Biomedical subjects

B Todorov

Publications and source records attributed to B Todorov.

15 recordsLinked to original sources

PubMed1990

[The therapeutic effect of nitromint retard on patients with stable angina pectoris].

The antianginal [correction of antidiagnose] efficacy of nitromint retard was studied in 62 middle aged patients with angina pectoris in a 4 week treatment with a 24 h dose of 2.6 mg. Bicycle ergometry [correction of A veloergometria] was conducted before the treatment and at the end of the fourth week. The average number of anginal attacks decreased from 4.0 +/- 1.9 to 1.6 +/- 1.3 during the first week and to 0.0 +/- 0.7 at the end of the 3rd week. The average threshold power increased at the end of the 4th week. Nitromint retard increased considerably the tolerance to physical load and did not increase the consumption of oxygen. The desired effect was achieved in 66.13% of the patients.

Angina Pectoris↗

PubMed1987

[Mechanisms of the lactogenic action of thyroid hormones and nonspecific resistance in ruminants].

Studied was the effect of thyroid hormones on the nonspecific resistance and the milk productivity of ruminant animals in the conditions of hypodynamia and in various functional conditions of the thyroid gland. Both the removal of the thyroid gland (thyroidectomy) and the hypofunction of the gland (as induced by ammonium perchlorate at 10 mg/kg body mass) were accompanied by the drop of the indices characterizing the nonspecific resistance of the animals as well as their milk productivity. The immobilization of lactating ruminant animals (hypodynamia) had a negative impact on the milk producing process, enhanced the incretion of ACTH, lowered the release of thyroid hormones (T3, T4, FT4) and decreased milk productivity, deteriorating the biologic properties of colostrum. The thyroid gland and its hormones (T4, T3) were shown to have a positive effect on milk secretion, raising the activity of the enzyme adenylate cyclase and the amount of the cyclic 3.5 cyclic adenosine monophosphate (cAMP) in the parenchymal tissue of the mammary gland.

Animals↗

PubMed1987

[Total LDH activity and isoenzyme spectrum in experimental Cysticercus ovis infestation of lambs and kids].

Investigations were carried out with 10 lambs and 4 kids at the age of two months, divided into three groups. The test animals of the first group (5 lambs) were infected with 7,000 T. ovis eggs each, and those of the second group (5 lambs) and those of the third group (4 kids)--with 20,000 T. ovis eggs each. It was found that following infection the total activity of lactate dehydrogenase (LDH) rose, reaching its peak values on the 12th and 15th day. On the 12th day the strongly enhanced enzyme activity was due to the rise of LDH1, while on the 15th day the enhancement was associated with the rise of LDH5 that was characteristic of the skeletal muscles. In the period of forming the connective tissue capsule around the cysticerci the changes in the total activity and the isoenzyme spectrum were more slightly manifested. After the 30th day both the activity and the spectrum of LDH steadily came back to normal. With a C. ovis infection there was also a strongly expressed response on the part of hemopoietic organs, with a pronounced LDH3 activity.

Animals↗

PubMed1987

[Effect of a chromatographically purified bile secretion on the blood protein levels in hens].

The injection of chromatographically purified biliary fraction from broiler birds, rich in bile acids, led to a dependable drop of serum proteins in chickens. Treatment of the latter with a bile sample from swine, obtained in a similar way (the reaction for bile acids being negative) did not lead to essential changes in the content of plasma colloids. Results showed that bile acids were of definite importance as regards the blood level of proteins and the redistribution of proteins in the body with the individual species of animals.

Animals↗

PubMed1978

[Morphological changes in the liver of gamma-irradiated chick embryos and chickens].

The morphologic changes produced in the liver through irradiation at the rate of 1000 rad are characterized chiefly by a well expressed fatty dystrophia. At many sites there are pycnotic and lysed nuclei of the parenchymal cells. In the embryonic liver these changes are most strongly manifested in 12-day-old embryos. In contrast to the irradiated adult birds the embryonic liver presents no processes on necrosis after radiation treatment.

