[Intense physical exercise--excessive strain on the immune system?].
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Cytokines↗
Biomedical subjects
B Wollach
Publications and source records attributed to B Wollach.
[Lateral sinus thrombophlebitis].
Lateral sinus thrombophlebitis (LST) is an intracranial complication of otitis media. Its incidence has markedly decreased in the era of antibiotic therapy but mortality is still high. A 13-year-old girl presented with fever, ear discharge and torticollis. On the day of admission LST was diagnosed from the clinical presentation and CT-scan. She was operated immediately and intravenous antibiotics were administered. Despite the rapid intervention, the course was protracted, with recurrent events of septic pulmonary embolism. Despite internal jugular vein ligation, fever continued and anticoagulant therapy was begun. The possibility of LST should be considered in patients with ear discharge and fever. CT-scan enables early diagnosis of LST and MRI has a role in detecting additional intracranial septal foci. Surgical intervention should be early and aggressive. The efficacy of jugular vein ligation is unclear; anticoagulant therapy should be considered.
Adolescent↗
Balanced bone marrow globin synthesis in mideastern alpha-thalassemia.
Hematological data and globin synthesis studies in 8 alpha-thalassemic children whose parents are from various regions in the Middle East are reported. All patients were devoid of Hb H. 5 of them had mild anemia, hypochromia and microcytosis and their blood alpha-/non-alpha-globin radioactivity ratios ranged between 0.56 and 0.75. The other 3 patients were hematologically normal with blood radioactivity ratios between 0.77 and 0.88. Bone marrow studies showed balanced globin chain synthesis for 6 of the patients and relatively more alpha-globin synthesis than in the blood for the remaining 2. The decrease in the relative synthesis of alpha-globin on erythroid cell maturation may relate to the molecular basis of alpha-thalassemia in the Middle East.
Bone Marrow↗
Increased renal threshold of bicarbonate due to carbon dioxide retention associated with proximal renal tubular acidosis.
We report a neonate who manifested type II (proximal) renal tubular acidosis (RTA). Hypoventilation secondary to hypothalamic dysfunction led to carbon dioxide retention. The consequent changes in acid base regulation are detailed and discussed.
Absorption↗