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Biomedical subjects

B T Palermo

Publications and source records attributed to B T Palermo.

10 recordsLinked to original sources
PubMed1980

New instrumentation for determining flexure breaking strength of capsule-shaped tablets.

New instrumentation to measure the flexure breaking strength of capsule-shaped tablets was developed. It consisted of a mechanical linkage to apply the breaking load at a uniform rate and a strain-gauge instrumented cantilever beam to convert the load to a proportional millivolt response on a recorder. A recorder tracing was obtained of increasing load with time, with a break in the tracing denoting the tablet's flexure breaking strength. Measurements were made for different tablet hardnesses, and a plot of tablet hardness versus flexure breaking strength yielded a profile of the mechanical strength of the tablet. The instrumentation was shown to have application for determining the effects of tablet thicknesses, tablet ingredients, tablet sizes, cup depths, and bisect dimensions on tablet strength.

Capsules↗
PubMed1979

Reliability of Arrhenius Equation in predicting vitamin A stability in multivitamin tablets.

Shelflife predictions of vitamin A stability in multivitamin tablets were calculated based on data obtained from the analyses of six multivitamin tablet preparations by the classical Arrhenius treatment. This approach gave excessive variation in the predictions. The same data were treated by a modified Arrhenius method, which reduced the variation. Long-term room temperature data show that incorrect slopes were predicted in three of the six sets of data with the modified approach. The data indicate that erroneous predictions can result when applying the Arrhenius treatment to accelerated data and that this approach should be used with extreme caution in establishing the expiration date of a multivitamin tablet product, especially where the limiting ingredient for expiration dating is a preprocessed raw material and not a single-entity chemical.

Drug Combinations↗
PubMed1977

Physical form as a determinant of effect of buffered acetylsalicylate formulations on gi microbleeding.

During a 48-day period, 12 male dogs received four buffered sodium acetylsalicylate formulations, quantitatively virtually identical (a homogenenous disintegrating swallow tablet, a swallow tablet in which the sodium acetylsalicylate was contained in a dissolving core, an encapsulated powder, and an aqueous suspension), at 650-mg aspirin equivalent doses twice daily during four 7-day treatment periods (each preceded by a 5-day period of no treatment) in a complete changeover fashion. Mean daily fecal blood losses of 0.75, 1.37, 1.43, and 2.89 ml were observed in the 12 dogs during treatment with the aqueous suspension, the homogeneous tablet, the encapsulated powder, and the core tablet, respectively. These findings indicate that the physical form of buffered acetylsalicylate formulations is a critical factor in the effect of such formulations on GI microbleeding.

Animals↗