[Surgery of the cervical spine using a mixed approach].
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Biomedical subjects
Publications and source records attributed to B Vlahovitch.
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Intra operative Doppler has been already used especially during cerebral vascular malformations surgery. The systematic practice of this method, in 15 cases, for the blood flow study of the sub millimetric cortical vessels is helpful, very simple, and harmless. The investigation has been achieved by the direct application of a sterilized 8 MHZ, 5 mm Doppler probe on a small cortical artery. As the diameter has been exactly measured (0,8 mm +/- 0,2 in 15 cases) it is easy to calculate the blood flow from the recorded curve diagrams. The normal cortical flow of the sub millimetric arteries is about 2,52 cm3/mn +/- 1,16 confirming the previous data obtained with other methods of approach. The study of contused brains, points out, the disastrous effect of edema on cerebral blood flow, which before a complete arrest, looses its continuous diastolic pattern. Deep seated angiomas can be accurately located together with the flow direction in their feeding vessels. This method is also of fair interest for extra intra-crânial anastomosis, the choice of the cortical artery for bypass and its functional appreciation.
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Discography seems to have lost some interest for diagnosis in froomt of the new methods of myelo and radiculography with Metrizamide. But it remains still usefull before operation in some cases of lumbo-sciatic and cervico brachial pains. Beside the already known morphological disturbances of the disks it appeared very important to follow up the turnover of the contrast medium in the vertebral interspace. The turnover study of the contrast was performed by successives X ray views taken 12 hours, 24 hours and 48 hours after discography and also in some cases by the analysis of the half-life curve of a radioactive isotope (Technetium) injected jointly with the contrast in the disk. In the normal lumbar disk the contrast medium remains still visible after a delay of 24 hours, while it disappears completely at this time in cases of discopathy. This fact was also confirmed by isotope turnover. In cervical disk this information remains valuable but with a little shorter delay. This radiological sign remains trusty for the great majority of operated discopathies.
We examined 23 meningiomas by electron microscopy. In each case it was possible to distinguish certain cells with epithelial features (desmosomes, microfliaments, interdigitating extensions) and others with fibroblastic features (collagen fibers). Others cells of transitional form were also seen. The proportion of these cellular types is variable, making it possible to classify meningiomas into seven types of progressing gradually from a purely epithelial type to a purely fibroblastic one.-We found no important ultrastructural abnormalities in the cells. These case reports confirm the uniqueness of meningiomas, which are composed of variously shaped cells but have their origin from a single cellular type. This has double potentiality for fibroblastic and epithelial differentiation.
We have measured on semi-thin sections, the mitotic index in 5 benign gliomas and 5 malignant gliomas among a whole of about 80,000 cells in each group, divided into fields of 750 cells on an average. We have differentiated between normal mitoses and abnormal mitoses on one hand, between viable and adequate mitoses and non-viable mitoses on the other. If we take into account the total number of mitoses, the mitotic index is not greatly different between the 2 groups of tumors (about 5 per thousand), although slightly superior in the benign gliomas. If we take into account the viable or adequate mitoses only, the mitotic index is greatly superior among the benign gliomas. These results are discussed according to other data related with the kinetics of proliferation of gliomas and according to the possibility of cellular fusions as a process of a minor spreading of malignant gliomas.
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These data emphasize the interest of the study, in acute traumatic comatose, of the brain-stem reflexes and level of coma (Plum, Posner, Perez-Dominguez, Barge, Espagno) and the monitoring of the intracranial pression (ICP) by extra-dural screw (Vries, de Rougemont, J. Brunon). It is possible to describe: 1)The bilateral hemispherical contusions: with cortico-subcortical level and bilateral decorticate comatose. The normal brain-stem reflexes (N.B.S.R.) are presents. The monitoring of ICP allows to separate the reversible bilateral hemispherical contusions (ICP can present unstable recording during 3 days with pressure-waves--B waves--or to be stable (between 10--15 mm Hg)), from the severe bilateral contusions with rostro-caudal evolution and "plateau-waves". 2) The brain-stem contusions: the clinical level is often a mesencephalic level with decerebrate rigidity and N.B.S.R. +/- (Automatic Eye Movements). In severe injury the ICP is increased and unstable with A waves. In reversible brain-stem contusions the ICP is often stable and low with arteriography and ventriculography insignificant. 3) The associated contusions: In general, the head injuries of this group are alternatively decorticate or on decerebrate rigidity ("ambiguous reaction"). In the severe associated contusions the ICP shows A waves. In reversible contusions ICP is stable with normal supratentorial angiogramm and ventriculography.
