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Biomedical subjects

B W Neville

Publications and source records attributed to B W Neville.

At least 19 recordsLinked to original sources

Oral neurofibrosarcoma associated with neurofibromatosis type I.

One of the most feared complications of neurofibromatosis type I (NF-I) is development of cancer, which is estimated to occur in about 5% of cases. The most common associated malignancy is the neurofibrosarcoma (NFS). HOwever, oral NFS in association with NF-I has rarely been reported. We report two cases of oral NFS arising in patients with NF-I. Both patients died of their tumors. Oral NFS arising in association with NF-I appears to have an extremely poor prognosis, as do these tumors at other sites of the body.

Adult

Myospherulosis. Report of a case.

A case of myospherulosis, a condition first reported in 1969, is reported following the extraction of mandibular third molars and subsequent placement of Terra-Cortril and Gelfoam into the extraction sites. The lesions were discovered during a periodontal surgical procedure and to the best of our knowledge this is the first such report in the periodontal literature.

Administration, Topical

Labial salivary gland tumors.

A study was conducted on labial salivary gland tumors from four oral pathology laboratories. Of the 103 identified tumors, 87 (84.5%) were from the upper lip, whereas 16 (15.5%) were from the lower lip. Of the 87 upper lip tumors, 80 (92.0%) were benign. Forty-three of these were monomorphic adenomas and 37 were pleomorphic adenomas. Seven malignant tumors of the upper lip were as follows: four adenoid cystic carcinomas, two acinic cell carcinomas, and one adenocarcinoma. Of the 16 lower lip tumors, 15 (93.8%) were malignant. Thirteen of these were mucoepidermoid carcinomas and two were acinic cell carcinomas. The only benign lower lip tumor was an intraductal papilloma. These results confirm the findings of previous investigations, showing that minor salivary gland tumors are much more common in the upper lip than the lower lip, but that lower lip tumors are more likely to be malignant.

Adolescent

Dentinal candidiasis in cancer patients.

Two examples of an unusual presentation of oropharyngeal candidiasis in cancer patients are offered. The light and scanning electron microscopic appearances of candidiasis involving the dentin of teeth are described. The potential significance of recognition of this form of candidiasis in cancer patients is discussed.

Adenoma, Pleomorphic

Eccrine spiradenoma: report of a case.

A case of eccrine spiradenoma of the lip is presented. This benign lesion of the eccrine sweat glands must be considered in the differential diagnosis of solitary or multiple soft tissue lesions of the head and neck. Final diagnosis is dependent on histologic examination. Carcinomatous transformation has been reported in eight cases, especially in those tumors of long duration.

Adenoma, Sweat Gland

The prevalence of benign fibro-osseous lesions of periodontal ligament origin in black women: a radiographic survey.

A radiographic study was conducted to determine the prevalence of benign fibro-osseous lesions of periodontal ligament origin (BFOLPDLO) in black women. Of 491 black women with both a panoramic radiograph and a full or partial periapical series, thirty-eight or 7.7% (age-adjusted rate = 7.7%) exhibited BFOLPDLO. Of these thirty-eight patients, twenty-nine had what is clinically recognized as periapical cemental dysplasia, for a prevalence of 5.9% (age-adjusted rate = 5.5%). The combination of a panoramic radiograph and a full or partial periapical series appeared more sensitive in the detection of BFOLPDLO than a panoramic radiograph or full series alone.

Adult

Histologic fate of dermal grafts following implantation for temporomandibular joint meniscal perforation: a preliminary study.

A study was carried out to evaluate the histologic changes of meniscus perforation repair associated with dermal grafts to the temporomandibular joint of cynomolgus monkeys (Macaca fascicularis) following surgical perforation of the meniscus. Dermal grafts were studied histologically at 3-week, 6-week, 3-month, and 6-month intervals. Results showed early attachment of the dermal graft to the meniscus, followed by gradual incorporation of the graft into the meniscus and subsequent return of the meniscal-graft complex to a normal meniscal architecture.

Animals

Pyostomatitis vegetans.

Pyostomatitis vegetans is a rare and unusual disorder of the oral cavity, characterized by erythema and edema of the mucosa and numerous small, superficial yellow pustules. Its significance lies in its association with inflammatory disease of the bowel, either ulcerative colitis or Crohn's disease. We report here a patient with pyostomatitis vegetans who, upon medical workup, was discovered to have asymptomatic Crohn's disease. The clinical features, histopathology, and treatment of pyostomatitis vegetans, and its purported relationship to pemphigus vegetans of Neumann are discussed.

Biopsy

The laterally positioned odontogenic keratocyst. A case report.

An odontogenic keratocyst which was in a lateral periodontal location is reported. The histology of the odontogenic keratocyst is compared with that of the lateral periodontal cyst. The importance of correctly diagnosing the odontogenic keratocyst is stressed, especially in view of its high recurrence rate and its possible association with the basal cell nevus syndrome.

Epithelium

The lateral periodontal cyst. A report of 37 cases.

The lateral periodontal cyst is a developmental cyst of odontogenic origin which is located along the lateral aspect of a tooth root. Thirty-seven previously unreported lateral periodontal cysts ( LPCs ) are presented. Clinical, roentgenographic and histologic features of the LPC are reviewed. Further, the importance of distinguishing the developmental LPC from laterally positioned inflammatory cysts of pulpal or periodontal disease origin and laterally occurring odontogenic keratocysts is stressed.

Adult

Oral melanoacanthoma. Review of the literature and report of ten cases.

Melanoacanthoma is a simultaneous benign proliferation of two cell types--the keratinocyte and the melanocyte. It is a rare lesion; only twenty cases have been reported on skin and three cases intraorally. This article reports a series of ten cases of intraoral melanoacanthoma. Significant clinical differences exist between skin and mucosal lesions. Whereas the skin lesions occur almost exclusively in white persons and in an older population, the mucosal melanoacanthoma occurs in a much younger population, is seen almost exclusively among blacks, and is frequently associated with a history of trauma or irritation which precedes the rapid development of the lesion. Several cases have resolved with incomplete removal. It is conjectured that this lesion may represent a reactive phenomenon on oral mucosa rather than neoplasia.

Adolescent

Histologic study of a freeze-dried skin allograft in a human. A case report.

HISTOLOGIC EXAMINATION at 6 weeks of a freeze-dried skin (FDS) allograft used to treat a mucogingival defect in the human revealed a striking prominence of elastic fibers within the graft, when compared to the adjacent gingiva and alveolar mucosa. This finding suggests that these fibers were retained from the donor material. The absence of a significant inflammatory infiltrate and the clinically normal healing that was observed indicates that FDS allografts are biocompatible with human oral tissue.

Female

Glomus tumor (golomangioma) of the tongue. A light and electron microscopic study.

A rare case of an intraoral glomus tumor on the ventral surface on the tongue was studied by light and electron microscopy. With light microscopy, the tumor was composed of dilated vascular channels surrounded by "epithelioid" glomus cells exhibiting large round nuclei and abundant eosinophilic cytoplasm. Bodian stains showed significant staining for nerve fibers among the tumor cells. Electron microscopic study demonstrated that the tumor cells had ultrastructural features which were similar to both smooth muscle cells and endothelial cells, suggesting that a "transitional" cell may give rise to glomus tumor. The literature on oral glomus tumors is briefly reviewed.

Female