Animals↗

PubMed1977

[ATP and ATPase activity in the liver and brain cell fractions of gamma-irradiated chick embryos and newly hatched chicks].

Studied were the level of ADP and the adenosinetriphosphatase in nuclei, mitochondria, and microsomes taken from the brain and liver of singly gamma-irradiated at 1000 rd chick embryos and birds. As a result of the treatment of ADP content dropped, while the activity ADP rose. These changes were most strongly expressed in the nuclei, then in the mitochondria, and to a lesser extent-in the microsomes. Twelve-day chick embryos showed more markedly expressed radiosensitivity than newly hatched chicks. This embryonal state is characterized by intense growth, differentiation and metabolic processes in the liver, which substantiate not only the higher radiosensitivity of this age group but the more strongly expressed changes in the liver as compared with the brain.

Adenosine Triphosphatases↗

PubMed1977

[Treatment of rheumatoid arthritis with the immunosuppresive agent, prorezid].

Prorezid treatment was applied to 30 patients with rheumatoid arthritis. It was applied per os with a daily dose of 300 mg to 12 subjects; to 18-intravenous drop infusion with 5 per cent serum glucose--daily dose 400 mg. Oral administration total dose-7-8 g; infusion-10-12 g. Drop infusion administration proved to be more effective and especially the combination of the preparation with salycilates, pirazolon derivatives, minimal doses of corticosteroids and antibiotics. Favourable effect on articular syndrome was obtained in 20 patients (66.6%) about 2-3 and sometimes 4-6 weeks after the onset of the treatment. First the articular pain was attenuated, latter on--the morning stiffness (3-4 week), the movements in the joints involved were improved, the edema decreased towards the 4-6th weeks. A complete normalization of the laboratory indices was observed in none of those patients. In 10 of the patients (33.3%) no clinical improvement was attained in the course of the treatment. In four of them--the improvement developed 4-6 months later, with a longer drug administration. Prorezid preparation is with a low toxicity, with manifestation of transitory side effects in single patients--diarrhoea, mild leukopenia. Alopecia was not observed. Those properties make the drug suitable for application in patients with rheumatoid arthritis whose treatment with the rest applied drugs failed to give results.

Adult↗

PubMed1976

[Effect of ionizing radiation on the activity of liver acid phosphatase in chick embryos and chickens].

The treatment of chick embryos and chickens at 1000 rad leads to the decrease of the total activity and the increase of the free activity of the acid phosphatase in the liver. These changes are mostly manifested at the 72nd hour following irradiation. The electron-microscopic studies reveal secondary lysozomes (cytolyzomes) full of round or elongated structures of varying density. All changes are most strongly manifested in 12-day-old embryos, and are most weakly manifested in 20-day-old ones.

Acid Phosphatase↗

PubMed1976

[Effect of stimulating doses of ionizing radiation on the stability of the liver mitochondria of chick embryos and chicks].

Treatments at the rate of 3 rad of chick embryos and young birds have led to the stabilizing of the mitochondrial structures and to lowering the access of enzymes to their substrates. The free activity of malate dehydrogenase drops. Electron microscopic studies reveal that the number of mitochondria rises following irradiation with stimulating doses (3 rad). Mitochondrial cristae remain intact and the matrix presents higher electronic density.

Age Factors↗

PubMed1975

[Changes in the liver mitochondria due to gamma-ray irradiation of hen embryos and chickens].

Studied were the changes in the activity of the mitochondria-specific enzyme malatedehydrogenase (MDH) and the ATP content in the liver of chick embryos and chickens irradiated with 1000 rad. The total activity of MDH as well as the content of ATP dropped and the 'free' activity of MDH rose, but such was not the case of 20-day-old embryos. These changes were most pronounced in 12-day-old embryos. This showed that the changes in the mitochondria depend on the stage of embryonic development.

Adenosine Triphosphate↗

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