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B Weissman

Publications and source records attributed to B Weissman.

40 records · Page 3Linked to original sources

Effect of intervertebral changes of the spinal trabecular and cortical mineral content on the precision requirements in longitudinal single and dual energy computed tomography examinations.

Statistical considerations related to the measuring and analyzing procedures in computed tomography (CT) scans indicate that determination of a 2.5% change in spinal mineral content (SMC) which is assumed necessary in clinical practice, requires a 0.9% combined precision in setting the location and direction of the scan plane through the vertebral body, and defining the region of interest. In single energy examinations the short-term precision of CT scanners was found to be sufficiently high to achieve this goal, but the variability due to subjective finding of scan direction requires the automation of slice selection and additional averaging of data from more than one scan slice. The precision of calcium images was much lower, and one conclusion of this study is that dual energy technology is not suitable for longitudinal examinations, where small changes in SMC have to be determined. The SMC of the vertebrae T12, L1, L2, and L3 as measured in 41 subjects was compared and a significant decrease in trabecular bone in single energy examinations and increase in cortical bone was found from T12 to L3. This suggests that the comparison of SMC data should be done over time for each vertebra separately, in order to preserve diagnostic information.

Adult↗

Use of parenteral medium-chain triglyceride emulsion for maintaining seizure control in a 5-year-old girl with intractable diarrhea.

Medium-chain triglycerides (MCT) are an important component of an enteral ketogenic diet for seizure control. Previously, it was difficult to maintain ketosis when parenteral (iv) nutrition therapy was necessary. The use of iv MCT in a 5-year-old girl with Lennox-Gastaut syndrome who had diarrhea and dehydration is reported. Conventional 20% iv fat emulsion (long-chain triglycerides, LCT) and dextrose free hyperalimentation (HAL) in a 4:1 ketogenic ratio did not maintain adequate ketosis during bowel rest. Compassionate use of iv MCT (Clintec Nutrition) infused as a 70:30 MCT/LCT ratio plus HAL maintained moderate ketosis. Seizures were well controlled during the iv MCT regimen, which allowed normal daily functioning. Complications included abnormal liver function tests and severe iron deficiency anemia of unknown etiology. Serum triglyceride and cholesterol levels increased to 1717 mg/dl and 614 mg/dl, respectively, but decreased with a reduction of lipid infusion and use of an antihyperlipemic drug. Nutritional status was maintained. In this case, iv MCT proved to be a relatively safe and effective short-term method of continuing parenteral nutrition while maintaining ketosis for seizure control.

Acute Disease↗