PubMed Health⌕ Search

Biomedical subjects

B Schlesinger

Publications and source records attributed to B Schlesinger.

15 recordsLinked to original sources
PubMed1996

Lone-parent families in cross-cultural perspectives: ethnic and immigration issues.

"One-parent families represent about 10-20 percent of all families in Europe, North America, New Zealand and Australia. About 90 percent are headed by women, who have become heads of households mainly due to divorce, separation, and never-married status. The presentation will review existing research and data related to cross-cultural one-parent families. The topics covered include routes to lone parenthood, characteristics common among female-headed families, positive and negative aspects of this type of family, up-to-date statistics, and a discussion of children living in one-parent families. Implications for immigration and ethnicity issues will be included...as well as research implications and intervention strategies for the one-parent family."

Americas↗
PubMed1995

Analysis of perforin expression in human peripheral blood lymphocytes, CD56+ natural killer cell subsets and its induction by interleukin-2.

In this study new evidence is obtained by the use of an anti human perforin monoclonal antibody (mAb), anti P1, concerning the number of perforin positive cells in human peripheral blood lymphocytes (PBL). It is shown that about 23% of PBL is perforin positive and that this percent increases by the treatment in RPMI 1640 medium alone to 33% and with 1000 U r hIL-2 to 46%. Assessment of the cytotoxicity potential of NK cells from PBL, freshly isolated and treated, against tumor cell line K562 by the standard NK cell 4-hr 51-chromium release assay, indicates a significant enhancement in their cytotoxicity. By FACStar sorting and analysis of the CD56+ NK cell population new evidence is obtained which shows that about 25-30% of this population represents the CD56bright+ subset, while 70-75% represents the CD56dim+ subset. As the two subsets were shown to differ functionally they were stained with anti P1 for the evaluation of perforin content and it was found that both of them are positive for perforin from 97-99%, suggesting that the functional difference is not due to perforin content. In this sense, as NK cells are constitutively positive for perforin, the increase in the cytotoxicity of NK cells induced by IL-2 is most likely due to the synthesis and expression of various adhesion molecules on NK cells which increase their cytotoxic potential, as well as, that the detected increase in the number of perforin positive cells by this lymphokine does not belong to NK, but to the T lymphocyte population. The data obtained in this study indicate the possibility of perforin detection in human lymphocytes by an anti human perforin mAb and the change in the number of perforin positive cells after stimulation with interleukin-2.

Antibodies, Monoclonal↗
PubMed1994

One-parent families in Europe: a review.

"One parent families form about 10-15 percent of all families in most industrialized countries. This review examines a selected number of European studies related to one-parent families completed during the 1985-1992 period. The major findings are presented, and implications for further research are included."

Developed Countries↗
PubMed1993

Caring for elderly parents and adult children living at home: interactions of the Sandwich Generation family.

The study presented here analyzed the patterns of demands made on 66 middle-aged women by their elderly parents and their adult children who were living at home. Factor analyses of the reports of family interactions revealed the presence of five adult children-middle-aged parents interaction factors and four elderly parents-middle-aged parents interactions. These patterns were considerably more complex than previous studies of the Sandwich Generation suggested. As expected, socioeconomic status and health of the elderly parents were related to these family interaction factors.

Adult↗