PubMed Health⌕ Search

Biomedical subjects

B Sack

Publications and source records attributed to B Sack.

6 recordsLinked to original sources
PubMed1990

[A critical analysis of the SNA, SNB and ANB angles in assessing orthodontic treatments].

The purpose of this longitudinal cephalometric study was to evaluate the influence of growth changes at nasion (N) on the position of the reference line NSL and consequently on the measurements of the angles SNA, SNB and ANB. Lateral head films from 46 orthodontically treated patients were evaluated over an average period of 3.7 years. The NSL reference line was defined with respect to growth changes at the N-point: A: no consideration of growth; B: consideration of growth in the sagittal plane; C: consideration of growth in the sagittal and vertical planes. The results showed that growth changes at nasion had a decisive influence on the position of the reference line NSL and thus also on the angles SNA, SNB and ANB. In order to avoid misinterpretations in the evaluation of orthodontic treatment results the growth changes at nasion must be taken into consideration.

Cephalometry↗
PubMed1990

Laboratory observations on Plesiomonas shigelloides strains isolated from children with diarrhea in Peru.

Eleven strains of Plesiomonas shigelloides isolated from 10 Peruvian children with diarrhea were examined. All the strains were resistant to two or more antibiotics, most commonly ampicillin, gentamicin, erythromycin, kanamycin, and streptomycin. The strains were all negative in the Sereny and cell culture assays used to test for enteroinvasiveness. One strain showed cytotoxic activity on Vero cells. The strains showed no antigenic relationship with Shigella organisms. Both bioassays and enzyme-linked immunosorbent assays used for detection of Escherichia coli enterotoxins were negative. Nucleic acid probes for such toxins likewise gave negative results. The strains all possessed a large (approximately 200-megadalton) plasmid in addition to one or more other plasmids. Several different plasmid profiles were observed among these 11 P. shigelloides strains, indicating that the isolates were not acquired from a common source or from a single bacterial clone.

Child↗
PubMed1988

Anticentromere antibodies--clinical correlates.

We tested 11,594 consecutive sera for antinuclear antibodies and 1,502 were found to be positive; 68 patients (72 sera) had anticentromere antibodies. A retrospective analysis of the clinical characteristics and diagnoses of patients found to have anticentromere antibodies were correlated and showed a diverse array of findings. The association of anticentromere antibodies and the CREST variant of scleroderma may be less specific than originally thought when used as a screening test in an unselected population with rheumatic disease. Anticentromere antibody was present in patients with drug induced lupus, a finding not previously reported.

Adult↗
PubMed1985

The clinical features of elderly-onset rheumatoid arthritis. A comparison with younger-onset disease of similar duration.

Patients with elderly-onset rheumatoid arthritis (EORA) may represent a clinical subset of individuals who differ prognostically and therapeutically from patients with younger-onset disease (YORA). In order to test this hypothesis, we reviewed the records of 212 patients with rheumatoid arthritis and grouped them according to age at onset above or below 60 years old. Seventy-eight EORA patients and 134 YORA patients with disease duration of less than or equal to 10 years were used for a comparison of presenting features and disease outcome. Abrupt onset occurred somewhat more frequently in EORA, but was not associated with a significantly different clinical course than was an insidious presentation in this older group. There were no differences between the EORA and YORA groups in terms of mean initial joint score, although the scores for the YORA group had wider variation. An initial clinical presentation resembling polymyalgia rheumatica (PMR) was 4 times as frequent in EORA. Elderly patients were less likely to have subcutaneous nodules or rheumatoid factor at disease onset. At the final examination, the EORA patients had lower joint scores and higher health assessments despite similar courses of treatment. These outcome differences persisted when patients with PMR-like presentations were excluded. Multivariate analyses indicated that joint scores and disease duration made important contributions to a better outcome of EORA, whereas PMR presentation and abrupt onset did not. After an adjustment was made for these 4 features, age at onset was an important contribution to joint score outcome. These results confirm the existence of important differences in onset, clinical features, and prognosis between patients with EORA and those with YORA.

Adrenal Cortex Hormones↗
PubMed1984

Iatrogenic morbidity accompanying suppression of temporal arteritis by adrenal corticosteroids.

The records of 19 patients receiving corticosteroid therapy for temporal arteritis were reviewed. Of 11 patients (58%) who suffered major corticosteroid related complications (group A), four died. Eight patients (group B) remained free of serious corticosteroid related complications. The average daily maintenance prednisone dose was 26.3 mg in group A and 13 mg in group B. Although all disease recrudescenses in both groups were treated by increasing the corticosteroid dose, a slower tapering of the dose to the pre-flare level was observed in group A. These findings emphasize the necessity of keeping the maintenance corticosteroid dose in patients with temporal arteritis at the lowest level consistent with suppression of disease activity.

Adrenal Cortex Hormones↗