exercise but a decrease may have been masked by the increased RV. The changes in the pulmonary parameters may reflect the occurrence of a transient interstitial lung oedema. Exercise-induced bronchoconstriction may be a part of the cardiopulmonary response as peak expiratory flow rate (PEFR) was significantly reduced at 30 min of recovery. The reason for the increase in pulmonary extravascular water volume may be a marked distension of the lung capillaries due to increased blood volume in the lungs and as a consequence increased vascular permeability. The changes may also be caused by impaired myocardial contractility indicated by a split impedance dZ/dt waveform, not previously described in healthy persons, which occurred in all six subjects immediately following exercise.

Adolescent

Decrease in pulmonary diffusion capacity after maximal exercise.

Oppression of the chest, cough and orthopnea are well known to occur in some athletes after competitions, maybe reflecting an increase in lung water. In order to indicate if lung water increases after maximal exercise we measured pulmonary diffusion capacity before and 2.1 h after a short maximal arm exercise bout in 11 canoeists and showed a decrease of 6.7%. The result may be explained by a calculated 17% increase in alveolar interstitial volume.

Adolescent

Intrapleural administration of 0.5% plain bupivacaine compared to 0.5% epinephrine: a hemodynamic and ventilatory study.

The ventilatory and hemodynamic effects of 20 ml 0.5% intrapleural bupivacaine with and without 5 micrograms/ml epinephrine were studied. Ten patients scheduled for intrapleural block in the treatment of chronic visceral pain had a left-sided intrapleural catheter inserted. In a double-blind, crossover design they received 20 ml 0.5% bupivacaine with and without 5 micrograms/ml epinephrine. Forced vital capacity, vital capacity, and forced expiratory volume in one second were measured before and 30 minutes after the injection. Mean blood pressure, heart rate, and cardiac output were recorded before the injection and at five-minute intervals for 30 minutes. Vital capacity, forced vital capacity, and forced expiratory volume in one second were unchanged in both groups. There were no differences in any of the pulmonary function tests between the groups. When data from both groups are pooled, vital capacity shows a decrease of 7% (p less than 0.05). No changes in heart rate or mean blood pressure were seen in either group. Bupivacaine without epinephrine did not affect the cardiac output, whereas bupivacaine with epinephrine resulted in a rise in cardiac output of 15% at 15 and 20 minutes after the injection. We did not find any major effects of intrapleural injection of 20 ml 0.5% bupivacaine with and without 5 micrograms/ml epinephrine on ventilatory capacity or cardiovascular function in patients treated for chronic visceral pain.

Adult