Metastatic adenocarcinoma of the prostate manifested as a sellar tumor.
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Adenocarcinoma↗
Biomedical subjects
B V Reddy
Publications and source records attributed to B V Reddy.
Impact of chronic phosalone toxicity on Bohr factor and oxygen equilibrium curves of rat.
The multiple sublethal doses of phosalone induced changes in haemodynamics, maximum absorption spectra, oxygen equilibrium curves (OEC), half saturation tension (P50), degree of interaction (n), pH of blood, Bohr factor and circulatory gases of blood in rat, Rattus norvegicus. The results have obviously shown that increase the activation of pyridoxal phosphate, shift of OEC to right and decrease in the affinity of haemoglobin for oxygen at tissue level.
Animals↗
Effect of chronic insecticide, phosalone, toxicity on haem synthesis and blood gas composition in the rat.
The influence of multiple sublethal concentrations of phosalone on whole animal and kidney oxygen consumption, haem synthesis and blood gases of rat, were carried out over a 90 day dosed period. The results indicate the existence of hypoventilation and a hypoxic condition in the animals which lead to the disruption of neuromuscular transmission in respiratory muscles and increase of erythropoiesis and haemoglobin synthesis. The changes were most pronounced when animals were exposed for the 90 day dosed period.
Animals↗
Impact of chronic phosalone toxicity on erythropoietic activity of fish, Oreochromis mossambicus.
Effect of multiple sublethal concentrations of Phosalone on whole animal and kidney oxygen consumption, haematological indices and serum enzymes of freshwater fish, Oreochromis mossambicus, were carried out over a 90 day exposure period. Significant changes were observed which have been indicating that the presence of hypoxic condition in the biosystem, gradual increase in the rate of synthesis of haemoglobin and disruption of liver function during the toxicity of phosalone.
Animals↗
Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence.
Statistical analysis of 12 unstable and 32 stable proteins revealed that there are certain dipeptides, the occurrence of which is significantly different in the unstable proteins compared with those in the stable ones. Based on the impact of these dipeptides on the unstable proteins over the stable ones, a weight value of instability is assigned to each of the dipeptides. For a given protein the summation of these weight values normalized to the length of its sequence helps to distinguish between unstable and stable proteins. Results suggest that the in vivo instability of proteins is possibly determined by the order of certain amino acids in its sequence. An attempt is made to correlate metabolic stability of proteins with features of their primary sequence where weight values of instability for a protein of known sequence could thus be used as an index for predicting its stability characteristics.
Amino Acid Sequence↗
Testosterone response in arginine vasopressin desensitized immature rat testis.
Direct injection of arginine vasopressin into immature rat testis inhibited basal testosterone synthesis. Simultaneous injection of arginine vasopressin with luteinizing hormone, norepinephrine or cholera toxin inhibited these agonists - induced testosterone response. In arginine vasopressin - desensitized testis, cAMP response to luteinizing hormone, norepinephrine and cholera toxin was not disturbed. However, testosterone response to luteinizing hormone, norepinephrine or cholera toxin was drastically reduced in arginine vasopressin-desensitized testis. This shows that the increased cAMP generated by luteinizing hormone, norepinephrine or cholera toxin in arginine vasopressin desensitized testis did not cause increase in steroidogenesis. This could be due to a lesion in steroidogenic pathway beyond cAMP generation caused by arginine vasopressin.
Animals↗
Effects of vanadyl sulphate on ornithine decarboxylase and progesterone levels in the ovary of rat.
The effects of vanadyl sulphate in vitro on the levels of ODC activity and progesterone synthesis in ovaries were studied. The levels of ODC in the ovaries were stimulated with high concentration of vanadyl sulphate and at low concentrations there was no change in the levels of ODC activity. On the contrary progesterone levels were stimulated with low concentrations of vanadyl sulphate and were inhibited at higher concentrations. Vanadyl sulphate showed additional stimulation of ODC activity, when it was added with hCG and caused inhibition of hCG induced progesterone biosynthesis. These results show that the effects of vanadyl sulphate on ODC and progesterone are different.
Animals↗
Desensitization of immature rat testicular ornithine decarboxylase to arginine vasopressin.
Prior exposure of immature rat testis to arginine vasopressin caused the testis refractory at 24 h in terms of ornithine decarboxylase activity. Arginine vasopressin caused desensitization both in Leydig cells and seminiferous tubules. Arginine vasopressin induced desensitization was found to be both time and dose-dependent. Arginine vasopressin desensitized testis was refractory to luteinizing hormone, follicle stimulating hormone, norepinephrine, dibutyryl cAMP, phorbol-myristate acetate and cholera toxin at 24 h. Arginine vasopressin desensitized testis showed recovery of response to norepinephrine at 48 h after the first injection. On the contrary arginine vasopressin could stimulate ornithine decarboxylase in luteinizing hormone desensitized testis. These results indicate that in arginine vasopressin desensitized testis the block is at post cAMP step which is common to both cAMP dependent and protein kinase C-diacylglycerol system in stimulating testicular ornithine decarboxylase.
Animals↗
Contextual constraints on codon pair usage: structural and biological implications.
Complementary DNA sequence data of 278 protein coding genes from prokaryotic systems have been analysed at the level of near neighbour codon pairs. Our analysis points out that constraints exist even at the level of near neighbour codon pairs. These constraints are in addition to those which arise due to relative levels of tRNA. Codon pairs, which in the data base have different occurrence values from their expected values, neither have common secondary structure nor do have better stabilization due to high base stacking. Our study points out that there are strong interaction between constituent codons in these codon pairs. These strongly interacting codon pairs, we suggest, are involved in the formation of three dimensional structural elements of cDNA/mRNA and interact with ribosome and thus modulate translation.
Base Sequence↗
Stimulation of testicular ornithine decarboxylase activity by arginine vasopressin.
Intratesticular injection with arginine vasopressin caused stimulation of ornithine decarboxylase activity in the testes of immature rats. The increase in ornithine decarboxylase activity in response to arginine vasopressin was dose and time dependent. Maximal stimulation of ornithine decarboxylase activity occurred at 2 h after injection with 0.1 micrograms of arginine vasopressin. It was observed that stimulation of ornithine decarboxylase activity occurred in seminiferous tubules and in Leydig cells of the testis in response to arginine vasopressin.
Animals↗
A method to locate protein coding sequences in DNA of prokaryotic systems.
cDNA sequence data from E. coli phages, for which complete genome sequences are known, have been analysed, From this analysis thirteen triplets have been identified as markers to distinguish protein-coding frames from fortuitous open reading frames. The region of -18 to +18 nucleotides around ATG/GTG, has been analysed and used to identify initiator codons from internal ATG/GTG. With the aid of criteria defined above a method has been developed to locate protein coding sequences by a combination of 'gene search by signal' and 'gene search by content' approaches. Application of this method to prokaryotic systems including those which were not part of our data base indicates that it is quite accurate and general in nature.
Bacterial Proteins↗
Serum magnesium levels in schizophrenia.
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Acute Disease↗