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Biomedical subjects

B S Sengupta

Publications and source records attributed to B S Sengupta.

At least 19 recordsLinked to original sources
PubMed1989

Genital herpes simplex virus infections: laboratory confirmation in diverse patient groups.

The laboratory diagnosis of genital herpes simplex virus (HSV) infections in various patient groups with diverse clinical manifestations including asymptomatic pregnant women with history of genital herpes and in a high prevalence group consisting of male patients with recurring genital ulcerations is described. HSV was detected by conventional cell culture and also by a CPE-enhancement technique using human embryonic lung fibroblasts (MRC-5) and Vero cells with subsequent typing of isolate by HSV type-specific monoclonal antibodies. A definite improvement in HSV diagnosis was noted by the use of the CPE-enhancement technique with the reduction of turn-around time to 24 h at which 61.1% and 50% isolation rates were detected in MRC-5 cells in comparison to 38.9% and 16.6% by conventional cell culture in the high prevalence patient population and asymptomatic pregnant women, respectively. Delayed development of CPE and reduced isolation rates were detected using Vero cells. Follow-up sampling of subsequent episodes of genital ulcerations in those with history of recurrence but an initial negative cell culture result, increased the isolation rate substantially and enabled the confirmation of diagnosis of genital HSV infection.

Cells, Cultured↗
PubMed1989

Enzyme immunoassay in the diagnosis of Chlamydia trachomatis infections in diverse patient groups.

An enzyme immunoassay (EIA) in parallel with cell culture was used to investigate the extent of infections due to Chlamydia trachomatis. EIA reactive confirmed in cell culture was taken as positive. C. trachomatis was found in 6 (26.0%) of 23 men with symptomatic non-gonococcal urethritis (NGU), ten (17.2%) of 58 symptom-free males and in three of 4 with postgonococcal urethritis. Among 106 asymptomatic pregnant women studied the incidence of C. trachomatis was 8.5% while a higher incidence (16.7%) was found in those with symptoms. C. trachomatis positivity in asymptomatic and symptomatic post-natal screening were 11.4% and 7.7%. Of 43 symptomatic non-pregnant females investigated, 7 (16.3%) were found to be positive for C. trachomatis. Of 3 women with PID, 2 (66.7%) harboured C. trachomatis in their cervix while in another 29 infertile women, C. trachomatis was positive in 3 (8.1%). Contraceptives appeared to have an effect on the chlamydial positivity. Comparative testing of EIA with the standard cell culture method in this study indicate EIA as a suitable alternative for the definitive diagnosis of chlamydial infection in high prevalence settings and with caution in low prevalence settings.

Antigens, Bacterial↗
PubMed1988

Vaginal birth after cesarean section: management debate.

Obstetric performance of 1847 women with previous cesarean section (CS) during the years 1983 and 1984 were studied. Vaginal birth after cesarean section (VBAC) was attempted in 94% of females with one previous CS, 4% in those with two previous CS, and one among the 70 patients with three or more previous CS. VBAC was achieved in 51% of those with one previous CS. It was successful in 60% of parturients with CS for non-recurrent causes, 36% of CS for cephalopelvic disproportion (CPD) and in 64% of those with a prior vaginal delivery. Uterine scar dehiscence was found in 0.9% of all patients with a previous CS. A failed attempt with Ventouse to achieve VBAC caused maximum maternal and perinatal morbidity.

Adolescent↗
PubMed1988

Epidemiologic study of gestational trophoblastic diseases in Saudi Arabia.

The role of cultural and socioeconomic diversities (that is, marriage, conceptions at the extremes of reproductive life, consanguinity, economic affluence and such) were analyzed for significance in the epidemiologic study of gestational trophoblastic disease (GTD) in Saudi Arabia. For the study period, the incidence of hydatidiform mole remained unchanged at a mean of one in 448 pregnancies and one in 6,130 for its malignant counterpart. In the instance of molar pregnancies, the youngest (less than 20 years of age) and the oldest (more than 40 years of age) had significantly higher than expected incidence; in contrast, in malignant GTD, the trend was for a higher than expected frequency for the older age group only (more than 40 years of age). Consanguinity showed no significant epidemiologic role.

ABO Blood-Group System↗
PubMed1987

Trend in breech delivery in Saudi Arabia.

An analysis of 2,168 consecutive singleton breech deliveries showed significant improvement in neonatal mortality and morbidity rates for babies delivered by Caesarean section (CS) compared with vaginal delivery (p less than 0.001). The CS rate was 19%. The uncorrected perinatal mortality (PNM) rate was 90.4/1,000 which was 2.5 times higher than the overall hospital PNM rate. In the vaginal delivery group the neonatal death (NND) rate of 206/1,000 among low birth-weight infants (less than 2,500 g) was significantly higher than that of 18/1,000 among babies of greater than 2,500 g (p greater than 0.001). There was no significant difference in the NND rate between these 2 birth-weight groups delivered by CS (p greater than 0.3). Social conservatism, large family size and limited neonatal care facilities were deterrents to an increase in the Caesarean section rate.

Adolescent↗
PubMed1987

Routine screening of gynaecological and obstetric patients for Chlamydia trachomatis.

