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Biomedical subjects

B Sundin

Publications and source records attributed to B Sundin.

25 records · Page 2Linked to original sources
PubMed1985

Aberrations in lipoprotein lipids in men with coronary artery disease and the influence of obesity, smoking and beta-adrenoceptor blocking drugs.

In this study 74 men, 40-60 years old, with incapacitating angina pectoris and angiographically verified coronary artery disease (CAD) were compared to an equal number of randomly sampled healthy men matched for age, occupation and place of living. Obesity and smoking were more common in patients than in controls. The patients had elevated cholesterol (C), triglycerides (TG), and phospholipid (PL) levels dependent on raised concentrations of these lipids in the VLDL and LDL. The C and PL levels in the HDL fraction were decreased. Obesity had a significant influence on the VLDL and HDL levels. Also after taking this influence into account, the CAD patients had higher VLDL and LDL levels and a lower HDL concentration than the controls. Furthermore, regardless of the influence of the TG concentration, the HDL level was reduced in the patients. Smoking habits had no significant influence on the lipoprotein levels. Treatment with beta-adrenoceptor blocking drugs was not associated with any significant alteration of the VLDL or the HDL level. The results strengthen the importance of lipoprotein aberrations as risk factors for coronary heart disease also if observed in association with obesity, smoking and treatment with beta-adrenoceptor blocking drugs.

Adrenergic beta-Antagonists↗
PubMed1985

Effects of short-term exposure to ambient nitrogen dioxide concentrations on human bronchial reactivity and lung function.

Eight normal and 8 asthmatic subjects were exposed to NO2 in a modified body box for plethysmography during 20 min at 0,230,460 and 910 micrograms/m3 on 4 separate days. Bronchial reactivity (histamine inhalation test) was measured after exposure to air alone and to 910 micrograms/m3NO2. Airway resistance (Raw), thoracic gas volume (TGV) and specific airway resistance (SRaw) were measured before, during and after exposure. The bronchial reactivity of the asthmatic subjects increased significantly (p = 0.04) by 20 min exposure to 910 micrograms/m3 NO2. In the non-asthmatic group the airway resistance increased significantly (p = 0.03) after 20 min exposure to 460 micrograms/m3 NO2 and decreased significantly (p = 0.01) after 20 min exposure to 910 micrograms/m3 NO2. In the asthmatic group the trend in airway resistance was the same but not statistically significant. In the latter group TGV was significantly decreased (p = 0.02) during exposure to 910 micrograms/m3 NO2. Short term NO2-exposure in concentrations even below 1000 micrograms/m3 seems to have effects on human bronchial reactivity and lung function.

Adolescent↗
PubMed1984

Immunotherapy with alginate-conjugated and alum-precipitated grass pollen extracts in patients with allergic rhinoconjunctivitis.

In order to compare the safety and the efficacy of two grass pollen extracts made from the same starting material, i.e. equal proportions of cocksfoot and timothy, a 3-year study was made on patients with hay fever. One product was a dialysed aqueous extract of pollens which was chemically conjugated to activated sodium alginate ( Conjuvac ). The other was a pyridine-extracted alum-precipitated crude extract (Allpyral). Forty patients with classical hay fever were admitted to the study. All gave positive result to prick and nasal/conjunctival testing with extracts of both cocksfoot and timothy grass. Thirty-five patients completed all 3 years of the study. Seventeen/eighteen Allpyral-treated and 17/17 Conjuvac -treated patients were subjectively improved. There was no significant difference in symptom scores between the two groups. Challenge tests showed a tendency to reduced sensitivity to allergen in the Conjuvac -treated but not in the Allpyral-treated group. The median values for specific IgG and IgE showed the same pattern of reaction as seen in earlier studies of pollen hyposensitization. There was, however, a greater increase of grass-specific IgG in the Conjuvac -treated patients. No serious adverse effects were seen in any of the treatment groups, but there were slightly fewer side effects in the Conjuvac group.

Adolescent↗
PubMed1983

Is there not a strong relationship nowadays between caries and consumption of sweets?

The aim of the study was to assess the relationship between the consumption of sweets in the preceding three years and the occurrence of proximal caries in the posterior regions of 15-year-old schoolchildren. Information on proximal restorations, excluding the mesial surface of the 1st molar, was obtained from records of about 1,700 children. Thirty children with 0-2 restorations and another 30 with 6-8 were randomly selected, together with the 22 children who had 12-14 restorations. Later, recent bitewing radiographs were used to register the total number of DF surfaces in the relevant regions. The children were interviewed about average consumption of sweets: amount, money spent and frequency. The subjects were cross-tabulated according to the variables amount and frequency. The dependence of cost on each of these variables was found to be statistically significant. Combinations were constructed to give three consumption classes. The mean values of DF surfaces for the three classes appeared in a logical order but, owing to a wide dispersion around the means, the correlation between individual DF surfaces and consumption of sweets was statistically not significant. It was concluded that nowadays the consumption of sweets does not seem to be as strong a factor for the occurrence of caries as it used to be.

Adolescent↗
PubMedDate not supplied

Specific airway conductance and airway conductance-lung volume curves in normal and asthmatic subjects.

Airway conductance (Gaw) depends on lung volume (TGV). An approximate correction for this volume dependence can be obtained by calculating specific airway conductance (sGaw = Gaw-TGV). In this study, Gaw-TGV curves were compared with sGaw in 30 healthy and 20 asthmatic subjects who were studied by body plethysmography. Gaw, TGV and sGaw were measured five times at three to five different lung volumes. sGaw was dependent on TGV, the regression having a negative slope (-0.24 and -0.27 kPa-1.s-1.l-1, in the group without and with asthma, respectively). A change in TGV by 1 l caused a 9 and 11% decrease in sGaw, respectively. Bronchial obstruction induced by histamine inhalation in the asthmatic subjects increased the dependence on TGV by sGaw, now with a positive slope. Thus, a change in TGV by 1 l caused a 20-100% increase in sGaw, depending on the degree of airway obstruction. The Gaw-TGV curve was approximately linear around the resting lung volume. The coefficient of variation in determining the slope of the Gaw-TGV curve was as high as 110 and 153% in health and asthmatic subjects, respectively. It is concluded that sGaw, although rapidly determined, has a systematic error in its correction of lung volume dependence, which the Gaw-TGV curve does not. The Gaw-TGV curve therefore has advantages in research work, but since its construction is time consuming it is hardly suitable in clinical practice.

Adult↗