[Recent knowledge in the pathophysiology, pathogenesis and hemodynamics of arterial hypertension as a base for scientifically founded diagnosis and therapy].
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Biomedical subjects
Publications and source records attributed to B Wedler.
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On the basis of investigations of the water and electrolyte balance, of the protein balance, the lipid metabolism and the hormone metabolism at the instance of aldosterone a concept of specific dialysis-conditioned pathophysiological disturbances is developed in patients undergoing a chronic programma of dialysis. The changes of metabolism induced by apparative therapy have a decisive influence on the pathophysiological mechanisms in the uraemic organism and condition a specific pathophysiology of the patient undergoing dialysis.
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A neurographic examination of 54 patients with essential hypertonia did not reveal any significant differences, from a control group, in the maximum rate of motor conduction of the ulnar nerve. An assocation of subclinical neuropathy with essential hypertonia cannot, therefore, be confirmed, thus denying the statement made by Viskoper and his coworkers and saying that the motor nerve conduction speed was an objective index for determining the severity of diseases characterized by hypertension.
When pathophysiological and pathogenetic aspects of hypertension are taken into consideration with special regard to diabetes mellitus the exhaustion of the "insulin enhancement" within the cerebrovisceral functional systems (Baumann) are discussed and the authors enter possible connections of diabetes mellitus to the renin-angiotensin-aldosterone system. After explanation of the diabetogenic and antidiabetogenic pharmacodynamic qualities of the antihypertensive drugs adequate therapeutic recommendations are proposed summarized in a figure. The authors conclude that for the present antihypertensive therapy in diabetics taking into consideration the references reported on there are sufficient possibilities of treatment for all degrees of severity of hypertension. Such preparations as Rausedan, Disotat, Dopegyt appear as particularly suitable; moreover, the beta receptor blockers, Haemiton, Depressan as well as Guanitil and Pargylin prove to be possible or without disadvantage, respectively. Especially when diuretics are described an exact control of the metabolism should be carried out.
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