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Biomedical subjects

B Stenquist

Publications and source records attributed to B Stenquist.

At least 19 recordsLinked to original sources
PubMed1997

Five-year results of curettage-cryosurgery of selected large primary basal cell carcinomas on the nose: an alternative treatment in a geographical area underserved by Mohs' surgery.

Mohs' micrographic surgery (MMS) is the recommended treatment for large basal cell carcinomas (BCCs) of the nose. This 5-year follow-up study attempts to evaluate whether curettage-cryosurgery (CC) could be an alternative therapy in a country where optimal resources for MMS are lacking. All patients with a primary nasal or perinasal BCC, 10 mm or larger in diameter, were assessed at a skin tumour clinic. Sixty-one BCCs of non-morphoeiform type were treated with CC. Most of the tumour was removed by careful curettage with different sized curettes. The tumour area was then frozen with liquid nitrogen in a double freeze-thaw cycle. Fifty patients were followed for at least 5 years with only one recurrence. The cosmetic result was good or acceptable in all patients. A thorough curettage followed by cryosurgery could be a safe and inexpensive alternative therapy even for large primary non-morphoeiform BCCs of the nose.

Adult↗
PubMed1997

DNA analysis indicates patient-specific human papillomavirus type 16 strains in Bowen's disease on fingers and in archival samples from genital dysplasia.

Human papillomavirus (HPV) type 16 is casually involved in the pathogenesis of anogenital cancer and has also been demonstrated in some patients with Bowen's disease (BD) on the fingers. From two women with HPV 16 in BD on the fingers, and in archival samples from genital dysplasia, collected as long as 26 years ago, the non-coding region of the virus was amplified by the polymerase chain reaction and sequenced. The HPV 16 DNA sequences found in the finger lesions and in the genital archival samples showed no diversities within single patients. Compared with an HPV 16R reference sequence, one patient showed a unique T nucleotide at position 78, whereas the other patient exhibited T and A nucleotides at positions 7193 and 7521, respectively. In one of the patients, the same strain of HPV 16 was found in a digital tumour 26 years after its clearance from the genital tract. DNA sequence analysis indicated patient-specific HPV 16 strains. Auto-inoculation from the genital tract was favoured as a plausible explanation of why HPV 16 caused BD on the fingers.

Adult↗
PubMed1994

Role of acid secretory response to sham feeding in predicting recurrent ulceration after proximal gastric vagotomy.

The completeness of vagal denervation in determining the long-term outcome of patients with duodenal ulcer disease after proximal gastric vagotomy (PGV) was studied by examining the relationship between the postoperative acid secretory response to sham feeding ('chew and spit' technique) and the subsequent ulcer recurrence rate during a mean follow-up of 7.5 (range 5-15) years. The cumulative recurrence rate of 98 patients analysed prospectively was 11 per cent. Of 22 patients who had incomplete vagotomy as suggested by the sham feeding response, five had a later relapse. This compares with only an 8 per cent relapse rate among those with a secretory response suggesting complete vagotomy. Four patients suffered from a relapse more than 5 years after operation but none had undergone incomplete vagotomy. However, in seven patients with an early postoperative relapse (within 5 years) five had had incomplete vagal denervation (P < 0.05). In this latter group the median time elapsed from surgery until the first recurrence was only 1 year. It is concluded that the early postoperative acid secretory response to a sham feeding stimulus is clinically useful as it allows prediction of the risk of early relapse after PGV. This test may be helpful for the validation of new techniques of vagotomy.

Adult↗
PubMed1993

An automatic computerized bipolar coagulator for dermatologic surgery.

BACKGROUND: The problem with all bipolar diathermy equipment is the adherence of the tissue to the prongs of the forceps. OBJECTIVE AND METHODS: We describe a new computerized bipolar coagulator (Coa-Comp/M) with electronic feedback of the tissue impedance that automatically starts and shuts off coagulation thus preventing overheating, undue tissue damage and sticking of the forceps. The fully automation implies that no footswitch or handcontrol is necessary. The coagulator was tested during 2 years in advanced dermatologic surgery. RESULTS: A log memory recorded the number of coagulations according to effect and coagulation time. A power setting of 16W was appropriate for effective coagulation of most vessels; 99% of the coagulations were faster than 1.3 seconds necessitating automatic control for preventing sticking and charring. CONCLUSIONS: The automatic bipolar coagulator saves time and avoids sticking of the forceps. It is a useful tool in dermatologic surgery demanding repeated coagulations for hemostasis.

Dermatology↗
PubMed1992

Treatment of aggressive basal cell carcinoma with intralesional interferon: evaluation of efficacy by Mohs surgery.

