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Biomedical subjects

B Torrance

Publications and source records attributed to B Torrance.

33 records · Page 2Linked to original sources
PubMed1975

The value of the radio-isotope hepatogram in the jaundiced patient.

The distinction between 'medical' and 'surgical' jaundice is often difficult due to the lack of specificity of biochemical liver function tests, and the difficulty in assessing hepatocellular function and biliary tract patency in the jaundiced patient. We present a noninvasive isotopic technique which gives reliable information on these parameters, resulting in a high degree of accuracy in the classification of jaundice. 131I Rose Bengal, which is handled by the liver like bromsulphthalein, is administered intravenously and count rates during hepatic uptake and biliary excretion are recorded over the liver, biliary tract and duodenum using a gamma camera/computer system, into which is built an electronic light pen, so that particular areas of interest can be studied. Blood clearance of the iostope is simultaneously measured, and from these data the T 1/2 of uptake, the plasma retention and the excretion quotient are determined. The results of the first 80 examinations show that by qualitative assessment of the uptake and excretory phases of the 'hepatogram' and by determination of the T 1/2 and excretion quotient, jaundice has been classified with an 86 per cent accuracy in cases where the diagnosis is not apparent from clinical and biochemical data. The T 1/2 of uptake correlates well with bromsulphthalein retention in the non-jaundiced patient, and when applied to patients with obstructive jaundice enables the progress of hepatocellular impairment with time to be studied, and its recovery after relief of the obstruction. Preliminary results suggest that the technique may also have applications in the study of biliary tract dynamics in patients with post-cholecystectomy syndromes and relapsing acute pancreatitis.

Biliary Tract↗
PubMed1975

Observations of gastric mucosal blood flow using 99Tcm in rat and man.

The 99Tcm clearance technique is shown to be a useful method of assessing gastric function. It is easily carried out and is relatively non-toxic--the dose of isotope could be reduced to 100 muCi or less without sacrificing the accuracy of the investigation. Although the results are preliminary and the number of cases investigated so far is small, they suggest that the measurement of pertechnetate clearance is directly related to gastric mucosal blood flow; it is a useful parameter of gastric function and may well prove to be a more accurate discriminant in cases of peptic ulceration than the conventional measurement of gastric acid secretion.

Aminopyrine↗
PubMed1975

Is there an antral-body portal system in the stomach?

The direction of blood flow from the gastric mucosa of the antrum of the rat stomach has been studied using the isotope Rb86Cl. In a series of five experiments radioactivity has been shown to be transported via the blood stream from the antrum to the parietal cell mass without passing through the general circulation first. It is suggested that a 'portal' or direct transport system from antral mucosa to the body of the stomach exists.

Animals↗
PubMed1972

Three cases of spontaneous duodeno-colic fistula.

Three cases of duodeno-colic fistula are presented, where a communication was demonstrated between the anterior aspect of the third part of the duodenum and the transverse colon at the point of mesocolic attachment. At operation the fistulae were found to be some 6 to 9 cm in length, and histological examination showed a well marked muscular layer with an intact epithelium. In view of the absence of any explanatory pathology, an embryological basis is suggested as the likeliest explanation for their origin.

Colon↗