Chlamydia trachomatis infection of the cervix uteri was diagnosed in 9% of 221 gynaecological and obstetric patients. Infection occurred more commonly among obstetric (12.6%) than gynaecological patients (5.5%). In obstetric patients chlamydial infection was commoner in those complaining of excessive vaginal discharge or spontaneous premature rupture of the membranes. Chlamydial infection in gynaecological patients occurred in those with previous pelvic infection, menstrual disorders or excessive vaginal discharge. No cases of chlamydial infection were detected among intrauterine device users. The enzyme immunoassay we used is an easy and relatively quick method of diagnosis for genital chlamydial infection.

Cervix Uteri↗
PubMed1986

Intracervical application of prostaglandin E2 tablets for elective induction of labor in grand multiparae: a prospective controlled study.

In a prospective and controlled study labor was induced electively in 150 grand multiparae (GM) between 38 and 42 wk gestation by intracervical application of PGE2 tablets (induction group). Another 150 GM who went into labor spontaneously served as controls for comparison of labor characteristics and outcome (control group). In the induction group labor was successfully induced in 147 GM (98.0%), of whom 142 (96.5%) delivered vaginally. The mean duration of the active phase of labor was 2.1 +/- 0.79 h in GM who delivered on the first day of induction and 2.8 +/- 0.47 h in women who delivered on the second day, as compared to 4.7 +/- 2.2 h in the controls. Similarly, the mean duration of the second and third stage was longer in the controls. Operative deliveries were 2--3-times more frequent among controls, as were complications in the second and third stages. The group profiles of the I.U.P. charts indicating rise time, fall time, amplitude and Montevideo units at different stages of cervical dilatation showed significant differences at 4-5 cm dilatation only between the two groups of women. It is concluded that elective induction in GM between 38 and 42 wk is safe for mother and fetus.

Adult↗
PubMed1986

The pattern of female genital tuberculosis in Riyadh, Saudi Arabia.

An analysis of 40 patients with genital tuberculosis in the Maternity and Children's Hospital, Riyadh, Saudi Arabia, showed that female genital tuberculosis occurred in 0.45% of all gynaecological admissions, a much higher rate than those reported from Western countries with a similar economic background. These 40 women accounted for 4.2% of a total of 945 infertile women studied during the same period, and where infertility was due to a tubal factor, 1 in 7 was afflicted with tuberculosis. Most patients were young nulliparae and in 13 the disease was florid. Complete cure was achieved with chemotherapy in 77% of the patients, but tubal patency was restored in only five of 35 patients followed up (14%). There were only two tubal pregnancies and no intrauterine pregnancy. Genital tuberculosis should be considered as a possible cause of infertility and excluded before embarking upon tubal surgery or ovulation-induction therapy.

Adult↗
PubMed1983

Maternal mortality in Riyadh, Saudi Arabia.

The maternal mortality in the Maternity and Children Hospital, Riyadh, during the years 1978-1980 was 52 per 100 000 births, when the total births were 55 428. This is higher than the rate reported from the hospitals in developed countries but lower than rates reported by the university hospitals of developing countries such as India, Thailand and Nigeria. Haemorrhage, associated disease, pulmonary embolism and infection, in that order, were the main causes of maternal deaths. The main avoidable factor was failure by the patient to seek the medical care. Much could be done in reducing deaths due to haemorrhage by improving blood transfusion facilities in the peripheral hospitals. Adequate health education, especially of rural women and their midwives, is a crucial factor in improving the maternal death rate for the country as a whole.

Abortion, Spontaneous↗
PubMed1981

Carcinoma of the vulva in Jamaican women.

Clinical and pathological analysis of vulvar carcinoma in 119 Jamaican women, treated at the University Hospital of the West Indies, over the past 18 years stresses that the tumor was more frequently seen in women under the age of 50 - contrary to the experience of authors from the Western metropolitan countries. The natural history of the tumor showed that in 51% of cases, vulvar carcinoma co-existed or followed previous chronic vulvar granulomatous diseases and showed a rapid tumor progression in these post-granulomatous cases. Features of other epidemiological and clinical important are discussed. Special reference has been made concerning the problem of applying FIGO staging of vulvar carcinoma.

Adolescent↗
PubMed1978

Myomectomy in infertile Jamaican women.

One hundred nineteen Jamaican women who underwent myomectomy from 1964 to 1969 were followed up for 5 to 9 years. Infertility was the most common presenting complaint. Preoperative hysterosalpingograms were performed on 61 patients and were abnormal for the majority of these patients. Surgery revealed submucous fibroids in 41 patients and pelvic inflammatory disease in 51 patients. The pregnancy rate following myomectomy was 18.5%, but successful outcomes occurred in only 9.2% of the cases. Pregnancy was unsuccessful for all patients who underwent both myomectomy and tuboplasty. Twenty-three patients had a recurrence of myoma, and 13 of these underwent subsequent hysterectomy.

Adult↗
PubMed1977

Choriocarcinoma in Jamaica.

Fifty-two cases of choriocarcinoma were recorded in the Jamaica Cancer Registry for the parishes of Kingston and St. Andrew, giving an incidence of 1:7,384 live births. This is intermediate between figures reported for Western metropolitan populations and for Far Eastern countries. Clinicopathological studies on 26 cases treated at the University Hospital in Jamaica revealed that 65% followed either normal pregnancy or abortion. Choriocarcinoma following a normal pregnancy or occurring without a previous history of pregnancy carried a poorer prognosis than those with a preceding hydatidiform mole. Many patients had primary neurological manifestations. The overall prognosis was poor due to late presentation with disseminated metastases. Of the 26 patients, 15 died of the disease within two years and only six appeared for a six-year follow-up.

Adolescent↗