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Biomedical subjects

B Weiner

Publications and source records attributed to B Weiner.

15 recordsLinked to original sources
PubMed1992

Color Doppler mapping of aortic regurgitation in aortic stenosis: comparison with angiography.

Color flow Doppler mapping has become the principal noninvasive method used for the qualitative grading of aortic regurgitation (AR). However, the performance of the color Doppler method in patients with AR accompanying aortic stenosis (AS) has not been studied. We therefore compared results of color Doppler and semiquantitative angiographic grading of AR in 32 patients with AS (mean valve area = 0.7 cm2) undergoing supravalvular aortography in the course of cardiac catheterization. Color Doppler demonstrated AR in all 27 patients who had AR by aortography. As expected, neither the maximal jet area nor the jet length discriminated patients by angiographic grade. The best correlation between color Doppler and aortography occurred when the ratio of maximal jet height (JH) to left ventricular outflow tract (LVOT) height was used to grade AR on a scale of 0-4. Four of 5 patients without AR by aortography had either absent or grade 1 AR by color Doppler. Although there was considerable overlap of color Doppler grades in patients with 1+ AR by aortography, grade 3 or 4 AR by color Doppler was always associated with III+ or IV+ AR by aortography. Thus, color Doppler sensitively depicts AR in patients with AS, and the ratio of JH to LVOT height by color Doppler correctly identifies patients with III+ or IV+ AR by aortography. Methods for distinguishing among milder grades require further evaluation.

Aortic Valve↗
PubMed1979

Differing effects of acid versus neutral phosphate therapy of hypercalciuria.

Studies were performed on 12 patients with idiopathic hypercalciuria to evaluate the hypothesis that the acid load accompanying potassium acid phosphate would adversely affect renal calcium reabsorption and citrate excretion compared to the neutral form of the phosphate salt. During acute clearance studies, neutral phosphate (NP) led to a fall in FECa (2.2 +/- 0.6% to 0.8 +/- 0.1%, P less than 0.02) and no change in titratable acidity (TA) or net acid excretion (NAE). Acid phosphate (AP) did not reduce FECa acutely, and led to a rise in TA (22 +/- 4 to 62 +/- 6 muEq/min, P less than 0.02) and NAE (46 +/- 6 to 6 89 +/- 7 muEq/min, P less than 0.02). During chronic administration, AP resulted in higher urinary calcium excretion in both absorptive (187 +/- 29 vs. 141 +/- 18 mg/day, P less than 0.02) and renal hypercalciuric patients (233 +/- 24 vs. 173 +/- 190.02 mg/day, P less than 0.02). Also, TA and NAE were higher following AP, whereas citrate excretion was lower (375.4 +/- 64.6 vs. 633.4 +/- 28.8 mg/day, P less than 0.01). These data suggest that the reported ineffectiveness of AP in the therapy of nephrolithiasis may be related to the deleterious effects of the acid load on calcium and citrate metabolism.

Acid-Base Equilibrium↗
PubMed1979

The new mental health code.

Explore the source record for details and available documents.

Commitment of Persons with Psychiatric Disorders↗
PubMed1978

Rapid treatment of percodan addiction: a case report.

This is a case study of narcotic addiction in which the patient was completely withdrawn from 12 to 20 Percodan tablets daily within 7 days. Signs and symptoms of the Abstinence Syndrome were minor and required minimal medication for their control. In addition, no electroshock treatment was necessary, nor were any other narcotic or other drug substituted for the Percodan.

Adult↗
PubMed1978

Effects of attributions for success and failure on the performance of retarded adults.

Seventy-two TMR adults were given success and failure experiences at a coding task, as well as one of three causal attributions (ability, effort, or task difficulty [ease]). The data revealed that causal ascriptions interacted with outcome in influencing speed of performance and that success enhanced performance only when coupled with an ability ascription. The data suggested that some of the contradictions in the success-failure literature may be due to differential causal attributions elicited across the various investigations. The implications of these data for training programs also were discussed.

Achievement↗
PubMed1976

Stability of gentamicin sulfate injection following unit dose repackaging.

The potency of gentamicin sulfate following repackaging in disposable syringes were determined by a modification of the agar diffusion bioassay, using a highly gentamicin-resistant strain of Psuedomonas aeruginosa to assay milligram quantities of active drug. Three factors were studied at 30, 60 and 90 days: (1) syringe character (glass vs plastic); (2) temperature (25 C vs 4 C); and (3) volume of aspirated sample. Glass syringes were superior at all time intervals. Storage in plastic for even 30 days resulted in unacceptable loss of potency (greater than 15%) and formation of a brown precipitate. Mass spectrophotometry indicated that this precipitate consisted mainly of esters of phthalic acid (plasticizer) and methylparaben (gentamicin preservative). Temperature had no effect on retained potency. A positive correlation between the percent potency lost and volume of gentamicin aspirated was demonstrated in both glass and plastic.

Drug Packaging↗
PubMed1975

Occupational lead nephropathy.

Among eight subjects suspected of excessive occupational exposure to lead, detailed examination of renal function identified abnormalities in four. Glomerular filtration rate was less than 87 ml/mim/1.73 m2 in one subject with asymptomatic renal failure, and in three subjects with preclinical renal dysfunction. In the subject with asymptomatic renal failure, chelation therapy increased the glomerular filtration rate, p-aminohippurate (PAH) extraction, the maximal PAH secretion rate (TmPAH) and improved proximal tubule ultrastructure, despite decreased renal plasma flow. This improvement in PAH transport was associated with correction of a proximal tubule defect in tritiated PAH uptake detected by section freeze-dry autoradiography of renal biopsy specimens. In three subjects, the etiologic diagnosis of lead-induced nephropathy was established by exclusion, but tubular dysfunction did not obviously exceed the reduction in blomerular filtration. Proximal tubule abnormalities were seen in each of the three patients who underwent biopsy. These studies suggest that lead nephropathy may be an important occupational hazard in the United States lead industry.

Aminohippuric Acids↗
PubMedDate not supplied

Radionuclide imaging of the heart in myocardial infarction and acute ischemia by 99mtechnetium diphosphonate.

99mtechnetium diphosphonate was used in 81 patients for myocardial imaging. 46 of the patients suffered, 2-6 days prior to the test, from an acute transmural infarction provided by clinical, ECG, and enzymatic evidence; the scintigram was definitely positive in 43, equivocal in 2, and negative in 1. In 16 patients with subendocardial infarctions, in 9 the scintigram showed a positive result, in 1 it was equivocal, and in6 patients negative. In 6 other patients who suffered from acute chest pain, followed by enzyme changes, but no ECG evidence of infarction throughout the hospitalization period, the scan was positive in all. In 13 patients with acute ischemia (unstable 'crescendo' angina), 9 had a positive, 1 an equivocal, and 3 a negative scan. We conclude that radionuclide imaging is a valuable addition to the methods already available for diagnosis of myocardial infarction. With the use of diphosphonate as the tracer, we found that acutely ischemic myocardium that later may recover, gives also positive imaging.

Adult↗