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Biomedical subjects

B Sanner

Publications and source records attributed to B Sanner.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Complications of nasal CPAP therapy. Consequences for general practice].

BACKGROUND: The prevalence of the obstructive sleep apnea syndrome is about 5% in the entire population. The amount of treatment-indications grows for this particular sleep-related breathing disorder due to the increasing usage of diagnostic screening tests. In most cases, the positive-pressure ventilation, PPV (nCPAP, nBiPAP) is considered as a highly effective form of treatment, in comparison to other treating methods. The residential polysomnographic supervised adjustment of the treatment is optimally applied to most of the patients. Due to the increasing number of the treated patients, the reports about the appearance of short-termed side effects during the adjustment of the PPV become more frequent. PATIENTS AND RESULTS: We report on 9 patients who showed complications during the initial stage of treatment. The most common one, during the nCPAP-therapy, was the increase of central apneas. Because of this complication, a rapid optimization of the respiratory pressure or a change to a nBiPAP-therapy was necessary in 5 of the patients. 2 of the patients showed cardiac arrhythmias, some of which were severe. One patient produced a remarkable central hypoventilation during the initial phase of a nCPAP-therapy. The nBiPAP-titration combined with right-heart-catheter monitoring could demonstrate in another patient a possible cardiac decompensation through an increased ventilatory pressure. CONCLUSION: The risk of a positive-pressure ventilation is higher in patients with accompanying cardiac, pulmonary, neuropsychiatric and/or otorhinolaryngologic disorders. Considering the various predisposing factors of the patients we suggest an intensive apparative monitoring as well as stuff-supervision during the introduction to a respiratory treatment. If complications appear, a rapid improvement of the ventilatory pressure or a change to another respiratory treatment is indicated.

Aged↗
PubMed1996

[Coronary heart disease in patients with obstructive sleep apnea].

OBJECTIVE: As patients with severe obstructive sleep apnoea (OSA) have increased cardiovascular morbidity and mortality rates, the prevalence of coronary heart disease (CHD) was investigated in patients with OSA proven by polysomnography (apnoea/hypopnea index > or = 10/h). PATIENTS AND METHODS: In 440 patients (400 men, 40 women; mean age 55.3 [16-80] years) with OSA proven by polysomnography, the possible diagnosis of CHD was assessed by history, physical examination, ECG at rest and on exercise, one- and two-dimensional echocardiography and, where indicated, myocardial scintigraphy and coronary angiography. RESULTS: CHD was demonstrated by angiography in 24.6% (men: 26.4%; women: 7.5%). Adding patients with CHD diagnosed noninvasively, but unconfirmed by angiography, positive correlation was found in 33.2% (men: 34.8%; women: 17.5%). CONCLUSION: There was a high prevalence of CHD in patients with OSA. This underlines the importance of careful cardiac diagnosis in patients with OSA.

Adolescent↗
PubMed1996

Magnetic resonance angiography as a technique for the visualization of hemodialysis shunts.

In order to test the suitability of magnetic resonance angiography for the visualization of Brescia-Cimino hemodialysis shunts, 20 patients (8 women, 12 men, aged 24-69 years) were examined with this technique. The shunt arm was placed in an extremity coil. The time-of-flight method was applied. Examination time was less than 15 min. Arterial digital subtraction angiography (DSA) of the shunt arm was carried out additionally in 8 patients in whom pathological results had been obtained. Surgery was performed on 2 patients. In all cases, the feeding artery, anastomosis, and shunt were clearly visible. The results corresponded exactly to those of DSA and, in the patients who had undergone surgery, also to the situs. The patients stated that the examination technique was not very disturbing. Magnetic resonance angiography in the time-of-flight technique seems to be recommendable for the examination of Brescia-Cimino dialysis shunts. Compared to DSA, it has major advantages: it is noninvasive, and no ionizing radiation or contrast medium are associated with the procedure.