BACKGROUND: Intralesional interferon has shown activity in the treatment of noduloulcerative and superficial basal cell carcinomas (BCC). OBJECTIVE: Our purpose was to study the efficacy of intralesional interferon in the treatment of aggressive BCCs. METHODS: Fifteen patients with histologically proven primary morpheaform or recurrent BCCs were referred for Mohs surgery. They received nine intralesional injections of 1.5 million IU of interferon alfa-2b three times a week for 3 weeks (total dose 13.5 million IU). All tumors were located on the face and measured 7 to 25 mm in diameter. RESULTS: In four patients (27%) no residual tumor was found at surgery. In five (33%) tumor size was reduced by 75%. The remaining six patients (40%) showed no response to intralesional interferon. CONCLUSION: At the dosage used, interferon was able to cure only a minority of aggressive BCCs.

Aged↗
PubMed1990

Effect of inositol hexaphosphate on retention of zinc and calcium from the human colon.

Colonic retention of zinc and calcium was studied after installation during colonoscopy in 11 patients of a solution of 30 mumol zinc, 6.4 mmol calcium and 500 mumol inositol hexaphosphate (phytic acid) labelled with 65Zn and 47Ca. Whole-body retention of the radionuclide at day 13 was 1.0 +/- 1.0 per cent (mean +/- s.d.) for zinc and 4.0 +/- 2.9 per cent for calcium. The retention of zinc but not of calcium was lower than observed earlier under similar conditions from a solution not containing phytic acid and indicates formation of an indigestible complex between phytic acid and zinc. Addition of amino acids to the solution in 3 subjects did not seem to affect the retention of zinc and calcium.

Adult↗
PubMed1988

A criterion for completeness of vagotomy based on basal and vagally stimulated gastric acid secretion after esophagectomy or proximal gastric vagotomy.

The variation in basal acid secretion was determined in 10 patients after resection of the esophagus, an operation resulting in a total transection of all vagal nerves to the abdomen. After recording basal acid secretion over a 3-h period, a 15-min modified sham feeding procedure was performed, and the acid output was studied for an additional hour. The mean basal acid output +2 SD was 0.27 mmol/15 min. The difference between the highest and lowest recorded 15-min output--that is, the oscillation of basal acid output--was calculated for each patient. The mean oscillation of basal acid output +2 SD was 0.58 mmol/15 min. Vagal stimulation accomplished by sham feeding produced no significant increase in acid output above this level. The variation in basal acid secretion was also investigated in 20 duodenal ulcer patients after proximal gastric vagotomy. These patients were insulin-negative and remained asymptomatic during a 7- to 10-year follow-up study. Shortly after the vagotomy, measurement of basal acid secretion over 3 h showed a mean basal acid output +2 SD of 0.58 mmol/15 min. The mean oscillation of basal acid output +2 SD was 0.66 mmol/15 min. On the basis of the oscillation in basal acid secretion after complete vagotomy we propose a new criterion for completeness of vagotomy, namely a response to physiologic vagal stimulation which does not exceed the lowest basal level by more than 0.6 mmol/15 min.

Adult↗
PubMed1987

Do enkephalins participate in vagal activation of gastric acid secretion in man?

The effects of the anticholinergic drug benzilonium bromide and the opiate receptor blocker naloxone, given alone or in combination, on the acid secretory response and on plasma gastrin releasing peptide (GRP) response to sham feeding was tested in eight duodenal ulcer (DU) patients. Naloxone alone had no effect on the acid secretion after sham feeding. Benzilonium reduced basal acid secretion and the acid response to sham feeding but did not abolish the response. The combination of benzilonium and naloxone was not more effective than benzilonium alone. Neither drug, nor the combination had any effect on plasma GRP following sham feeding. It is concluded that enkephalins are unlikely to participate in the acid response to sham feeding in patients with DU.

Adult↗
PubMed1986

Retention of zinc and calcium from the human colon.

Colonic retention of zinc and calcium was studied after installation during colonoscopy of 30 mumol of zinc and 6.4 mmol of calcium labeled with 65Zn and 47Ca, and measurement of the whole-body retention of the radionuclides. After cecal installation in nine patients, retention (day 13) of zinc was 3.5 +/- 2.1% (mean +/- SD) and of calcium 3.5 +/- 2.7%. The calculated mean absorption was 4.1% for zinc and 14.1% for calcium. Application at the hepatic flexure in four patients resulted in a mean retention (day 13) of 1.2% for zinc and 0.6% for calcium. Under prevailing conditions, colonic absorption of zinc is relatively small, compared to the uptake after oral administration. Colonic absorption of calcium could, however, account for a substantial part of the total calcium uptake.

Aged↗
PubMed1985

Vagal stimulation of human gastric bicarbonate secretion.

