PubMed Health⌕ Search

Biomedical subjects

B Swanson

Publications and source records attributed to B Swanson.

At least 37 records · Page 2Linked to original sources
PubMed1990

Dementia & depression in persons with AIDS: causes and care.

1. Nurses who care for AIDS patients are challenged to effectively manage two common problems: AIDS dementia complex (ADC) and depression. 2. Nurses can briefly assess certain neuropsychological functions related to ADC and differentiate dementia from depression. 3. Nursing interventions to manage the behaviors associated with ADC and depression can ensure patients' safety and promote the quality of their lives.

AIDS Dementia Complex↗
PubMed1989

Neonatal hyperviscosity association with lower achievement and IQ scores at school age.

A longitudinal study was conducted to determine whether the early neurologic and motor impairment observed in children with neonatal polycythemia and hyperviscosity persisted into school age. Forty-nine children who had neonatal polycythemia and hyperviscosity were evaluated at a mean age of 7 years. Of these, 21 (group 1) received a partial plasma exchange transfusion, whereas 28 (group 2) received symptomatic care. Forty control children (group 3) with a normal neonatal hematocrit were also evaluated. Testing consisted of a battery of measures to evaluate IQ, achievement, neuromotor function, and gross and fine motor skills. Maternal education and IQ were also assessed to avoid potential confounding by differences in the home environment. The neonatal course of the children with polycythemia and hyperviscosity was characterized by an increased number of problems, including hypoglycemia and cyanosis. At 7 years of age, the 49 children who had hyperviscosity (groups 1 and 2) had significantly lower "spelling" and arithmetic achievement test results and gross motor skill scores. Scores for reading, visual motor integration, and neurologic signs did not differ significantly from group 3. Maternal IQ scores were similar for both groups. Left-hand preference was seen in 14% of group 1 and 2 children and 7% of group 3 children (not significant). The scores for IQ, achievement, neuromotor function, and visual motor integration were compared for the hyperviscosity group (groups 1 and 2) and the control group (group 3) by multivariate analysis of variance with sex and hyperviscous group as independent variables and maternal education and maternal IQ as covariates (P = .040).(ABSTRACT TRUNCATED AT 250 WORDS)

Achievement↗
PubMed1986

The prevention and reversibility of tissue non-enzymatic glycosylation in diabetes.

The time course of non-enzymatic glycosylation (NEG) of liver, kidney, tail collagen, and haemoglobin was studied in diabetic rats. Increased NEG of liver, kidney, and collagen was detectable within 4 weeks of diabetes. The abnormal NEG of liver, kidney, and haemoglobin present after 4 weeks of untreated diabetes could be normalized by 4-8 weeks of intensive insulin therapy given by continuous subcutaneous infusion. However, the same treatment was ineffective in reversing the abnormal NEG and thermal stability of tail collagen. The differences in the development and reversibility of these tissue changes may be due to different tissue turnover rates. Insulin therapy, given from the onset of diabetes, was effective in preventing the development of collagen abnormalities. This suggests that early and vigorous treatment of diabetes is necessary to prevent collagen changes which are potentially irreversible.

Animals↗
PubMed1986

Abnormalities of granulation tissue and collagen formation in experimental diabetes, uraemia and malnutrition.

The formation of granulation tissue and collagen was studied in rats made diabetic with streptozotocin. Granulation tissue was harvested from the inside of steelmesh cylinders implanted in the back of diabetic and control animals. Four weeks after implantation there was a reduction in the quantity of granulation tissue and its collagen content in diabetic animals compared to controls. Rats with renal failure or malnutrition but no diabetes also formed less granulation tissue but in these animals the content of collagen in the granulation tissue was normal. These results suggest that the decrease of collagen, but not granulation tissue, in diabetes is a relatively specific phenomenon which was not due to the toxic effects of streptozotocin as the changes were prevented by insulin treatment. The hydroxyproline/proline ratio of diabetic collagen was found to be normal, excluding defective hydroxylation of proline as an important factor in the reduction of collagen in diabetes. Treatment with an aldose reductase inhibitor did not prevent the abnormalities of granulation tissue and collagen in diabetes, making it unlikely that increased activity of this enzyme played an important pathogenetic role. The observed reduction of granulation tissue mass and collagen content in diabetes may be important factors in the impairment of wound healing in diabetes.

Aldehyde Reductase↗
PubMed1970

Studies on Immunity in Anthrax XII. Requirement for Phosphate for Elaboration of Protective Antigen and Its Partial Replacement by Charcoal.

Retention of protective antigen on columns of diethylaminoethyl cellulose was inhibited by the 0.01 m phosphate salts in the standard growth medium. Reduction in the concentration of phosphate to 0.001 m allowed satisfactory retention of antigen on diethylaminoethyl cellulose but decreased significantly the elaboration of antigen during growth of the cultures. Growth remained normal at phosphate concentrations as low as 0.0001 m. Inhibition of antigen elaboration in media containing reduced concentrations of phosphate was overcome by addition of 0.006% (w/v) charcoal. It is suggested that antigen elaboration, like encapsulation of virulent strains, is stimulated in the presence of an adsorbent. However, a nonencapsulated strain derived from an F mutant exhibited the same requirement for an adsorbent as nonencapsulated strains derived from the parent strain.