Adult↗
PubMed1996

[Modification of cardiopulmonary performance parameters in patients with obstructive sleep apnea treated with nCPAP therapy].

nCPAP influences cardiopulmonary hemodynamic function in patients with obstructive sleep apnea (OSA). It is known that systolic function of the right and left ventricle, systemic and pulmonary hypertension, arterial blood gases and lung function during the day may improve under this treatment. We prospectively followed 30 patients with severe OSA and determined diastolic left ventricular function (Doppler echocardiography), cardiovascular efficiency (steady state exercise stress testing); and individual assessment of performance (standardized psychometric questionnaire) before, and 2 weeks and 6 months after initiation of nCPAP treatment. The following results could be obtained (first value after 2 weeks, second value after 6 months): Doppler echocardiography: E/A rose by 9.3% (p < 0.05) and another 0.5% (n.s.). E/A integral increased by 13.8% (p < 0.01) and another 3.5% (n.s.). Deceleration period decreased by 22.7% (p < 0.01) and another 3.1% (n.s.). Steady state exercise stress testing: Maximum performance rose by 10% (p < 0.05) and another 17.5% (p < 0.01). Heart rate ratio 100 W/rest dropped by 13.5% (p < 0.001) and another 6.5% (p < 0.01), systolic blood pressure ratio 100 W/rest by 0.8% (n.s.) and another 14.9% (p < 0.001). Diastolic blood pressure ratio 100 W/rest did not change significantly. Questionnaire: Assessment of well-being increased by 44.5% (p < 0.05) and another 16.9% (n.s.). After an initial drop of 0.8% (n.s.), quality of life increased by 14.9% (p < 0.05). Assessment of performance rose by 21.7% (p < 0.05) and another 4.1% (n.s.). nCPAP therapy in patients with OSA improves diastolic function of the left ventricle, cardiovascular performance and individual assessment of performance.

Adult↗
PubMed1996

[Obstructive sleep apnea in patients with coronary heart disease].

Patients with obstructive sleep apnea have an increased cardiovascular morbidity and mortality, those with co-existent coronary artery disease being particularly at risk. The object of our study was to evaluate the prevalence of obstructive sleep apnea in patients with coronary artery disease. 153 patients (117 men, 36 women) with verified coronary artery disease were given a highly sensitive standardized questionnaire. The 59 patients with pathological results were then checked with a 6-channel non-laboratory monitoring system. 22.2% of all patients had a respiratory disturbance index (RDI) above 5/h. and 14.4% above 10/h. 13.3% had a pathological RDI and additionally suffered from excessive daytime sleepiness. Patients with coronary artery disease have a high prevalence of obstructive sleep apnea and should consequently be screened for this sleep-related breathing disorder.

Aged↗
PubMed1995

[Constancy of the nCPAP pressure values in the long-term monitoring of patients with obstructive sleep apnea].

A retrospective study was undertaken to discover how often mask pressures had to be adjusted over time in patients treated for sleep apnoea by continuous positive airway pressure (nCPAP). Data were analysed on 106 such patients (95 men, 11 women; mean age 55.6 [33-74] years). Their body-mass index was 31.5 +/- 5.5 kg/m2, the apnoea hypopnea index before adjustment 7.6 +/- 2.2 mbar. At the first control, after a median of 7.5 months, the pressure had to be adjusted in 55% of patients, by an average of 8.3 +/- 2.4 mbar (P < 0.001). At the second and third follow-ups (after 19.5 and 31.5 months, respectively), no further significant adjustment in mean pressure was necessary, while changes had to be made in 34.0% and 17.9%, respectively. Changes in body weight correlated with changes in pressure level (r = 0.4614 for difference between initial setting and first control; r = 0.6708 for first and second controls; r = 0.7013 for second and third controls). 61% of patients in whom mask pressure had to be altered had symptoms. Of those in whom the pressure had to be increased 82% had symptoms. Only 17% of patients requiring no change had symptoms. These findings indicate that patients on nCPAP must be monitored by polysomnography about 6 months after the initial setting, and further tests should be performed about a year apart. If body weight and feeling of well being are maintained, non-laboratory monitoring should be adequate.

Adult↗
PubMed1995

[Cine-MRT in the functional and morphological diagnosis of the heart after a myocardial infarct/ A comparison with angiocardiography, 2-dimensional echocardiography, intracardiac scintigraphy and enzymatic infarct size estimation].

