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Biomedical subjects

B Shakhov

Publications and source records attributed to B Shakhov.

At least 19 recordsLinked to original sources
PubMed1991

[The drug treatment of cardiogenic shock--our experience].

For the period 1970-1989 in the intensive care unit of the National Center for Cardiovascular Diseases, 178 patients with cardiogenic shock were treated and died. These patients were studied retrospectively. In all patients an acute myocardial infarction was proved clinically and post mortem. The patients were classified into two groups--group A--those treated during the period 1970-1975 and group B--those treated during the period 1985-1989. The analysis of the risk factors and the time of hospitalization since the onset of the clinical symptoms showed no differences between the two groups. In the therapeutic programme of group B new contemporary means and methods, such as dopamine, vasodilators and electrostimulation, were included. This accounts for the longer survival of the patients from this group (about 60% of the patients survived more than 24 h), which allows them a chance to overcome this fatal condition.

Aged↗
PubMed1990

[The diagnostic potentials of spatial velocity ECG in assessing the changes in ventricular depolarization].

The study includes 702 patients (with left ventricular load, myocardial infarction and bundle branch block) and 130 healthy persons. To all these a spatial velocity EKG was made (SVEKG) as well as corrected orthogonal electro- and vectorcardiogram according to Frank, spatial ECG and standard EKG in 12 leads. The indices of the spatial velocity ECG were compared with those of the other methods on the basis of the criteria sensitivity and specificity. In the patients with right ventricular load the indices of the spatial electrocardiography showed the highest sensitivity; in the patients with left ventricular load and bundle branch block the indices of the corrected orthogonal electrocardiography showed the highest sensitivity. In the patients with myocardial infarction the potentials of several methods were equal. The insufficient number of investigations concerning the spatial velocity ECG cannot give a clear view of its potentials and its place in the clinical practice but some of its advantages make it very convenient for preparing a system of automatic analysis of the heart electrophysiological signal.

Bundle-Branch Block↗
PubMed1989

[Complex assessment of the electrophysiological changes in patients with right-ventricular cardiac loading].

In 216 patients with right ventricular cardiac overload the changes of 76 electrophysiological indices were studied--indices of the corrected orthogonal electrocardiogram after Frank, corrected orthogonal vectorcardiogram, spatial electrocardiogram and high-speed spatial electrocardiogram. The patients with right ventricular cardiac overload are divided into two basic groups--patients with systolic and patients with diastolic overload. The indices are assessed on the basic criteria of sensitivity, specificity and realization. Variation analysis as well as statistical comparison with 119 healthy persons are performed. On the basis of the results of the study "sets" of 4 indices each with 97-98% sensitivity are determined, indices from all methods used are included in the "sets". The conclusion is reached of the good possibilities of the electrophysiological methods when a combination of indices with the help of a computer is made.

Adult↗
PubMed1989

[Complex assessment of the electrophysiologic changes in patients with left-ventricular cardiac overload].

130 healthy persons and 146 cardiac patients with left ventricular cardiac overload were examined by 4 electrophysiologic methods: corrected orthogonal electrocardiogram according to Frank, corrected orthogonal vectorcardiogram, space electrocardiogram, high-speed space electrocardiogram. 76 indices were examined. The cardiac patients were classified into two basic groups: patients with systolic overload and patients with diastolic overload. By variational analysis, performed in all patients, statistically significant differences were found between the cardiac patients and the healthy persons. On the basis of the criteria sensitivity, specificity and assessment of realization the best indices for every method were determined. In order to improve the sensitivity "sets" with sensitivity of 91-96% are established by mathematical calculations. The "sets" are made up of 4 indices from different methods and are suitable for inclusion in computer programs.

Aortic Valve Insufficiency↗
PubMed1987

[Association of Ebstein's disease and aortic coarctation].

The rare case of a 58 years old male patient with a combination of Ebstein's disease and coarctation of the aorta is reported. The patient presented and died with manifestations of cardiac and respiratory failure. The post mortem examination revealed the combination of Ebstein's disease and coarctation of the aorta. The analysis of the clinical and paraclinical data points to an atypical course of the disease probably due to the opposite hemodynamic characteristics of the two congenital heart diseases.

Aorta↗
PubMed1982

[Determination of the effect of furanthril on myocardial infarct lesion size according to precordial electrocardiogram (mapping) and enzyme activity findings].

The ECG Mapping from 30 precordial points in 56 patients with recent anterior transmural infarctions was followed up as well as the level of the enzymes, acid phosphokinase, SGOT and LDH-iso during the first 6 days after the origination of the cardiac infarction. Thirty six patients were treated according to the generally adopted treatment schedule of cardiac infarction (group without furanthril) and 20 patients were administered, in addition to the generally adopted schedule, one tablet furanthril daily during the first six days (group with furanthril. Though no manifested discrepancies were observed in the indices studied in both groups (without and with furanthril)--in patients administered furanthril systematically--a better manifested drop was found in ECG Mapping indices and the enzyme activity in the course of the cardiac infarction, as compared with the group without furanthril. In some of the cases that tendency was with a statistical significance. According to clinical data, extensive lesion of myocardium and cardiac rupture were more frequently found in the group without furanthril whereas grave rhythm disorders were more frequent in the group with furanthril. The systematic administration of furanthril, in the first several days after the origination of the cardiac infarction, revealed some favorable tendencies in its course (possible restriction of lesion zone according to ECG Mapping data, restriction of necrosis according to enzyme activity data), but, at the same time, the unfavourable arrhythmia became more frequent, necessitating the control of rhythm and electrolytes as well as timely antirhythm treatment.

