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Biomedical subjects

B Varga

Publications and source records attributed to B Varga.

12 recordsLinked to original sources
PubMed1979

Stimulation of the alpha-and beta-adrenergic receptors in human ovarian vasculature in vitro.

The effect of fenoterol and norepinephrine was studied on the vascular resistance of in vitro perfused human ovary. It was found that the beta-adrenergic stimulant fenoterol causes vasodilatation, whereas the alpha-adrenergic stimulant norepinephrine elicits vasoconstriction in the arterial vascular bed of the ovary showing the role of adrenergic mechanism in the regulation of ovarian blood flow. It was supposed that therapeutical administration of beta-mimetic drugs leads to the elevation of ovarian blood flow, which may have special importance in the case of corpus luteum insufficiency.

Adult↗
PubMed1979

Inhibition of the stimulatory effect of ACTH on adrenal and ovarian blood flow by indomethacin in the dog.

In anoestrous dogs heated thermocouples were inserted into one of the adrenals and ovaries. The basal adrenal and ovarian blood flow was recorded and enhanced by 1.2, 2.5 or 5.0 micrograms/kg of intravenous ACTH before and after the intravenous administration of 20 or 50 mg/kg of indomethacin. Indomethacin, depending on the dose and on the time elapsing after its administration inhibited the enhancing effect of ACTH on adrenal and ovarian blood flow. Since indomethacin is a specific inhibitor of prostaglandin synthesis it has been suggested that prostaglandins act as mediators in the vasodilatation elicited by ACTH in the canine adrenal and ovary.

Adrenal Glands↗
PubMed1977

Effects of prostaglandins on ovarian blood flow in the bitch.

Oestrus and anoestrous mongrel dogs were anaesthetized with chloralose-urethane. In one group, the ovaries were isolated in situ and the effects of a 15-min infusion of PGF-2alpha or PGE-2 on perfusion pressure were measured. In the other group, heated thermocouples were introduced into the stroma of each ovary to measure the changes of local blood flow in response to PGF-2 alpha and PGE-2 infused into the ovarian bursa for 15 min. Intra-arterial infusion of 25.50, 100 or 200 ng PGF-2alpha/kg/min did not affect perfusion pressure; PGE-2 doses of 3.1, 6.2, 12.5 or 25 ng/kg/min caused reductions in proportion to the dose. All doses of PGE-2alpha (50.0, 100 or 200 ng/kg/min) or PGE-2 (25, 50 or 100 ng/kg/min) increased blood flow in the ovarian stroma in proportion to the dose when administered by infusion into the ovarian bursa. There were no differences in the results from oestrous and anoestrous dogs. It is concluded that PGF-2alpha changes intraovarian blood distribution without interfering with the total blood flow while PGE-2 increases both the total and local ovarian blood flow.

Animals↗
PubMed1977

Humoral influences on local blood flow and external secretion of the resting dog pancreas.

Graded doses of glucagon (2--8 microgram/kg b. w.), prostaglandin E1 (PGE1) (125--1000 ng/kg b. w.), caerulein (1--32 ng/kg b. w.) and a synthetic C-terminal octapeptide of cholecystokinin-pancreozymin (CCK--PZ) 50--400 ng/kg b. w.) were infused into the superior pancreatioduodenal artery in chloralose-anaesthetized dogs to study the effect on blood flow and external secretion of the resting pancreas. Local blood flow was measured by a heated thermocouple inserted into pancreatic tissue supplied by the superior pancreaticoduodenal artery. Blood flow through this artery was measured by electromagnetic flowmeter. Juice was collected from the cannulated main pancreatic duct. Each of the four agents significantly increased pancreatic blood flow. There was a linear correlation between the doses and the blood flow responses. Caerulein and the synthetic C-terminal octapeptide of CCK--PZ increased the amount of secreted juice from the resting pancreas. The C-terminal octapeptide of CCK--PZ elevated the protein concentration of the secreted juice in proportion to the dose. Glucagon and PGE1 did not influence the amount of secreted juice from the resting gland.

Animals↗
PubMed1976

ECG changes in benzene, toluene and xylene poisoned rats.

