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Biomedical subjects

B Ursing

Publications and source records attributed to B Ursing.

At least 37 records · Page 2Linked to original sources
PubMed1980

Lack of evidence for an association between infection with Chlamydia trachomatis and Crohn's disease, as indicated by micro-immunofluorescence antibody tests.

A significant difference has recently been reported in the occurrence of serum antibodies to the lymphogranuloma venereum (LGV) immunotypes of Chlamydia trachomatis in patients with Crohn's disease and controls. In the present study, sera from 107 patients with Crohn's disease, 33 males and 74 females, were tested for antibodies to C. trachomatis by an indirect immunofluorescence test, using two pools of antigens. These pools contained antigens to immunotypes TRIC D-K and LGV 1-3, respectively. None of the patients had IgM antibodies to the organism. IgG antibodies occurred significantly more often in the female than in male patients. No correlation could be demonstrated between activity and duration of Crohn's disease and the results of the antibody tests. For comparison, the sera of 50 puerperal women were studied. No difference in the occurence of IgG antibodies was found between patients and controls, neither when using the two pools of antigen, thus indicating that the antibodies detected had probably been induced by TRIC rather than LGV organisms. To conclude, the study did not indicate an association between Crohn's disease and infection with C. trachomatis.

Antibodies, Bacterial↗
PubMed1980

Chronic meningitis in patients with dental infections.

4 patients with a history of initial fever 2--4 weeks passing on to fever peaks every 3rd to 6th day with afebrile intervals repeating for months are presented. Three of them had dental infectious foci mainly in maxillar teeth and 1 patient was treated by a dentist 1 month before onset. None showed meningism or clinical signs of encephalitis. Extensive investigations resulted only in findings from the central nervous system. The EEG was slightly pathological in all cases and papilloedema was found in 2 cases. In the cerebrospinal fluid (CSF) a pleocytosis extending over months, transient presence of plasma cells and increased proteins in the gamma region on agar electrophoresis was found. In 1 case antigen from Streptococcus milleri, a commensal of the mouth flora at times isolated from infectious dental foci, was detected in CSF by counterimmunoelectrophoresis 6 weeks after onset of the disease. Treatment with penicillin had no effect on the fever. Three patients received antiphlogistic drugs with benefit and their dental foci were treated by a dentist.

Adult↗
PubMed1979

Treatment of anaerobic infections with metronidazole.

Metronidazole (Flagl), a compound widely used in man with minimal side-effects, has been used in the treatment of anaerobic infections caused by Bacteroides fragilis and other Bacteroides species. Seven patients were treated and all were restored to full health. Four of them did not respond to lincomycin or clindamycin which so far have been the drugs of choice against anaerobic infections. The reasons for the good results during metronidazole therapy such as the good penetration through the blood/brain barrier and into abscess cavities are discussed.

Adult↗
PubMed1977

Bioavailability of metronidazole in fasting and non-fasting healthy subjects and in patients with Crohn's disease.

The possible influence of food intake on the bioavailability of metronidazole was examined in ten health volunteers by administration of a single dose of metronidazole on an empty stomach, and with a standardized breakfast. Food intake did not significantly alter the bioavailability of metronidazole. The interindividual variation in bioavailability appeared to be slight. In nine patients with Crohn's disease, the absorption of metronidazole appeared to be reduced and to be more variable than in healthy subjects. In both groups there was a clear relationship between the amount absorbed and dose/kg body weight. Thus, from the pharmacokinetic point of view, metronidazole can safely be given either with or between meals. The dose should be related to body weight.

Adult↗
PubMed1976

Enterovirus infections in acute pancreatitis - a possible etiological connection.

All patients admitted with a preliminary diagnosis of acute pancreatitis during a one-year period were subjected to virus investigations. 142 patients were included in the study and of these 91 were found to have acute pancreatitis. Evidence of enteroviral infection was found in 18 of the 91 patients (19.8 per cent). From 17 of the 18 patients enterovirus was isolated from feces or urine, and in one a significant titer rise (CF-test) against Coxsackie virus B5 was found. A significant titer rise of antibodies against the virus type isolated could be demonstrated in 7 of the 17 patients. Thus in 8 cases there was obvious evidence of an acute enteroviral infection during the episode of acute pancreatitis. The etiological agents in these cases were Coxsackie viruses B2, B3, and B5, and ECHO-viruses 6, 11, 22, and 30.

Acute Disease↗
PubMed1975

Metronidazole for Crohn's disease.

Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole. Four of them improved after 2-4 weeks' treatment. In three of them corticosteroids and sulphasalazine could be withdrawn. One patient did not improve until 4 months of metronidazole treatment had passed and corticosteroids were reintroduced. In three patients metronidazole was discontinued after 4-6 months of treatment. Two of them had no signs or symptoms of relapse 3 and 6 months later. The third patient is free from symptoms but laboratory data indicate disease activity.

Adult↗
PubMed1975

Persistent cerebellar symptoms after infection with Mycoplasma pneumoniae.

Mycoplasma pneumoniae infection in a 47-year-old man is reported. Symptoms of upper respiratory tract infection were followed by pneumonia and meningoencephalitis. In contrast to published cases with neurological manifestations of infection with M. pneumoniae, the patient was disabled by persistent cerebellar symptoms with generalized ataxia and atactic dysarthria. Some possible pathogenic mechanisms of the neurological manifestations of infection with M. pneumoniae are considered.

Antibodies, Bacterial↗