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Biomedical subjects

B Vidić

Publications and source records attributed to B Vidić.

At least 19 recordsLinked to original sources
PubMed1994

[Zoonoses in Vojvodina. III. Results of a seroepidemiologic study of leptospirosis in Vojvodina].

2697 persons professionally exposed to leptospira working in contaminated waters and grounds or due to contact with infected animals or their products were seroepidemiologically examined. It was established that the presence of leptospirosis in certain categories of examined persons is three to more than ten times higher in relation with it's presence in the control groups. The most frequent serotype was Leptospira pomona. None of the seropositive persons gave data about having leptospirous infection which might be the consequence of asymptomatic infection or unidentified and not registering of the clinically manifested diseases.

Adolescent↗
PubMed1992

Scanning tunneling microscopic (STM) analysis of the phospholipid bilayer surface characteristics in the P beta phase. Secondary ripples.

Previous investigations have elaborated on the necessity for dimyristoylphosphatidylcholine (DMPC) molecules to conform in a ripple phase at the temperature intermediate between the transition and pretransition in order to protect the hydrophilic-hydrophobic polarity of the bilayer. Present observations, in addition to the asymmetric P beta phase of 11.1 +/- 1.3 nm wave-length, demonstrate orthogonal corrugations perpendicular to the main wave direction. Whether this is a prerequisite for maintaining the molecular order-disorder balance at such specific temperature, or it results from yet unknown source is unclear at present.

Dimyristoylphosphatidylcholine↗
PubMed1989

Differentiation of interstitial cells and stromal proteins in the secondary septum of early postnatal rat: effect of maternal chronic exposure to whole cigarette smoke.

The intention of this investigation was to ascertain the effect of maternal exposure to cigarette smoke on the early postnatal morphogenesis of pulmonary interstitium in offspring. Female rats were chronically exposed to whole cigarette smoke. Offspring of these and control animals were sacrificed at postnatal day 15, and their tissues were prepared for quantitative and qualitative analyses. Results indicate a diminished quantitative representation of parenchymal tissue (P less than 0.01) and a slower pace of secondary septal growth (P less than 0.07) in the experimental lung. Furthermore, a greater cellular volume density (P less than 0.0002) and, inversely, a lesser quantitative representation of extracellular matrix (P less than 0.0002) was ascertained for the experimental septal interstitium. There was proportionately less of elastin substances (P less than 0.009), collagen together with basal laminae (P less than 0.0008), and nonfibrillar, amorphous matrix (P less than 0.02) in the experimental extracellular stroma. Fibrillar collagen and nonfibrillar matrix were represented quantitatively 6.3 times more in the experimental extracellular interstitium than elastin, whereas that ratio for the control tissue was only 4.2. Most experimental interstitial cells (80%) contained numerous lipid globules, which, in contrast, were only occasionally present in control cells (7.3%). Experimental cells, consequently, possessed a larger cross-sectional diameter and a smaller nucleus-to-cytoplasm volume ratio than control cells. These divergent developmental patterns are possibly suggestive of a delayed differentiation of interstitial cells and a modified production to degradation balance of stromal proteins in offspring of animals chronically exposed to whole cigarette smoke.

Animals↗
PubMed1989

Effect of maternal exposure to smoke on gas diffusion capacity in neonatal rat.

Offspring of control and experimental (chronically exposed to whole cigarette smoke) rats were sacrificed on 15th postnatal day. Pulmonary tissues were processed for quantitative electron microscopic analyses. Arithmetic and harmonic mean thicknesses were directly measured and diffusion capacity was derived for separate layers (tissue, plasma, erythrocyte) and the entire lung. Experimental offspring showed a greater volume density of interstitium in parenchyma (P less than 0.04), arithmetic (P less than 0.05) and harmonic (P less than 0.009) mean thicknesses. Diffusion capacities for lungs of both animal groups, however, were similar (0.00543 and 0.0054 cm3 O2.min-1.mm Hg-1.g body weight-1 for control and experimental lungs respectively). Experimental tissue appeared better adapted for optimal exchange of gases (P less than 0.05), as indicated by corrugation index (ratio between arithmetic and harmonic mean thicknesses) than for the control counterpart. In spite of induced alterations in several developmental processes by a presently used experimental procedure, tissue capacity for transport of gases was not significantly changed in either the alveolo-capillary membrane or the entire lung.

