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Biomedical subjects

B S Zaporozhchenko

Publications and source records attributed to B S Zaporozhchenko.

17 recordsLinked to original sources
PubMed2005

[Functional state of the liver in patients with an acute destructive pancreatitis in the early postoperative period].

The efficacy of conventional complex treatment and such, including pentoxyphylline, lipoic acid and the aminoacids mixture, was studied in early postoperative period in 64 patients with an acute destructive pancreatitis. The highest levels of general and direct bilirubins, the aminotransferases activity were established initially in those patients, in whom the polyorgan insufficiency syndrome (PIS) occurred subsequently. More significant normalization of the indexes under the influence of treatment was observed in patients without PIS, in patients with PIS the pharmacological resistance was registered. More favourable course of postoperative period was observed in patients, in whom pentoxyphylline, lipoic acid and the aminoacids mixture were included in complex of treatment.

Adult↗
PubMed2003

[Changes of cytokine levels in the serum in patients with acute pancreatitis as an early symptom for diagnosis].

Changes of concentration of proinflammatory cytokines--tumor necrosis factor (TNF), interleukin-1, growth transforming factor, granulocyte--macrophage colony stimulating factor in the blood serum of patients with probable diagnosis of an acute pancreatitis (AP) were examined. Seven days before the disease occurrence the TNF concentration rise was observed, what proved, by the authors opinion, its significance as an early diagnostic criterion for AP. Other diagnostic methods did not prove their information value in determination of the disease occurrence during the 7 day premorbid period.

Acute Disease↗
PubMed2000

[Changes in free amino acid plasma levels in patients with acute pancreatitis and their correction with early parenteral feeding].

The lowering of general pool of free amino acids in the blood plasma by 54.9%, comparing with their content in practically healthy persons, was observed in 17 patients with an acute pancreatitis. And by this the content of the majority of amino acids was lowered, excluding glutamate, phenylalanine and methionine, the level of which had raised. Under the conventional treatment influence the amino acids concentration had enhanced and constituted 60% from such in the control group, while in application of parenteral nutrition (intravenous infusion of the infezol 40 solution)--85.9%. By that the formation of the polyorganic insufficiency syndrome was not noted and the level of each amino acid had normalized.

Acute Disease↗
PubMed1998

[The function of the thiol-disulfide and ascorbate systems in patients operated on for acute pancreatitis after the use of low-intensity infrared laser radiation and pentoxifylline].

In patients with an acute destructive pancreatitis the lowering of sulphhydride (SH) groups in proteinic and nonproteinic fraction of the blood plasma, the reduction of the ascorbic acid level and increase of its oxidized forms concentration was noted. After the operation the disordered indexes have restored, moreover, and after the programmed relaparotomy conduction--as after a single operative intervention. Acceleration of the disordered indexes restoration was promoted by application of pentoxifylline and low-intensity laser irradiation as well.

Acute Disease↗
PubMed1998

[Changes in lipid metabolism and indicators of immunological reactivity in programmed relaparotomy in acute pancreatitis].

The increase of low-density lipoproteids contents, high-density lipoproteids level lowering, reduction of the lymphocytes blast transformation reaction indexes, IgG level lowering, the rosette formation reduction were noted in patients with an acute pancreatitis. While the programmed relaparotomy application of the lipid-aliphatic metabolism restoration was noted, and the immunological reactivity as well with the dynamics higher than after single operative intervention conduction.

Acute Disease↗
PubMed1998

[Changes in blood enzyme activity and tumor necrosis factor level in the treatment of experimental pancreatitis with pentoxifylline].

It was established in an acute experiment on rats of Wistar line while an acute pancreatitis simulation using the pancreatic tissue freezing that the level of a tumor necrosis factor (TNF) in a blood serum was maximal in 4 hours from the cold action onset, the activity of amylase and trypsin was heightened and trypsin activity inhibitor (TAI) had lowered. Intraperitoneal application of pentoxifylline in 100 mg/kg dose twice daily have promoted the significant lowering of TNF contents, the amylase and trypsin activity as well, and the TAI concentration increase.

Acute Disease↗
PubMed1998

[Surgical techniques in complicated chronic pancreatitis].

The experience of surgical treatment of 77 patients with complicated chronic pancreatitis was summarized. Among the operations conducted were: internal drainage, including cystogastrostomy-in 24, cystoduodenostomy-in 9, cystojejunostomy-in 12, fistulojejunostomy-in 2, longitudinal pancreatojejunostomy-in 17, and pancreatic gland resection (proximal-in 2 and distal one-11). After the operation 4 (5.1%) patients died.

Chronic Disease↗
PubMed1997

[Remote dynamic radiation thermography in the diagnosis of acute inflammatory diseases of the pancreatico-hepato-biliary tract].

The method of the remote radiation dynamic thermometry was elaborated usid information--diagnostic complex "Thermodyn". Among the examined patients there were 55 with cholecystitis, 20--with pancreatitis, 15--with cholecystopancreatitis, 65--healthy people. In chronic calculous cholecystitis in the remission stage the thermal stream density deviation from the mean for the abdominal cavity constituted 2.3%, in an acute stage--5.8%, in an acute cholecystitis--9.1%. In the patients with edematous form of acute pancreatitis the thermal stream density deviation in the pancreas projection was 10.2% of the median for the abdominal cavity, in pancreonecrosis--18.4%. Cholecystopancreatitis is characterized by the thermal stream density increase in epigastric region, both subcostal regions and in the pancreas projection.

Acute Disease↗
PubMed1997

[Analysis of the surgical treatment results in patients with acute pancreatitis].

The results of treatment of 248 patients with an acute pancreatitis (AP) are analyzed. Conservative therapy was effective in 178 of them. Mortality was 0.3%. Surgical intervention was done in 64 patients, including 25 with AP, of them 2 (8%) have died; 27--with destructive AP, after cholecystectomy, drainage of bursa omentalis and abdominal cavity 15 (55.5%) died. Pancreatic resection, necrotomy, programmed relaparotomy with permanent necrotomy of pancreas and retroperitoneal cellular tissue were conducted in 17 patients, 3 (17.6%) died.

Acute Disease↗