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Biomedical subjects

B Trbojević

Publications and source records attributed to B Trbojević.

6 recordsLinked to original sources
PubMed1991

[Thyroiditis].

We reviewed the results of the long term study of incidence, clinical characteristics, some etiological possibilities and pathogenetic mechanisms in inflammatory diseases of thyroid gland. Among persons who suffered of acute thyroiditis we presented the most frequent causes and prominent clinical characteristics in the course of the disease with special interest for predisposing factors. Contrary to the most frequent opinions, the number of cases with subacute (de Quervain) thyroiditis is so similar to the number of cases with Graves diseases. For these reason we concluded that subacute thyroiditis is important medical problem, in spite of its benignity. Even well known clinical characteristics and therapy of subacute thyroiditis, etiology and pathogenetic mechanisms are not well estimated. The group of chronical thyroiditis described as autoimmune thyroiditis, indicates on etiology of this heterogeneous group of thyroid diseases. Modern aspects of therapy are shown at the end of the study.

Humans↗
PubMed1991

[Determinants of susceptibility to the induction of autoimmune diabetes in inbred strains of rats].

Interleukin 2 (IL 2) proved to be important for the generation of autoreactive T cells in the pathogenesis of different autoimmune disorders, including diabetes. Also, we have previously shown that lymphoid cells obtained from inbred strains of rats Dark August (DA) and Albino Oxford (AO) exhibited a genetically determined difference in their ability to produce IL 2. In this study, in DA and AO rats, we analysed the susceptibility to the induction of autoimmune diabetes with multiple subdiabetogenic doses of alloxan. Rats were injected i.v. with 25 mg/kg b.w. of alloxan in 5 consecutive days. All DA rats developed moderate and persistent hyperglycaemia 15 days after the induction. In contrast, AO rats failed to develop the disease after the same regimen of induction. When the induction was made in (AO x DA)F1 rats, all of them developed the disease similar to the susceptible parental DA strain. However, the onset was delayed (the 40th day after the induction) and the glycaemia was constantly lower than in DA rats. Our results indicate that the difference in the response to the induction of autoimmune diabetes between susceptible DA strain, being high IL 2 producer, and resistant AO strain, being low IL 2 producer, is genetically determined. The results also suggest that this control could involve the gene determining the level of IL 2 production in DA and AO rats, thus signifying that the susceptibility to the induction of this form of autoimmune diabetes could be related to the level of IL 2 activity.

Alloxan↗
PubMedDate not supplied

[Diagnosis and monitoring of patients with type IIa multiple endocrine neoplasms].

Syndrome of multiple endocrine neoplasia, type IIa, is a rare disturbance made by medullar carcinoma of the thyroid gland, pheochromacytoma and hyperparathyroidism. The article deals with three patients with multiple endocrine neoplasia, type IIa, with special emphasis to detection of the disease in time and treatment of the patients in the early phase of the illness. This is a hereditary autosomal dominant disturbance. Tests performed among members of family with high risk factors of the disease are of great importance. In this way early diagnosis is possible, and consequently, prevention of fatal issue due to pheochromocytoma and medullar carcinoma.

Adult↗
PubMedDate not supplied

Postprandial response of serum cationic trypsin-like immunoreactivity in insulin-dependent diabetes mellitus.

Conflicting reports exist on the postprandial response of serum cationic trypsin like immunoreactivity (SCTLI). The purpose of the current study was to examine the postprandial response of SCTLI in healthy persons and in insulin dependent diabetes mellitus (IDDM) patients and relate this to C-peptide secretion. The study was performed on six healthy males 25-40 years old and in nine male IDDM patients 25-38 years old. To all the patients after an overnight fast was given a standardized breakfast. Blood samples were obtained through a butterfly needle inserted into the antecubital vein at 0, 30, 60 and 120 minutes. Radioimmunoassays were performed using commercially available kits: for SCTLI CIS-SORIN and for C-peptide BIODATA. In healthy persons there was a significant rise of SCTLI concentration at 30 minutes, and C-peptide at 30 and 60 minutes. IDDM patients showed lower basal levels of SCTLI and C-peptide, without any significant changes of SCTLI and C-peptide during the test. We concluded that trypsin appearance in serum closely correlates with endocrine pancreatic function.

Adult↗