Gastric bicarbonate secretion in humans was determined in vivo by using a gastric perfusion-aspiration system. A computer calculated the bicarbonate concentration every 30 s throughout the experiment from measurements of the pH and PCO2 in the aspirate. The total bicarbonate concentration was calculated according to the formula of Henderson and Hasselbalch as the sum of free bicarbonate plus the CO2 that was formed during reaction of bicarbonate with hydrogen ions. In 16 subjects basal gastric bicarbonate secretion was 410 +/- 39 mumol/h (mean +/- SEM). After sham feeding using the chew and spit technique to achieve physiologic vagal activation, the gastric bicarbonate secretion rate increased to 692 +/- 67 mumol/h (p less than 0.001). This response of bicarbonate secretion rate to vagal stimulation was independent of the intragastric pH (range 2-7). In 6 subjects the sham-feeding response was almost abolished (88% inhibition) by the anticholinergic drug benzilonium bromide, however, it was unaffected by premedication with indomethacin. The findings demonstrate that the increase in gastric bicarbonate secretion during the cephalic phase of gastric secretion occurs parallel to the increase in acid secretion. It may therefore be regarded as a physiologic response to reinforce the protective mucus-bicarbonate barrier. The response to vagal stimulation seems to be mediated by a muscarinic transmitter and to be independent of intragastric pH and endogenous prostaglandins.

Adult↗
PubMed1985

Axillary hyperhidrosis: A simple surgical procedure.

A simple method for surgical treatment of excessive sweating of the axilla is presented. The procedure, which is performed under local anesthesia on an outpatient basis, is described in detail. After mapping the sweat gland bearing area with crepe paper, the hyperhidrotic area was excised using a bat-shaped excision. The skin was closed without undermining. This method has been used in 14 consecutive patients (28 axillae) resistant to topical administration of aluminum chloride hexahydrate in ethanol. The postoperative results were excellent in 12 patients and were good in 2. There were three minor wound infections and one case of postoperative bleeding. This procedure is suitable for all patients who need surgical treatment for axillary hyperhidrosis and requires no training in plastic surgery.

Ambulatory Surgical Procedures↗
PubMed1985

Colonic transit after fibre supplementation in patients with haemorrhoids.

Patients with haemorrhoids often complain of disturbed defaecation which might correspond either to too slow or too fast colonic transit. Colonic transit was determined using a new technique as the distribution of radiopaque markers on a film after a daily intake of 20 markers over 10 days. Nineteen out-patients with a history of haemorrhoids participated in the study. Colonic transit was measured before and after 6 weeks on a bran preparation (Fiberform, 10 g daily) or an ispagula bulk preparation (Lunelax, 10 g daily) in random order. The variation in the distribution of pellets in the colon within the groups was greater than during treatment with fibre preparations. In both cases a 'normalization' of the transit occurred with fibre. No difference was found between the effect of the two fibre preparations on colonic transit. Thus, such changes in transit could be anticipated when the dietary fibre of the diet is increased according to modern recommended dietary allowances.

Adult↗
PubMed1983

Pitfalls in postoperative testing of the completeness of vagotomy.

The gastric acid response to insulin hypoglycemia represents an effect of several stimulatory and inhibitory mechanisms. In the intact stomach the direct vagal excitation of the acid secreting glands is the predominant mechanism. After vagotomy, however, the balance between the stimulatory and inhibitory mechanisms is unpredictable. Some stimulatory and inhibitory mechanisms are non-vagal, and may after vagotomy result in a false conception of remaining vagal fibers and complete vagotomy, respectively. Sham feeding may be a safer and more reliable test of completeness of vagotomy. A study of the spontaneous variation of basal acid secretion over several hours after vagotomy in 22 patients showed in 15-min samples a maximal range of 0.49 and 0.65 mmol with a P value of 0.05 and 0.01, respectively. A higher range may thus indicate a true acid response to a given stimulus. In 3 patients with an acid response to sham feeding but no acid response to insulin in a dose of 0.2 IU/kg after vagotomy, a repeated test with a lower dose of insulin resulted in an unequivocal acid response. In 4 patients with no acid response to sham feeding and a substantial acid response to insulin after vagotomy, the acid response to insulin was abolished after pretreatment with an adrenergic blocker. The insulin test may thus give false negative and positive information about the completeness of vagotomy.

Animals↗
PubMed1982

Gastric mycosis following gastric resection and vagotomy.

In a prospective five-year follow-up study of 289 consecutive patients subjected to antrectomy and gastroduodenostomy with or without vagotomy, 130 patients underwent gastroscopy. Gastric mycosis was present almost exclusively in patients subjected to combined antrectomy and vagotomy (36%). Gastric acidity seemed to be of only minor or no importance in the development of the mycosis. The residual volume in the gastric remnant was significantly higher in patients with gastric mycosis. The impaired emptying of the gastric remnant is most likely a vagotomy effect and may be the main reason for the development of gastric mycosis. A simple but effective method was developed to evacuate gastric yeast cell aggregates. Gastric mycosis seems to give rise to only slight symptoms, mainly nausea and foul-smelling belching, whereas the reflux of duodenal contents that often occurred in combination with gastric mycosis was more likely to cause gastritis and substantial discomfort.

Bile Reflux↗