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Biomedical subjects

B Sep-Kowalikowa

Publications and source records attributed to B Sep-Kowalikowa.

12 recordsLinked to original sources
PubMedDate not supplied

[Weight gain during antidepressant therapy].

Changes of weight were assessed within a population of 329 patients with major depressive disorders and neurotic states, treated with amitriptyline, doxepin, insidone and imipramine. It has been found that the most important increase of body weight occurred in the groups of patients treated with amitriptyline and doxepin. In the group of insidone the increase of weight was not so high as in the previous groups. The patients treated with imipramine lost weight in the first three weeks of the treatment. No relationship between the increase of body weight and diagnosis, doses of antidepressants, age, sex and education has been observed.

Adult↗
PubMedDate not supplied

[Alprazolam in the treatment of anxiety disorders and mixed anxiety and depressive disorders. Results of multicenter clinical trial].

Alprazolam is one of the most commonly prescribed psychotropics drug all over the world. This suggests that alprazolam is very effective and safe. A multicentre clinical trial was carried out for assessing its efficacy and side effects. 130 patients suffering from anxiety disorders, mixed anxiety and depressive disorders and dysthtymia were involved in the trial. During 6 weeks they used to take from 1.5 to 2.5 mg. of alprazolam daily. Mental state has been assessed with Hamilton rating scales of anxiety and depression, Montgomery Asberg scale of depression and CGI scales. At the endpoint good recovery was found in 75% of the patients, mild recovery in 19%, and 6% got worse. The effect of treatment depends on individual patients' traits rather than on initial mental state. Adverse events were noted in a half of patients, were not severe and were going down during the treatment. 4.6% of patients dropped out because of adverse events, the others tolerated alprazolam well.

Adolescent↗