Electrical activity of the heart was studied in acute, subacute and chronic benzene, toluene and xylene poisoning by means of NEK-2 type apparatus in CFY male rats. In the early period of acute intoxication benzene and its methyl derivatives, injected either intraperitoneally or subcutaneously or administered by inhalation did not cause changes in the ECG. Intravenously injected toluene induced a rapid and permanent decrease in blood pressure, in higher doses respiratory paralysis. In acute inhalation toluene and xylene poisoning the anesthesia was followed by respiratory paralysis, bradyarrhythmia and asystole, while inhalation of benzene induced respiratory paralysis followed by ventricular fibrillation. Subacute poisoning with benzene, toluene and xylene caused disorders in repolarization and arrhythmia. The degree, incidence and development of these phenomena depended on the dose and the duration of exposure. The effect of benzene influencing ECG was appreciably more intensive than that of toluene or xylene. Owing to the high number of spontaneous ECG changes due to ageing, it is difficult to evaluate the effect of chronic exposure to the agents under investigation.

Acute Disease↗
PubMed1976

Competitive protein binding assay of oestradiol-17 beta and oestrone using uterine cytosol prepared from HCG-treated rabbits.

Uterine cytosol was prepared from rabbits after treatment with human chorionic gonadotrophin (HCG) and used for the determination of oestradiol-17 beta and oestrone by competitive protein binding (CPB) assay. The so obtained uterine cytosol gave higher percentage of binding and proved to be more stable when stored at --20 degrees C than cytosol obtained from the pregnant uterus.

Animals↗
PubMed1975

Syndrome of the rectus abdominis muscle: A peripheral neurological condition causing abdominal diagnostic problems.

Four cases of a painful abdominal syndrome are presented, the pain occurring in the distribution of the medial cutaneous branch of the 7th--12th intercostal nerves. The diagnosis presents difficulties because of severe abdominal pain. In 2 cases the clinical observations were corroborated by EMG findings. The symptoms, physical manifestations, mode of development and therapy are described. The term proposed for the condition is: Syndrome of the Rectus Abdominis Muscle.

Abdomen, Acute↗
PubMed1975

Effects of ACTH on the uterine weight response to HCG in mice.

The effects of ACTH and dexamethasone on the uterine weight of immature mice treated with HCG or oestradiol-17 beta were studied. The animals were treated daily for 3 days and wet and dry uterine weights were measured on the 4th day. Low doses of ACTH (1-25 mug/day) raised the sensitivity of the uterine weight response to threshold doses of HCG (0-05 to 0-1 i.u.). By increasing the doses of ACTH or HCG, the stimulation gradually turned into inhibition. By itself, ACTH was ineffective and it had no influence on the increase in uterine weight induced by oestradiol-17 beta. Dexamethasone failed to stimulate the effect of HCG.

Adrenocorticotropic Hormone↗
PubMed1975

Role of prostaglandin E2 in the stimulatory effect of ACTH on ovarian blood flow.

It has been studied in dogs anaesthetized with chloralose-urethane whether Prostaglandin E2(PGE2) might act as a mediator of the stimulatory effect of ACTH on ovarian blood flow. Without any damage to the ovarian vessels, a heated thermocouple was inserted into the stroma of the ovaries and local blood flow was recorded continuously. Similarly to ACTH, PGE2 (100 ng/kg/min) infused into the ovarian bursa increased local blood flow. The ovaries were isolated in situ and perfused by a peristaltic pump from the femoral artery. Synthetic ACTH or PGE2 was infused into the ovarian artery for 15 min and perfusion pressure was measured. Both ACTH (12.5--25.0--50.0--100.0 ng/kg/min) and PGE2 (3912--6.25--12.50--25.00 ng/kg/min) reduced perfusion pressure, caused vasodilatation. There was a significant linear correlation between the degree of vasodilatation and the logarithm of the doses. If the doses of the two agents are expressed in terms of mols, the effect of both agents can be characterized by a common equation. Fifty--200 mug/kg indomethacin inhibited the effect of ACTH but increased the effect of PGE2. It is suggested that in dogs ACTH exerts its ovarian blood flow stimulatory effect by releasing PGE2 or some similar agent(s).

Adrenocorticotropic Hormone↗