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Biomedical subjects

B Stojan

Publications and source records attributed to B Stojan.

At least 19 recordsLinked to original sources
PubMed1978

[Correlations between inflammatory activity, immunoglobulins and complement components in the synovial fluid of patients with rheumatoid arthritis and arthrosis].

In 81 synovial fluids (39 from rheumatoid arthritis and 42 from osteoarthritis patients), levels of IgG, IgM, IgA, and complement components C3, C4, and C3-proactivator were estimated. Lactatedehydrogenase (LDH) was used as the parameter of inflammatory activity. With increased LDH activity, the concentrations of all immunoglobulins rose in both groups. In the complement components, this positive linear correlation was demonstrated only in the osteoarthritic group. In rheumatoid arthritis, the results were best demonstrated by means of a regression type curve of the 3rd degree (p less than 0.01). In low inflammatory activity there was a rise in the level of the complement components. With higher LDH activity (greater than 500 U/l), however, there was a drop in the curve and the positive correlation changed to negative.

Arthritis↗
PubMed1977

[Immunological findings in serum and synovial fluid in patients with rheumatoid arthritis (author's transl)].

Sera and synovial fluid were investigated in 45 patients with rheumatoid Arthritis and 50 patients with osteoarthritis in inflammatory exacerbation (control group). The following tests were performed: IgG, IgM, IgA determinations, complement components C3, C3, C4, C3-proactivator, ceruloplasmin, electrophoresis, LDH and total acid phosphatase. 1. Serum levels of the ceruloplasmin, alpha 1, alpha 2 and gamma fractions of electrophoresis are significantly higher in patients with rheumatoid arthritis than in patients with osteoarthritis. 2. Synovial fluid: a) There is a significantly higher concentration of IgG, IgM, IgA, C3-proactivator and total acid phosphatase in the synovial fluid of patients with rheumatoid arthritis. b) C4 is significantly lower in patients with rheumatoid arthritis. c) Both groups were also compared with the help of a point system. Every patient received a plus point when the following criteria were seen: IgM greater than 150 mg/100 ml, C3 greater than 50 mg/100 ml, ceruloplasmin greater than 35 mg/100 ml, alpha 1 greater than 0.21 g%, alpha 2 greater than 0.44 g%, beta greater than 0.60 g% and gamma fraction on electrophoresis greater than 0.90 g%. Another point was added if the criteria ceruloplasmin greater than 22 mg/100 ml and C4 less than 17 mg/100 ml were simultaneously seen. With the help of this points system 48 out of the 50 osteoarthritis patients (96%) received zero points, one received 1 point and one 2 points, as opposed to the patients with rheumatoid arthritis where 35 out of 45 (78%) received one or more points. d) The differentation is not improved through additional testing of the rheumatic factors.

Acid Phosphatase↗
PubMed1976

[Collagen peptidase in Crohn's disease].

Collagen-peptidase activity in serum was increased in 54 of 71 cases of Crohn's disease. This increase was highly significant (P less than 0.001) compared with the results in a control group (24 cases). Immunosuppressive drugs (corticosteroids, azathioprine) decreased collagen-peptidase activity in the patients with Crohn's disease. On average it was higher than that of patients with sarcoidosis. Further tests are required to establish whether collagen-peptidase activity is of diagnostic value in Crohn's disease.

Adrenal Cortex Hormones↗
PubMed1975

[Possibilities of differentiation of antinuclear antibodies].

Antinuclear antibodies can give diagnostic informations according to their titre values, the belonging to different classes of immune globulins and on the basis of different patterns of immunofluorescence connection. The determination of granulocyte-specific antibodies which frequently appear in progressive chronic polyarthritis further contributes to the differential-diagnostic classification of diseases of the connective tissue. An antibody against extractable nuclear antigen is specific for the so-called mixed connective tissue disease, an antimitochondrial antibody for the pseudo-LE-syndrome. Moreover, the own examinations resulted in a particularly high and frequent ability of complement fixation of the antinuclear factors in systematic lupus erythematosus and sclerodermy. In contrast to this in the progressive chronic polyarthritis the complement fixation was clearly more insignificant.

Antibodies, Antinuclear↗
PubMed1975

[The significance of gold serum level determinations during chrysotherapy in rheumatoid arthritis (author's transl)].

The determinations of gold levels in serum of patients with rheumatoid arthritis allow an exact monitoring of chrysotherapy. The atomic absorption spectrophotometry turned out to be superior for clinical use when compared with the neutron activation analysis. Under the conventional gold therapy serum levels increase with repetitive application achieving on maintenance therapy levels, which are in some cases under the recommended levels for effective therapy. The comparison of the clinical response of prolonged gold applications and serum levels revealed for instance that recurrent acute episodes of arthritis are more often with levels of 0.5 ppm or less, than with levels of 1.0 ppm or more. To what extent high dose therapy can increase the efficiency of chrysotherapy should still be determined, it should however be considered that with increased gold levels also more adverse reactions are to be expected. The predominant indication to determine serum gold level in the case of rheumatoid arthritis is the lack of any response to gold application. The serum gold level determination allows to differentiate between insufficient dosage and total ineffectivity of gold.

Arthritis, Rheumatoid↗