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B T Collins

Publications and source records attributed to B T Collins.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Chlorinated aliphatic hydrocarbons used in the foods industry: the comparative pharmacokinetics of methylene chloride, 1,2 dichloroethane, chloroform and trichloroethylene after I.V. administration in the rat.

the pharmacokinetics of methylene chloride, CH2Cl2, 1,2-dichloroethane, CH2ClCH2Cl, chloroform, CHCl3 and trichloroethylene, CHCl.CCl2 were determined, after i.v. administration to male Wistar rats, at five dose levels ranging from 3 to 15 mg/kg. The elimination of chloroform followed a three compartment model at all dose levels. The remaining compounds gave data that fitted a two compartment model at low doses which changed to a three compartment model at higher dose levels. All data were fitted to a two and three compartment model and the model that gave the best fit was selected on the basis of the smallest residual mean squared error. Very few differences, apart from the change in the nature of the pharmacokinetic model, were seen in the rate coefficients over the dose range tested. At the highest dose level, the rates of uptake and elimination for the major tissues were similar to those observed for the blood but were much slower for the perirenal fat.

Animals↗
PubMedDate not supplied

Fine needle aspiration of medullary carcinoma of the thyroid. Cytomorphology, immunocytochemistry and electron microscopy.

OBJECTIVE: To analyze of medullary carcinoma of the thyroid (MCT) diagnosed by fine needle aspiration (FNA) utilizing cytomorphologic features and ancillary studies. STUDY DESIGN: Nine cases of MCT were collected, and the cytomorphologic findings were reviewed. Additionally, immunocytochemistry, immunoelectron microscopy and ultrastructural examination results were reviewed for selected cases. RESULTS: In five cases, loose groups predominated over single cells, whereas single cells predominated in three cases. One case showed only highly cohesive groups of cells. Most cells were round to oval, and every case had some degree of plasmacytoid morphology. Spindle-shaped cells were predominant in one case and were occasionally noted as a subpopulation in the other cases. Binucleation was noted in seven cases, and scattered, abnormally large nuclei were identified in five cases. The cytoplasm was moderate to abundant and delicate in all cases. Routine immunocytochemical staining for calcitonin and chromogranin was positive in three of four cases, and staining positive for the markers was detected by immunoelectron microscopy in two cases. In four cases, electron microscopy revealed neurosecretory granules. CONCLUSION: The cytomorphologic appearance of medullary thyroid carcinoma is highly distinctive, and the diagnosis can be corroborated by appropriate ancillary studies.

Adult↗