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Biomedical subjects

B Temperville

Publications and source records attributed to B Temperville.

9 recordsLinked to original sources
PubMed1987

Bicarbonate haemodialysis: an adequate treatment for lactic acidosis in diabetics treated by metformin.

Lactic acidosis in diabetics on metformin therapy is rare but still associated with poor prognosis. The authors report here five cases. Three patients were initially with a cardiovascular collapse and all had an acute renal failure. Sodium bicarbonate haemodialysis therapy led to a dramatic improvement. Consciousness and hemodynamic status recovered rapidly. Severe metabolic and blood gases derangements were also rapidly corrected. Plasma metformin removal, appreciated by repeated blood samplings in 3 cases, was satisfactory. All patients survived. However, blood metformin levels remained abnormally high at the end of the dialytic therapy. In conclusion, (1) bicarbonate dialysis is an adequate treatment of lactic acidosis observed in diabetic patients treated with metformin since it rapidly corrects the acid-base disorders and partially removes metformin; (2) the sole accumulation of metformin is not sufficient to explain lactic acidosis since this latter might be corrected in spite of persisting high levels of blood metformin.

Acidosis, Lactic↗
PubMed1983

Beta blocker therapy in 125 cases of hypertension during pregnancy.

Over a period of 4 years, a team of obstetricians and nephrologists have used beta-blockers in the treatment of hypertension in high risk pregnancies. One hundred and twenty one patients (125 pregnancies) were treated with this new therapeutic approach: Acebutolol (56 cases), Pindolol (38 cases) and Atenolol (31 cases) were used. In our group of patients, 56% (70/121) had a previous record of hypertension. Treatment was started when diastolic pressure reached 90 mmHg. The mothers showed excellent tolerance and in 95% of cases blood pressure was controlled in a satisfactory manner. Three groups of new-born infants were defined. In 20 infants, the weight was less than 2.5, in 15 infants between 2.5 and 2.8 kg, and in 90 infants more than 2.8 kg. There was no evidence of low Apgar scores, bradycardia or hypotension in the infants. The importance of team management of the patient is emphasised.

Abnormalities, Drug-Induced↗
PubMed1980

[Treatment of hypertension in pregnant women with beta-blockers. 60 cases (author's transl)].

Fifty-nine hypertensive women were treated with beta-blockers during 60 pregnancies. Acebutolol was used in 28 cases, pindolol in 21, atenolol in 10 and propanolol in one. Concomitant administration of dihydralazine was required in 6 cases. In 6 women beta-blockade was started before, and continued throughout pregnancy. Treatment was initiated after the 13th week of gestation in the majority of patients and before the 12th week in two. Twenty women were known to have hypertension long before they became pregnant, and renal disorders were diagnosed in seven. Satisfactory control of blood pressure, with values below 140-90 mmHg, was achieved in 55 cases, and in the same number of cases delivery occurred after 38th week. No clinical or biological side-effects were observed in either mothers or infants. The birth weight was superior to 2500 g in 51 children, including 37 who weighed more than 3000 g. There was only one death in utero. One child born at 35 weeks with multiple malformations and another with meconium ileus also died. Beta-blockers may therefore be safely used to treat most cases of hypertension during pregnancy, provided close supervision is exerted throughout the gestation period.

Adrenergic beta-Antagonists↗
PubMed1978

[Furosemide].

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Acute Kidney Injury↗
PubMedDate not supplied

[Three cases of hereditary xanthinuria: review of the literature (author's transl)].

Xanthinuria is a rare hereditary disorder characterized by a gross deficiency of the enzyme xanthine oxydase resulting in hypouricemia, hypouricosuria and increased serum and urinary oxypurines. Three patients with this disease are presented and the pertinent literature is reviewed. We have demonstrated in one subject the absence of xanthine oxydase activity in a renal fragment. Genetic studies were performed but we do not find any relation between this deficiency of enzyme xanthine oxydase and HLA, Pl, Gm groups.

Adolescent↗