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Biomedical subjects

B Wenger

Publications and source records attributed to B Wenger.

9 recordsLinked to original sources
PubMed1993

Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat.

Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42 degrees C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7 degrees C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the 1st HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats.min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration.

Administration, Oral↗
PubMed1983

Precocious in vitro development of satellite cells from dystrophic chicken muscle.

Satellite cells, liberated from pectoral muscle of juvenile dystrophic chickens by sequential treatment with collagenase, hyaluronidase, and trypsin and preplated to remove fibroblasts and cultured on gelatin proliferated rapidly, fused and formed confluent muscle cultures within 6 d in vitro with minimal contamination by fibroblasts. When identical isolation and culturing techniques were applied to muscle from age-matched normal chickens proliferation and differentiation were slower, contamination with fibroblasts was much greater, and only a small number of myotubes were formed. After injection of the myotoxic anesthetic marcaine into normal pectoral muscle for 5 consecutive days, myotube formation was accelerated in satellite cell cultures, but the rate of differentiation was not as rapid as that occurring in cells from dystrophic muscle.

Animals↗
PubMed1979

[Antibiotic therapy in odontogenic infections].

Antibiotic therapy for oral infections is described in the context of the determination of microorganisms involved and the formation of resistance to antibiotics. The indications are shown and in 115 cases the microorganisms responsible for the infection and their resistance are enumerated. It is alarming to know that increasingly multiple resistances to antibiotics are discovered. This increase is particularly observed in Tetracyclin and Trimethoprim-Sulfamethoxazol. Finally antibiotic therapies in oral infections are recommended.

Abscess↗