PURPOSE: The aim of the study was to test the reliability of cine magnetic resonance imaging (cine-MRI) on the infarction heart with its altered geometry. MATERIAL AND METHODS: 61 patients (17 women, 44 men, 36-83 years, 32 with anterior, 29 with posterior wall infarction) received Cine-MRI in the true long and short axis of the heart and two-dimensional echocardiography one and 4 weeks post infarction. Two-level angiocardiography (ACG) and radionuclide ventriculography (RNV) were performed 4 weeks p.i. The size of myocardial infarction was determined enzymatically with the CK integral method. Left ventricular volume indices (EDVI, ESVI, SVI), ejection fraction (EF) and infarction weight (IW) were compared. RESULTS: Excellent correlations existed between cine-MRI in the long and short axis for the volume indices and EF. Between cine-MRI in the short axis and ACG all correlations were excellent as well. They were significantly less satisfactory between cine-MRI and 2DE due to the inhomogeneity of echo quality. Cine-MRI and RNV produced similar EF results (r = 0.884), and a comparison of IW in cine-MRI and CK integral method also showed a good correspondence (r = 0.967). CONCLUSION: Cine-MRI is a reliable method for the morphological and functional examination of post-myocardial infarction.

Adult↗
PubMed1995

Clinical significance of ventricular late potentials in patients with obstructive sleep apnoea.

Patients with obstructive sleep apnoea (OSA) have an increased cardiovascular mortality and probably also an increased incidence of sudden cardiac death. Thus the question arises whether ventricular late potentials can constitute markers for an increased electric vulnerability in these patients. Signal-averaged electrocardiograms were recorded in 64 patients (6 female, 58 male; mean age 53.2 y) with OSA (mean apnoea-hypopnoea index (AHI) 41.7 h-1 +/- 24.3 h-1). Furthermore, a continuous ambulatory electrocardiogram and gated radionuclide ventriculography were performed. Ventricular late potentials were recorded in 5 men out of 64 patients. Two of them had coronary artery disease (1 patient post-myocardial infarction), 2 hypertension, and 1 nocturnal hypertension. No correlation could be traced between left ventricular ejection fraction, severity and extent of ventricular premature beats, or severity of OSA and occurrence of ventricular late potentials. It was noticeable, however, that the patients with ventricular late potentials had severe OSA (mean AHI 50.2/h vs. 40.9/h). Although OSA may lead to structural myocardial changes that could be the basis for re-entrant circuits, ventricular late potentials were found in only 7.8% of these patients. The results of this study demonstrate that at present ventricular late potentials and signal-averaged electrocardiograms do not prove useful as screening methods for risk stratification of patients with OSA.

Journal Article↗
PubMed1995

[Sleep disorders in patients with dialysis-dependent renal failure].

A questionnaire was performed in order to classify the prevalence of sleep disorders in patients with end-stage renal disease treated with hemodialysis. 69 patients (41 male, 28 female) with a median age of 57 years completed the questionnaire. 67% of these patients complained of sleep disorders. 31 patients (45%) had evidence of periodic leg movement syndrome, 22 patients (32%) of restless legs syndrome. 29 patients (42%) had difficulties in falling asleep, 27 patients (39%) in maintaining sleep and 17 (25%) experienced both. Snoring was found in 25 patients (36%), 13 patients (19%) seemed to have sleep apnea. These data show an increased prevalence of sleep disorders in patients with end-stage renal disease on hemodialysis treatment. We conclude that these patients should consequently be asked for sleep disorders, as a specific diagnostic and therapeutic regime could improve quality of life and life expectancy. Especially sleep apnea is a disease that has a high prevalence in this patient group and which can be treated successfully.

Adult↗
PubMed1995

[Structural cardiac changes in patients with obstructive sleep apnea].

Important pathophysiological mechanisms in obstructive sleep apnea at night are increasing pleural pressure swings, hypoxia and hypercapnia, as well as central nervous arousals with consecutive fragmentation of regular sleep structure. They influence the cardiovascular system, at first only at night and at a later stage also during the day. This might result in cardiac structural changes: dilation and hypertrophy of the right ventricle, hypertrophy of the left ventricle, (especially of the muscular ventricular septum), dilation of right and left atrium. It is suggested that these cardiac structural changes are characteristic for obstructive sleep apnea and therefore define the "sleep apnea heart".

Cardiomegaly↗
PubMed1995

[Effects of nCPAP therapy on the blood picture in patients with obstructive sleep apnea].