Journal Article↗
PubMedDate not supplied

The impact of psychosocial factors on adapting to physical disability: a review of the research literature.

Physically disabled persons are challenged to cope with a wide range of stressors in maintaining meaningful lives. Adjustment depends, in part, on psychological and social factors that promote effective coping with old and new demands. This article is a review of current research on the relationship of social support, self-concept, locus of control, and hardiness to the adjustment of persons with physical disabilities. Implications and a psychosocial assessment guide are presented to help rehabilitation nurses evaluate patients' psychosocial status and formulate interventions.

Adaptation, Psychological↗
PubMedDate not supplied

Body composition in HIV-infected women.

Although loss of lean body mass is a common complication of human immunodeficiency virus (HIV) infection that can occur across the disease trajectory, few studies have characterized the body composition of HIV-infected women. We used bioelectrical impedance analysis to characterize the body composition of HIV-infected (n = 56) and uninfected (n = 12) women who were matched on percentage of ideal body weight. The HIV-infected women did not differ from the uninfected women by height-adjusted fat mass or body cell mass. Intergroup comparisons among the HIV-infected women showed that underweight women had significantly less fat mass than did normal-weight women but did not significantly differ with respect to body cell mass. Among all HIV-infected women, CD4(+) lymphocyte count was positively correlated with fat mass (r = 0.32, P = 0.01) but not with body cell mass. No significant correlations were found between any body-composition parameter and plasma viral load. Our findings suggest that, unlike men, HIV-infected underweight women show a preferential loss of fat mass and a relative preservation of body cell mass. This altered pattern of weight loss may relate to higher premorbid fat stores in women and/or hormonal differences.

Adipose Tissue↗
PubMedDate not supplied

Complementary and alternative therapies to manage HIV-related symptoms.

Persons with HIV infection report substantial use of complementary and alternative medical (CAM) therapies for symptom management. Anecdotal reports from patients indicate that CAM approaches are helpful; however, there is limited scientific information on the safety and efficacy of these therapies in the HIV population. The purpose of this review is to critically appraise the scientific evidence for selected CAM therapies that are used by HIV-infected persons to manage three common symptoms: nutritional alterations, pain, and depression.

Complementary Therapies↗
PubMedDate not supplied

Immunological and virological markers of HIV-disease progression.

This review, based upon scientific literature, evaluates a number of immunological and virological markers for their usefulness as prognostic indicators for progression of HIV disease. The most widely studied marker, the CD4 positive T lymphocyte count, is perhaps the best single indicator of stage of illness. Serum factors such as neopterin and beta-2 microglobulin, alone and in combination with CD4 cell counts, have been shown to have good predictive value. Measurement of viral burden by quantification of viral RNA levels in plasma and immune cells also holds promise for following disease progression. It is recommended that a combination of these factors be monitored in evaluating stage of illness and responses to therapy in HIV-infected persons.

Biomarkers↗
PubMedDate not supplied

Cortisol upregulates HIV p24 antigen production in cultured human monocyte-derived macrophages.

HIV infection is associated with hypercortisolemia. Since glucocorticoids have been shown to stimulate the replication of several viruses, we examined the effects of cortisol on HIV replication in cultured monocyte-derived macrophages (MDM), a cell type that has been proposed to serve as a viral reservoir. Our data revealed that physiological concentrations of cortisol upregulate viral replication in MDM. Because the dose-response curve for cortisol on HIV replication in vivo is not known, the clinical relevance of these findings remain uncertain. Clinical studies are needed to characterize the effects of corticosteroid therapy on viral burden in vivo.

Cells, Cultured↗
PubMedDate not supplied

HIV-associated distal symmetrical polyneuropathy: clinical features and nursing management.

DSPN is a common manifestation of HIV infection and/or its treatment that can have adverse effects on quality of life and functional status. The pathogenesis remains unclear but likely involves the elaboration of neurotoxic inflammatory cytokines and their metabolites. DSPN is often refractory to available pharmacological treatments, although new treatments involving NGF hold promise for effecting sustained symptom relief and reversing axonal degeneration. Further research is needed to determine the efficacy of nonpharmacological treatments, such as cognitive-behavioral therapies, to alleviate DSPN-associated pain.

HIV Infections↗
PubMedDate not supplied

Bioelectrical impedance analysis (BIA) in HIV infection: principles and clinical applications.

Wasting is a common manifestation of AIDS that diminishes quality of life and is predictive of death. Body composition changes can occur in asymptomatic HIV infection, suggesting that early detection and treatment could potentially prevent the downward spiral to serious wasting. Bioelectrical impedance analysis (BIA) is a method for estimating body composition that is gaining widespread use among HIV-infected populations. In this article, the principles underlying BIA and its appropriate applications and limitations in HIV/AIDS are described.

Body Composition↗