We have compared the cell coat of benign gliomas and of malignant gliomas, by Ruthenium Red staining in vitro and by Thiéry's cytochemical reaction in situ. The thickness of the cell coat is not significantly increased by malignancy on the free surfaces of glioma cells. But in malignant gliomas only the cell coat disappears on the intercellular contact zones. These modifications are related to cell fusion characteristics of malignant transformation.
A few cell lines and primary monolayer cultures were accidentally infected by bacteria. These cultures were successfully decontaminated by means of the specific bacteriophage virus after quick identification of the responsible bacteria. This method presents a practical interest for preservation of valuable cultures.
In certain forms of atypical sciatic pain the surgical treatment of the affection cannot be accomplished exclusively upon the disk. This study was done on 120 patients operated upon during a two year period. The major technics used had an action upon the articular processes and facets with or without removal of the disk. In 60 cases a desensibilisation of the region was equally done. The principal reason of the surgical treatment remains still to permit the decompression of the sick root. In certain circumstances a more important surgical treatment is required: laminectomy is performed in cases of stenosis or in other cases an inter body fusion by posterior approach (60 patients). The term atypical lombo-sciatic pain is applied essentially when there exists discordancy in the clinical and neuroradiological examination. Surgical cure is applied when the medical treatment has failed. The best results have been obtained in atypical sciatic pain when facet rhizolysis has been associated with root decompression. However great care was taken to prevent the act from being destructive.
The authors report 6 cases of fracture and dislocation of the lower lumbar vertebrae (L3, L4, L5) and note that they were usually lesions following violent trauma usually in hyperflexion. The following were treated 1 dislocation L3-L4, 2 dislocations L4-L5, 2 comminuted fractures of L4, 1 fracture of L5, and included in all cases intersomatic arthrodesis at one (five cases) level or two levels (one case) and one posterior internal fixation with Kempf's material. The simplicity of the follow up and the stability of the fixation, permit us to propose the method for all unstable lesions of the lower lumbar vertebrae.
The use of posterior osteosynthesis in traumatic pathology of the dorso-lumbar spine, entails some throught about the time maintenance of the quality of the reduction and the solidity of equipment. The observation of the advantages and inconveniences of different methods has led us to the double shroud technique. The simultaneous use of Harrington's and Roy Camille's materials gives an excellent reduction from all points of view. Moreover the double shroud technique improves the stability of posterior osteosynthesis.
7 human multiform glioblastoma have been transplanted into the brain of 100 new born Mice. Electron microscopy and chromosome analysis confirm the growth of a human tumor showing malignant features of glioblastoma.
In severe spinal cord trauma with initial complete paraplegia or tetraplegia, even the smallest recovery of sensibility to pain or motor function has an obvious prognostical value as it results from the study of 112 spinal injuries. For the motor aspect it is well known from experimental work and in man that even a small part of a single pyramidal tract in the spinal cord can take in charge the bilateral motricity of the limbs. It remains exceptional in severe spinal cord injury that recovery of motricity is not followed by a return of pain sens. In the lateral funiculus of the cord the sensitive and pyramidal tracts belongs to a same anastomotic vascular area between the central and peripherical circulatory streams. In physiological conditions this intermediate circulatory stream is poorly functional. But in severe spinal cord trauma with reduction of central blood flow the adjacent spinothalamic and corticospinal tracts survive in couple on the basis of the same anastomotic vascular area: from this results the prognostical unity that belongs to pain sens and motricity.
A method of combined direct embolization of submillimetric cortical arteries, after preoperative arteriography, is described and 3 cases of cerebral angiomas presented with striking symptomatic improvement after embolization. Postoperative angiography in one case showed considerable diminution in the size of the angioma.