In some patients with obstructive sleep apnea, changes in red blood cell count resembling polycythemia can be observed. If these changes result from the sleep-related breathing disorder, its adequate treatment should in turn induce a decrease of, for instance, hemoglobin concentration. We therefore set out by examining retrospectively the development of hemoglobin concentration under nCPAP in 130 patients with polysomnographically verified obstructive sleep apnea, comparing the values before treatment and after a mean of 12.0 months. During this period, hemoglobin mass concentration dropped from a mean of 153 +/- 13 g/Ls to 148 +/- 11 g/Ls (p < 0.001). Afterwards we prospectively examined in 50 patients the changes in complete blood cell count before and immediately after initiation of nCPAP treatment. It turned out that hemoglobin mass concentration dropped from a mean of 154 +/- 14 g/Ls to 148 +/- 14 g/Ls (p < 0.001), the erythrocyte count from 5.02 +/- 0.42/pl to 4.79 +/- 0.51/pl (p < 0.001), and hematocrit from 45.4 +/- 3.1% to 43.1 +/- 4.3% (p < 0.001) after only one night; no more significant change occurred after that. Increased hemoglobin mass concentrations, erythrocyte counts and hematocrit values can be the result of obstructive sleep apnea. Treatment of this sleep disorder with nCPAP will induce a quick and significant decrease of hemoglobin mass concentration, erythrocyte count, and hematocrit, independent of the initial values. This phenomenon points to the fact that changes in blood cell counts are not caused by a disturbance of erythropoesis but rather by alterations in volume regulation.

Adult↗
PubMed1995

[Right ventricular function in patients with obstructive sleep apnea].

Obstructive sleep apnea often affects the cardiovascular system. So far, only few data are available on its influence on the function of the right ventricle that can be evaluated by gated radionuclide ventriculography. This technique was performed on 68 patients with polysomnographically verified obstructive sleep apnea. 27.9% of the patients showed an impairment of right ventricular function. There was no correlation between right ventricular function and degree of obstructive sleep apnea or pulmonary artery pressures--as evaluated by right heart catheterization. Gated radionuclide ventriculography thus seems to be suitable for early detection of pathological effects of obstructive sleep apnea on the function of the right ventricle.

Adult↗
PubMed1991

[Eosinophilic gastroenteritis as an allergic reaction to a trimethoprim-sulfonamide preparation].

One week after treatment of a urinary infection with co-trimoxazole (twice daily 160 mg trimethoprim and 800 mg sulphamethoxazole) a 21-year-old man suddenly started to vomit, accompanied by watery diarrhoea, abdominal swelling and weight loss of 5 kg. Plain X-ray film of the abdomen while standing showed multiple fluid levels in the small intestine of the upper and lower abdomen. Serum IgE concentration was elevated to 325 U/ml. There was a leukocytosis of 25,800/microliters, with a differential count of 45% eosinophils. Protein-rich ascites contained numerous eosinophils and the mucosa of the terminal ileus and the duodenum was infiltrated with eosinophils, findings which indicated eosinophilic gastroenteritis. All symptoms regressed completely within 10 days of stopping co-trimoxazole and administering prednisolone (50 mg/day). Four years later a similar episode of eosinophilic gastroenteritis developed after the patient had taken trimethoprim with a sulphonamide (once daily 180 mg trimethoprim and 820 mg sulphadiazine). It again quickly responded to short-term administration of glucocorticoids.

Adult↗
PubMed1990

[Frequency of pathological changes of the upper gastrointestinal tract in patients awaiting heart surgery].

While waiting for open heart surgery, in 153 patients (104 male, 49 female, 22-76 years of age) without gastrointestinal symptoms and/or history esophago-gastro-duodenoscopy was performed. 124 patients suffered from coronary heart disease, 29 from valvular defect, aneurysm of the sinus of Valsalva or tumor of the heart. In 47.1% endoscopy revealed serious abnormal findings: in 16.3% gastric ulcer, in 20.9% erosive gastritis, duodenal ulcer and erosive duodenitis in 5.2%, respectively, 1 case of gastric carcinoma, 2 of large polyps and 3 of reflux esophagitis of higher degree (totally 3.9%). In patients with coronary artery disease, the relation of erosive and ulcerous gastric lesions as compared with those of duodenal origin was 4:1, in patients with other cardiac diseases it was 2:1, respectively (p less than 0.001). Compared with a normal population, the incidence of pathological gastric findings was 54-fold higher in our patients, and 1.7-fold concerning duodenal lesions, respectively (p less than 0.001). 51 patients on acetylsalicylic acid (160 mg/die) showed pathologic findings in 41.2%, and 96 patients without ulcer-inducing therapy in 51%. Thus, low-dose Aspirin does not seem to have serious gastric side effects. The results of the study stress the necessity of routinely performed endoscopy of the upper gastrointestinal tract in patients awaiting open heart surgery. This will lead to a lower incidence of serious gastrointestinal complications postoperatively which are known to have a high mortality.

Adult↗