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B Schade

Publications and source records attributed to B Schade.

7 recordsLinked to original sources
PubMed1991

Evidence that the osmotically fragile yeast S. cerevisiae VY1160 is an actin mutant.

The phenotype of the osmotically dependent S. cerevisiae mutant VY1160 is caused by a single chromosomal mutation, termed srb, with pleiotropic effect. Compared with cells of the parental strain S288C, it was shown that the size and surface structure of the mutant cells are changed. The latter are sensitive to elevated cultivation temperatures as well as to hypotonic pressure and mechanical stress. In these cases, specific plasma membrane alteration were revealed by freeze-fracture electron microscopy. The total actin content is only 88% (21.4 micrograms actin/mg protein) of that of S288C cells. Remarkably, the mutant cells contain only 2.2 micrograms F-actin/mg protein, whereas the S288C cells have 10.3 micrograms F-actin/mg protein. Moreover, the level of reduced glutathione is found to be higher in the mutant cells (23.4 nmole/10(10) cells) than in the parental cells (15.2 nmole/10(10) cells). These results implicate that the srb mutation is localized in the actin gene.

Actins↗
PubMed1988

In vivo effects of nifedipine and BAY 1 8201 on ceruletide induced gallbladder contraction.

Studies in animals suggest that calcium channel blockers may influence gallbladder contraction. In order to study possible actions in man we examined by ultrasonography the effects of two dihydropyridine derivatives, i.e. nifedipine (20 mg p. o.) and BAY 1 8201 (100 mg p.o.) on ceruletide induced human gallbladder contraction in 9 healthy male volunteers in a randomized, double-blind, three fold crossover study (latin square design). Blood samples for the measurement of plasma drug concentrations were drawn before and at regular intervals up to 8 h after drug ingestion. Ceruletide decreased gallbladder volumes by 52.1 +/- 8.2% (mean +/- 1 SEM) after nifedipine, 53.1 +/- 8.1% after BAY 1 8201 and by 59.3 +/- 10.1% after placebo (NS). Peak plasma concentrations of 53.7 x/: 2.3 ng/ml (geometric mean x/: geometric standard deviation) and of 35.5 x/: 1.5 ng/ml were reached after oral application of nifedipine and BAY 1 8201, respectively. We conclude that human gallbladder contraction in response to ceruletide is not markedly influenced by dihydropyridine derivates in the dosages used in this study. The results reported here stress the importance of calcium released from intracellular stores for the contractility of smooth muscle in the human gallbladder.

Adult↗
PubMed1976

Biographical situation of scoliotic children and their relationship to the social environment(author's transl).

Studies were conducted to determine whenther or not scoliosis in childhood affects the behavior and experience of the affected children. Two groups of scoliotic and nonscoliotic children were examined with selected psychological tests. No differences could be found in regard to neuroticism, extraversion, manifest fear or the children's self-image. Differences were found in regard to the social environment which scoliotic children experienced as more demanding and supportive. As a result they were more concerned with achievement in a performance situation and more confident of success. The type and extent of the psychological effects of scoliosis is determined by the position accorded to the children by the social environment. Negative consequences can best be dealt with by educating the parents.

Adolescent↗
PubMed1975

[The personality of children with weak posture].

An attempt is made on two groups of children with weak posture and of normal children aged 8 to 10 years to demonstrate a statistical link between fibrous tissue-weakness and certain psychological characteristics. In tests and observations of experiences and behavior of children one finds: Compared with the controls the children showing symptoms suffer psychosomatic changes. The cause is held to be not just increased psychomotor clumsiness, but their behavior pattern is essentially due to psychological pressure of their environment (parents, school, friends etc). This leads to: reduction self-confidence, increased experience of failure, hypercompensatory view of the self with strong criticism of others and again physical dysfunction. To offer treatment is not enough. We have to demand a spread of information, cooperative efforts of teachers , school-physicians and parents and education by team-work.

Activities of Daily Living↗
PubMedDate not supplied

[Aging in developing countries].

After presenting informations about the general life conditions in the less developed regions, the author concentrates on the term "syndrome of poverty", which have a great impact on the life conditions and the status of the elderly. Demographic data concerning the world population of all ages and the aged population in the more developed and the less developed regions follow.

Aged↗