Aged↗
PubMed1981

[Diagnostic value of the spatial velocity electrocardiogram in myocardial infarct].

The object of the study were 220 patients with a myocardial infarction, confirmed clinically, enzymatically and electrocardiographically. Seventeen indices were studied, processed via variation analysis with 8 sites of the infarction alterations. The results were compared with those in subjects with intact hearts, examined and described by the authors in another study with the aid of the same devices. The size of the maximum space velocity is most significantly decreased in all myocardial sites. The results, summed up for anterior and posterior-inferior sites are also presented. The sensitivity of some of the indices was determined as well as the correlation dependence with the level of serum creatine-phosphokinase. Highest proved to be the sensitivity of the maximum space velocity (100%), an index correlating with the level of serum creatine-phosphokinase between --0.60 and --0.64. Conclusions were drawn referring to some potentialities for a further application of the method.

Adult↗
PubMed1980

[Clinical biochemical changes in ischemic heart disease: hyperuricemia as a risk factor].

One hundred and sixty patients with IHD were examined--73 males and 87 females, average age for males--58.58 +/- 12.69 and for females--59.65 +/- 7.76. Elevated levels of uric acid were found in 51.5 per cent. The correlation analysis showed a positive correlation dependence between total fats and uric acid, between cholesterol and uric acid as well as between total protein and uric acid and reverse dependence between uric acid and alpha 2-globulines, beta and gamma globuline fractions. The results from the investigations carried out provided grounds to admit hyperuricemia to be one of the risk factors of IHD.

Blood Glucose↗
PubMed1979

[Planimetric analysis of ventricular depolarization on Frank's corrected orthogonal electrocardiogram in healthy hearts and in patients with ventricular loading].

Nineteen planimetric indices of 110 cardiac healthy subjects, 141 patient with left ventricle loading and 136 patients with right ventricle loading are analyzed. On the base of the variation analysis and determination of statistically significant differences, it was established that in right-ventricular loading the following indices deviate from the norm: ASX, AQZ, AQRSX, AQRSz, SAQRSx, SAQRSy, SAQRSz, SAS, SAQRSg, whereas in left-ventricular loading -- ARx, ARz, AQRSx, AQRSz, SAQRx, SAQRSy, SAQRz, SAR, SAQRSg. At a second stage, the sensitivity of the separate indices from the groups with left ventricular and right-ventricular loading was amalyzed, as well as the separate subgroups (pulmonary stenosis, aortic stenosis, mitral stenosis, interauricular defect, arterial hypertension, mitral or aortic insufficiency. The results were compared with those of axial indices, obtained from another investigation of the authors. The planimetric analysis was established to be more complex than the axial and the index SAQRSg to be with the best sensitivity in the cases with hemodynamically lightly loaded musculature.

Analysis of Variance↗
PubMed1978

[Comparison of precordial electrocartography with pathologicoanatomic data on 20 patients with recent myocardial infarct].

In 20 patients with recent myocardial infarction, that died till the 40th day after the onset of the disease, a comparison is made of the data from the pathologoanatomical findings with the indices from the precordial electromapping. The changes in the ST segment of the precordial electromapping correlate, to a significant extent, to the weight of the infarction zone in patients with interior site of the myocardial infarction (sigmaST r = 0.89, p less than or equal to 0.01; nST r = 0.62, p less than or equal to 0.01). The indices from the precordial electromapping characterizing the changes in depolarization, are with a considerable less degree of correlation dependence to the weight of the enfarcted zone in the same patients (nQS r = 0.62, p less than or equal to 0.62, p less than or equal to 0.05; sigmaAR r/0.45, p less than or equal to 0.05). In patients with posterior and/or inferior site of the infarction the correlation dependence to the indices from the precordial electromapping is less manifested.

Adult↗
PubMed1978

[Precordial electrocartography (mapping) in cardiac infarct].

After a detailed literature survey the authors share the results from the precordial electromapping with the registration of 30 points upon the chest in 34 patients with ischemic heart disease (30 with transmural infarction and 4 with intermediary syndrome). The following indices were followed up: sigmaST (the sum of the elevation of ST segment measured at 60 msec of the S deflection recording) and the index nST (the sum of the points with an elevation greater than 0.1 mV/1 mm). Both indices well correlate to the level of blood creatine phosphokinase, determined 24 hours after the examination. Due to the close degree of correlation dependence, the two indices are interchangable for the practice. The precordial electromapping reflects the degree of extent of the "myocardial hypoxia" as well as the degree of the disturbed biological activity of the tissues, affected by the myocardial infarction.

Acute Disease↗
PubMed1977

[Diagnostic value of Frank's corrected orthogonal electrocardiogram].

The changes in the corrected orthogonal electrocardiograms of 411 patients were analyzed: 134 with right ventricle loading, 137 with left ventricle loading and 140 with myocardial infarction (chronic phase). On the base of sensitivity and specificity criteria the indices SXmV, SXmsec and QZmV for the patients with right ventricle loading and RXmV and RZmV for the patients with left ventricle loading proved to be with the highest diagnostic value. Sensitivity is within 19% to 61%. Sensitivity is within 85% and 95% in patients with myocardial infarction (chronic phase), for the different indices depending on the infarction zone. The comparative analyses of the indices of the corrected orthagonal Frank electrocardiogram and the standard electrocardiogram (12 leads) give a certain preference to the indices of the standard electrocardiography.

Cardiomegaly↗