Animals↗
PubMed1987

The embryogenesis and anatomy of Waldeyer's ring.

The developmental history of the embryonic germ disk is briefly traced through the bilaminar, trilaminar, and bodyfold stages with emphasis on the pharyngeal arches, pouches, and clefts. This is followed by a discussion of the genesis and adult anatomy of the tonsillar tissues.

Adenoids↗
PubMed1983

Morphometric analysis of the remodeling of the rat pulmonary epithelium during early postnatal development.

In the rat lung the alveoli are formed in the early postnatal period. Within 3 weeks the alveolar surface area increases more than five-fold and the saccular lung reaches its mature structure. In order to analyse the changes in the compartments of the parenchymal tissue, the lungs of three animals per group aged 4, 13, and 21 days, respectively, were investigated by means of electron microscopic morphometry. Whereas the capillarisation of the interalveolar septa almost doubled in the period investigated, the endothelium and alveolar epithelium increased their share of the septal tissue at the expense of the interstitial compartment. The cellularity of the interstitium decreased markedly with age, the ratio of cells to interstitial spaces falling from 5.1 to 1.7. Within the epithelium, the type II cell population increased its mass almost six times, representing 58% of the alveolar epithelial volume at 3 weeks. Accordingly, the portion of alveolar surface area covered by type II cells was highest on day 21, with 9% versus 5.6% on day 4, and around 3% in a normal adult lung. The observed quantitative structural changes are discussed in the light of the functional demands of the organ: the need for an expanding alveolar surface area to be covered by a thin epithelial lining layer, the maintenance of a thin air-blood barrier, and a quantitatively adapted secretion of alveolar surfactant.

Animals↗
PubMed1978

Estrogen and tracheal secretion: the effect of estrogen on the epithelial secretory cells of the rat trachea.

Epithelial secretory cells of the tracheal mucosa obtained from ovariectomized control and ovariectomized estrogen-treated rats were studied morphologically by scanning and transmission electron microscopy and by the combined periodic acid Schiff (PAS) and alcian blue (AB) staining method. A significant decrease was observed in the number of large PAS-reactive secretory cells following estrogen treatment. Concomitantly the number of the Mixed+ cells containing both weakly acid and neutral glycoproteins was found to increase significantly. A majority of the observed secretory cells exhibited either an apical protrusion loaded with secretory granules, extending to a maximum distance of 7.9 micrometer into the tracheal lumen or an apical indentation devoid of mature secretory granules, descending to 5.6 micrometer below the luminal surface. The frequency of cells exhibiting an apical indentation was significantly greater in estrogen-treated animals than in controls. The present findings indicate that estrogen treatment of ovariectomized rats results in: 1) an increase in the synthesis of weakly acid glycoprotein within tracheal secretory cells; 2) a concomitant decrease in the frequency of secretory cells containing neutral glycoprotein; and 3) a general increase in the secretion by the tracheal cells.

Animals↗
PubMed1976

Ultrastructure of the secretory cells of the submucosal glands in the human maxillary sinus.

Tissue samples obtained from the lateral wall of the maxillary sinuses of five patients were examined by light microscopical, histochemical, and ultrastructural techniques. Submucosal glands were tubulo-alveolar mixed glands. The acini consisted of either all serous or all mucous cells, or a mixture of both. Serous granules were stained by toluidine blue, or by hematoxylin and eosin (H and E), but showed little or no reaction with periodic acid-Schiff (PAS) or Alcian blue. Mucous granules were pale in toluidine blue or H and E preparations, and consisted primarly of acid mucosubstances, as demonstrated by their staining reaction with PAS and Alcian blue. At the electron microscope level, the serous granules were either homogeneously dense, or showed a substructure consisting of at least two layers of distincly different electron-opacity. Typical mucous droplets consisted of a fibrillar network dispersed in a translucent matrix. A second secretory product was present in the mucous cells in the form of elongated, membrane-bounded structures containing numerous parallel filaments, which measured about 55 A in diameter. The mucous droplets and the filamentous bodies appear to arise from the opposite faces of the Golgi complex in the mucous cells. The filamentous bodies showed a pronounced tendency to fuse with the mucous droplets. All acini were surrounded by a well-defined myoepithelial layer and contained intercellular nerve terminals.

Cytoplasmic Granules↗