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Biomedical subjects

B Vrhovac

Publications and source records attributed to B Vrhovac.

At least 37 records · Page 2Linked to original sources
PubMed1985

A multinational comparison of drug treatment in patients with cerebrovascular disease.

We have compared the frequency with which various drugs were used in patients with cerebrovascular disease in five countries (UK, Italy, Indonesia, Spain and Yugoslavia). There were very large variations in the use of anti-oedema agents, 'cerebral vasodilators', and vitamins, which were not explained by differences in the populations studied. This variation has probably less to do with any scientific validation for the various treatments, which in most cases does not exist, than with medical 'fashion' and commercial pressures. Large variations in prescribing habits for what is thought to be the same disease are undesirable, and reflect a dearth of facts and adequate clinical trials.

Aged↗
PubMed1984

The P&T committee: Clinical Hospital Center, Zagreb, Yugoslavia.

A P&T Committee was recently founded and organized by clinical pharmacologists at the Clinical Hospital Center in Zagreb, Yugoslavia. Although subtle differences are evident, the responsibilities of the Yugoslav P&T Committee parallel those of the P&T Committees in hospitals in this country. A hospital formulary has been established in Zagreb's Clinical Hospital Center, resulting in more rational prescribing of drugs. The criteria for formulary inclusion and protocol for submission are provided. Other responsibilities of the Yugoslav P&T Committee in Zagreb are discussed.

Formularies, Hospital as Topic↗
PubMed1984

Electrocardiogram and high plasma digoxin concentration.

In 48 patients a significantly elevated plasma digoxin concentration (2.5 micrograms/l or more) correlated with the clinical symptoms and the electrocardiogram. The rhythm and conduction disturbances as well as the corrected Q-T interval and the P-T-Q index in the electrocardiogram were analyzed. In 23 patients rhythm and conduction disturbances were found. The clinical symptoms of digoxin overdose were found in 23 patients. There was no significant relationship between the corrected Q-T interval in the electrocardiogram and digoxin concentrations (r = 0.19); P-T-Q index and plasma digoxin concentrations were found to have similar values (r = 0.27), as did prolonged P-Q interval and plasma digoxin concentrations (r = 0.32). A total of 17 of 48 patients had had chronic renal failure. An S-T segment depression mostly of decreasing type was found in the whole group, suggesting that this sign was more reliable as an indicator of digitalis effect than corrected Q-T interval, P-T-Q index, or prolonged P-R interval.

Adult↗
PubMed1982

Comparison of the bioavailability of Redergin tablets (1.0 mg) and Redergin solution.

Pharmacokinetic investigations of Redergin LEK oral tablets (1.0 mg, dihydroergotoxine methanesulfonate) described in this article proved the efficacy of this pharmaceutical formulation. The properties of Redergin tablets almost completely correspond to results obtained when the active substance is applied as solution. The bioavailability of the formulation Redergin oral tablet is only a few percent lower than that of Redergin solution. A comparison with intravenous application of dihydroergotoxine methanesulfonate established that the bioavailability of Redergin oral tablet (1.0 mg) is 34% and Redergin solution 38%.

Adult↗
PubMed1981

Correlation between fluorimetric and microbiological methods for determination of cephalexin in urine and serum.

The fluorimetric and microbiological methods for the determination of serum and urine cephalexin were compared with the aid of coded samples in two different laboratories. The coefficient of correlation between the two methods for serum cephalexin was 0.94. At urine cephalexin concentrations above 0.5 g/l, the coefficient of correlations between two methods was 0.83. At lower concentrations (0.5 g/l), the coefficient of correlation was 0.72. It was concluded that the tested methods are comparable, equally sensitive and precise.

Biological Assay↗
PubMed1980

Aminophylline vs. salbutamol in exercise-induced asthma.

A comparative, double-blind, cross-over trial of aminophylline (6 mg/kg i.v.) and salbutamol (200 mcg per inhalationem) was conducted in six male patients (20 to 46 years) with exercise-induced asthma (EIA). Both aminophylline and salbutamol successfully prevented EIA. The serum concentration of theophylline was within the normal range (9.8--20.3 mcg/ml). The effect of salbutamol was slightly more pronounced than the effect of aminophylline but not statistically significant. Because of the more convenient method of application, the authors give priority to salbutamol in the prevention of EIA.

Adult↗