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B Topal

Publications and source records attributed to B Topal.

23 records · Page 2Linked to original sources
PubMed1997

Prognosis of gastric carcinoma with emphasis on lymph node status.

UNLABELLED: A retrospective study of surgical treatment for 123 patients with primary gastric carcinoma was made. Tumour-stage, presence of distant organ metastases, lymph node involvement, depth of wall-penetration and curative resection were the important prognostic criteria. Five-year survival rate was 22.8% in the whole series and 37.5% after curative (R0 M0) resection (p = 0.0029). Seventy-two patients (58.5%), i.e. 47 without (N0) and 25 with lymph node metastases (N1 + N2), underwent, R0-resection. The overall recurrence rate was significantly lower (4% vs. 36%; p = 0.004) and the 5-year survival rate higher (46% vs. 28%; p = 0.007) for the R0-N0-group than for the R0-N1 + N2-group. Distant organ metastases-related mortality was similar in these two groups of patients (51% vs. 60%; p = 0.7). CONCLUSION: The poor prognosis of gastric carcinoma indicates the need for improved surgical technique and/or adjuvant therapy, but the necessity for adjuvant therapy without having performed D2 gastrectomy does not seem founded.

Aged↗
PubMedDate not supplied

Reflections on three field lymphadenectomy in carcinoma of the esophagus and gastroesophageal junction.

BACKGROUND/AIMS: One of the most controversial questions in the surgical treatment of carcinoma of the esophagus and gastroesophageal junction (GEJ) is the extent of lymph node dissection, in particular the value of the cervical lymph node dissection (the so-called third field). METHODOLOGY: This study reflects a single institution's experience with this extensive lymphadenectomy, the technique of which is described in detail. RESULTS: Adding the third field to the lymph node dissection markedly improved accuracy of staging. Unforeseen involvement of lymph nodes in the neck was found in 30%. In T3N+ tumors of the GEJ, as much as 16.6% of positive lymph nodes were detected in the neck. Locoregional recurrence without distant metastasis was found in 6 patients (17.8%) out of a group of 37 patients with a minimum follow-up of 5 years. All 6 patients had stage IV disease because of distant lymph node metastasis (M+Ly). In 3 of these patients, locoregional recurrence occurred only after 3 years or more. In a subsequent series of 100 esophagectomies performed between 1992 and July 1993 no difference in outcome between radical versus standard resection was noticed for early stage I and II. However, there is a tendency towards a better estimated 5-year survival in favor of radical dissections (21%) versus standard resection (12%) in stage III and IV. CONCLUSIONS: Extensive three field lymphadenectomy can be safely performed without increasing hospital mortality (0%) and morbidity. Improved accuracy of staging, prolonged disease-free survival and potential increased cure rate are confirmed by our experience. Survival obtained with this technique has to be compared with survival obtained by other, multimodality treatment forms.

Adenocarcinoma↗
PubMedDate not supplied

Serological evaluation of 52 children immunized with the combined measles, mumps and rubella vaccine.

Fifty-two of 298 children vaccinated with the measles-mumps-rubella (MMR) vaccine at around the age of 16 months were evaluated for antibody titres against measles, mumps, and rubella. The seropositivity rates for measles, mumps, and rubella were 86%, 92%, and 98%, respectively. While the most prominent side effects were irritability (6.04%) and fever (4.69%), 83.55% of the vaccinated children showed no undesirable reaction to the vaccine. The MMR vaccine appeared to be immunogenic and nonreactogenic for the children in the study.

Antibodies, Viral↗