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B Tavolato

Publications and source records attributed to B Tavolato.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid.

In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial meningitis; granulocyte-macrophage (GM)-CSF was never detected. These findings suggest that M-CSF may play an important intrathecal immunoregulatory role in neoplastic and infectious diseases of the central nervous system.

Animals↗
PubMedDate not supplied

Immunological markers in the cerebrospinal fluid of HIV-1-infected children.

Several immunological abnormalities were detected in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected children. Intrathecal synthesis of immunoglobulins, free light chains (FLC), IL-1 beta, IL-6, and M-CSF were demonstrated both in asymptomatic children and children with subacute encephalopathy. Our findings further support the hypothesis that an immunopathological subclinical process within the central nervous system (CNS) may be an early manifestation of acquired immunodeficiency syndrome (AIDS). Cytokine detection in the CSF may represent a useful diagnostic tool in evaluating the outcome of HIV-1-infected patients.

AIDS Dementia Complex↗
PubMedDate not supplied

Alzheimer's disease and senile brains: an immunofluorescence study.

The results obtained with direct immunofluorescence techniques on normal, senile and Alzheimer's disease brains are reported. The antisera used were directed against C3c, IgG (gamma chain), IgG Fc., kappa and lambda light chains and anti-Ig (total). The brain samples were prepared in different ways: formalin-fixed and paraffin embedded; fresh frozen samples and alcohol fixed, paraffin-embedded samples. The images obtained with the different processing methods did not coincide. In order to obtain a more complete picture, we suggest the use of different methods on the same samples. In Alzheimer's disease brains, abundant but probably not monoclonal Ig antigenic determinants were found. Ig were found diffusely in the tissue, connected to amyloid (both in senile plaques and blood vessel walls), in glial cells and neurons. The significance of such data in relation to the genesis of brain amyloid are discussed.

Adult↗
PubMedDate not supplied

[Neoplasms of the brain stem: clinico-pathologic correlations].

We report here the clinico-pathological data about 4 patients with brainstem tumors. Clinical symptoms were variable but allowed a correct topical diagnosis. On the other hand, all the neuroradiological examinations, especially CT scan of the brain, resulted always negative or without diagnostic value. Good results for the diagnosis were given by pneumoencephalography and ventriculography. The neuropathological examination revealed one spongioblastoma, two malignant astrocytomas and one pontine metastasis of carcinoma of esophagus. Diagnostic troubles, even with modern and sophisticated techniques are stressed here. The clinician should not overweight negative results obtained with these techniques and every time include in the differential diagnosis brainstem tumors.

Adult↗
PubMedDate not supplied

[Instrumental diagnosis of multiple sclerosis: correlation between electrophysiologic and cerebrospinal fluid findings].

Since a few years the technique of evoked potentials (PE), both visual (VERs) and acoustic (BAERs), of the encephalic trunk has been introduced in the diagnosis of SM. The electrophysiologic data thus obtained are usefully completed by liquor's ones, often allowing a precocious diagnosis of this disease. In this work the authors compare the results of liquor analyses (dosage of the relation IgG/total proteins; electrophoretic research of Oligoclonic Bands) with those of the PE in 28 patients with suspect SM. The high positive percentages of BAERs (78.8%) and of VERs (90%) in certain multiple scleroses, as well as in suspect multiple scleroses (53.6% and 82.1% respectively), prove the high sensibility of these techniques. The positive percentages of liquor analysis appear to be slightly inferior as to those of evoked potentials, even if these differences are not statistically significant. Besides the authors noticed a high degree of accordance between PE and liquor anomalies (in the cases of defined SM the patients with altered liquor presented at least an altered PE).

Brain Stem↗
PubMedDate not supplied

[Anatomo-clinical study of 4 cases of Jakob-Creutzfeldt disease (spongiform encephalopathy)].

Four anatomo-clinical cases of Creutzfeldt-Jakob disease (spongiform encephalopathy) are described. In 3 cases the correct diagnosis was made while the patients were living. The most important diagnostic elements are the following: rapid evolution of a presenile or senile dementia, with neurological symptoms unusual in the Alzheimer's disease. The importance of EEG for the diagnosis of Creutzfeldt-Jakob disease is confirmed: however the onset of the typical EEG abnormalities was very late in its manifestation, the CT alterations are in general absent or very limited. The pathological alterations are aspecific. The spongiform process was sometimes scarce or limited to specific cerebral areas.

Aged↗