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Biomedical subjects

B V Zhuravlev

Publications and source records attributed to B V Zhuravlev.

29 records · Page 2Linked to original sources
PubMedDate not supplied

[Effect of cholecystokinin octapeptide on brain monoamine levels during feeding and drinking motivational excitation].

The paper presents studies of the influence of octapeptide cholecystokinin (ChCK-8) on the level of dofamine, noradrenaline and serotonine in the hypothalamus, septum, amygdala, striatum and mesencephalon of the rats brain during 24-, 48- and 96-hour alimentary and water deprivation. A change of catecholamines content under the influence of ChCK-8 was observed for the most part in conditions of thirst and only in the hypothalamus. ChCK-8 action in conditions of water deprivation was selective and directed mainly to the restoration of the changes in transmitter's level. ChCK-8 did not have a significant influence on the level of the brain monoamines during hunger. It may be assumed, that "satiation" hormone ChCK-8 is to a great extent connected with the mechanisms of reinforcement, and its "satiating" effect would appear at catecholamines' level in the process of satisfying of corresponding need.

Animals↗
PubMedDate not supplied

[4-channel electroencephalographic amplifier with integrated microcircuits].

To conduct electroencephalographic investigations of stationary and moving objects a small-sized 4-channel amplifier built with integrated microcircuits has been developed. Each channel includes a pre-amplifier, main amplifier, calibrator, high and low frequency filters and a power pack. The adoption of integrated microcircuits enables it to locate the pre-amplifiers directly on the object of investigations. The device is highly sensitive and secures a greater degree of noise-protection.

Amplifiers, Electronic↗
PubMedDate not supplied

[Electrical activity of the subcortical structures and the cerebral cortex in hunger].

It has been demonstrated in chronic experiments on dogs with electrodes implanted into different brain areas and with a gastric fistula according to Basov that there is a consistent variation in the encephalographic picture of electrical activity of subcortical structures and brain cortex depending on periodic activity of the gastrointestinal tract. These changes have been discovered to correlate with blood glucose content. The reported data have been confirmed concerning the release of nutritive substances from the depot at the end of an active period of gastric motility. This is attested to by an increase in blood glucose concentration and appearance of high-amplitude slow fluctuations in subcortical structures and brain cortex. Exogenous cholecystokinin-pancreozymin has been demonstrated to have a characteristic effect on electrical activity of brain structures under study, which might serve one more evidence in favour of the involvement of this hormone in periodic activity of the gastrointestinal tract.

Animals↗
PubMedDate not supplied

[Analysis of the spike activity of neurons of the orbital cortex of rabbits during feeding behavior].

Computer analysis of statistical characteristics (mean interspike interval, mean frequency of discharges, standard deviation, variation coefficient, coefficients of serial correlation and histograms of interspike intervals duration) of spike activity of 31 neurones in the orbital cortex recorded in eleven experiments on six unrestrained rabbits reveals a specific reflection of the main stages of the animals' alimentary purposive behaviour.

Action Potentials↗
PubMedDate not supplied

[The effect of the immunomodulator neurotropin on the learning of active defensive behavior by rats].

Rats were intraperitoneally injected with neurotropin (NSP), a substrate extracted from the inflammatory dermis of rabbits inoculated with Vaccine virus. Active avoidance behaviour of rats was studied. After NSP administration rats demonstrated higher levels of conditioning and true responses compared with control. In NSP-treated rats relationship between the time of beginning of intersignal run during learning and success of the avoidance trial differed from that in the control group. The results suggest that neurotropin administration activates the retrieval processes and leads to stronger consolidation of avoidance behaviour.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Food-acquisition and avoidance behaviors: the role of immunomodulators in their systemic organization].

The experimental data concerning some aspects of neuroimmunology were analysed. The problems of likeness between immune and nervous systems (origin, functions, common substances, etc.) and particularly the participation of immunomodulators in the mechanisms of neural memory are under discussion. It was shown that administration of immunomodulator neurotropin (NSP) results in more steady consolidation and retention of feeding and avoidance behavior, and some neurophysiological mechanisms of that phenomena were revealed. Among them were the reorganization of neuronal interspike patterns in cortex and hippocampus; increasing the levels of vegetative (heart rate, respiration) and behavior parameters of learning during conditioning. Whole this complex of changes was retrieved during intersignal periods. The results suggest that one of the mechanisms of immunomodulators action on the learning and memory is the activation of reverberation processes in brain.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Systemic analysis of neuroimmune mechanisms of memory].

Administration of IL-1 beta and 125-129 fragment of alpha 2-interferon improved learning and retention of active avoidance behaviour in memory in rats. It also improved the correlation between intersignal runs and success of the avoidance behaviour learning. The data obtained suggest that an activation of the intersignal retention process is one of the mechanisms of the immunomodulators effect on learning and memory.

Adjuvants, Immunologic↗