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Biomedical subjects

B W Larson

Publications and source records attributed to B W Larson.

5 recordsLinked to original sources
PubMed1987

Prostatic urethra: experimental dilation in dogs.

An animal study was undertaken to develop a balloon dilation technique that could be used in humans to treat the common ailment of benign prostatic hypertrophy. Dogs were used as a model because of the similarities in the prostate between the two species and the ready availability of the canines. A retrograde transurethral approach was used for dilation. Balloon catheters, 8-20 mm in diameter, were used. Significant, long-lasting dilatation of the prostatic urethra was not accomplished until 20-mm balloons (or two 10-mm ones) inflated for 10 minutes were used. The animals were followed for up to 14 months. No deleterious histologic effects of dilation were identified within the urethra or prostate that could lead to stenosis of the prostatic urethra in later stages.

Animals↗
PubMed1986

Hepatobiliary imaging: the diagnostic use of intravenous morphine in fasting patients.

Fasting and parenteral nutrition are associated with a spectrum of gallbladder disorders. We reviewed the use of hepatobiliary imaging in patients (N = 42) with fasting-induced gallbladder dysfunction. Intravenous morphine was administered in patients (N = 20) whose gallbladders did not visualize at 40 minutes after administration of diisopropyl iminodiacetic acid. In those patients whose gallbladders visualized with morphine (N = 8), the diagnosis of acute cholecystitis was excluded. Of those that did not visualize after morphine administration (N = 12), all were clinically diagnosed as acute cholecystitis. Although ultrasound is effective in demonstrating the anatomical features of prolonged gallbladder stasis including sludge, stones, and thickened gallbladder wall, it cannot detect cystic duct patency. Cholescintigraphy is an accurate test of cystic duct patency, but gallbladder stasis interferes with the ability of cholescintigraphy to visualize the gallbladder. From our experience, we propose that cholescintigraphy with intravenous morphine is beneficial in demonstrating cystic duct patency in fasting patients.

Acute Disease↗