Biomedical subjects
Publications and source records attributed to B Wood.
A young woman presented with pellagra. Dietary intake of niacin was in excess of recommended guidelines. She had a low body mass index and was taking a number of alternative remedies. Resolution was rapid with oral nicotinic acid and discontinuation of the remedies.
Salivary cortisol profiles (hourly sampling over a 16-hour period) of 10 patients with chronic fatigue syndrome (CFS) but without concurrent depressive disorder were compared with those of 10 healthy volunteers matched for age, sex and menstrual cycle. The mean saliva cortisol concentration over the 16-hour period was slightly but significantly greater in the patients than the controls (p < 0.05). These findings are at variance with earlier reports that CFS is a hypocortisolaemic state and suggest that in CFS the symptom of fatigue is not caused by hypocortisolaemia.
Steroids have been discovered previously in oral "herbal" preparations. Using liquid chromatography, we have now confirmed the presence of the potent topical steroid, clobetasol proprionate, in a Chinese herbal cream.
Explore the source record for details and available documents.
AIMS: To document a nosocomial outbreak of Trichophyton tonsurans infection in a long stay ward. METHOD: Retrospective review of mycology cultures taken from patients and staff during 1993-5 and clinical examination of both patients and staff. RESULTS: Thirty-three mycology samples from 13 patients and staff, cultured T tonsurans during the period 1993-5. Twenty-two patients and staff were examined; 4 had mycology confirmed T tonsurans (2 scalp, 2 fingernail). Treatment with terbinafine 250 mg/day for 2 months resulted in clinical clearance (only 1 positive culture in 16 months follow-up). SUMMARY: T tonsurans is emerging as an important pathogen which may cause nosocomial infections.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Emulsifiers are an uncommon cause of allergic contact dermatitis. Five cases of allergic contact dermatitis to cetostearyl alcohol are presented. In all five cases, multiple positive reactions to other allergens were present, usually topical corticosteroid creams.
To compare the costs of prenatal care, labor and delivery, and postnatal care of 775 high-risk (HR) pregnancies with costs of 2,825 low-risk pregnancies, data were collected from retrospective chart review and computerized financial records of infants and mothers. Claims paid to providers, hospitals, and ancillary services were the direct medical costs of care for Sentara Health Plan. The total prenatal, labor and delivery, and postnatal costs were more than 6 million dollars and 3.5 million dollars for premature and term babies, respectively. Postnatal and total costs were related inversely to gestational ages and birth weights and directly related to length of stay. The data indicate the substantially increased cost of identified HR pregnancies. The gestational age and birth weight correlate with postnatal and total costs.
It is 70 years since Adolf Schultz urged his colleagues to consider how studies of primate growth and development could help them interpret the course of human evolution. This paper considers the evolutionary context of comparative growth studies. It compares and contrasts aspects of the ontogeny of living modern humans and chimpanzees, and considers whether relatively simple models of heterochronic change can account for the modifications which have taken place during the course of human evolutionary history.
The common ancestor of modern humans and the great apes is estimated to have lived between 5 and 8 Myrs ago, but the earliest evidence in the human, or hominid, fossil record is Ardipithecus ramidus, from a 4.5 Myr Ethiopian site. This genus was succeeded by Australopithecus, within which four species are presently recognised. All combine a relatively primitive postcranial skeleton, a dentition with expanded chewing teeth and a small brain. The most primitive species in our own genus, Homo habilis and Homo rudolfensis, are little advanced over the australopithecines and with hindsight their inclusion in Homo may not be appropriate. The first species to share a substantial number of features with later Homo is Homo ergaster, or 'early African Homo erectus', which appears in the fossil record around 2.0 Myr. Outside Africa, fossil hominids appear as Homo erectus-like hominids, in mainland Asia and in Indonesia close to 2 Myr ago; the earliest good evidence of 'archaic Homo' in Europe is dated at between 600-700 Kyr before the present. Anatomically modern human, or Homo sapiens, fossils are seen first in the fossil record in Africa around 150 Kyr ago. Taken together with molecular evidence on the extent of DNA variation, this suggests that the transition from 'archaic' to 'modern' Homo may have taken place in Africa.
Explore the source record for details and available documents.
This study provided the first empirical description of child and interviewer behaviors occurring within semistructured assessment interviews with children suspected of being victims of sexual abuse. Specifically, relationships between child and interviewer characteristics and interview credibility were examined. Using the Child Abuse Interview Interaction Coding System (CAIICS, Wood, 1990), 55 videotaped interviews of high-risk sex abuse cases seen at a multidisciplinary assessment center were behaviorally coded. Support was found for the interrater reliability and criterion related validity of the CAIICS was found. Results also revealed that children were initially rated as relaxed and displayed few emotional behaviors. Thus, the assumption that a credible disclosure of abuse must necessarily include the display of emotion by the child was not supported. Second, several behavioral differences between preschool and school-aged children were identified: however, no meaningful gender differences were found. Third, supporting evidence was found for both age and gender effects in judgments of interview credibility, with girls and school-aged children judged as more credible. Fourth, while the interviewer did engage in so called leading behaviors, these behaviors were not found to be related to rating of interview credibility. However, interviewer behaviors may have affected interview credibility through an intervening variable. Finally, implications, for further use of the CAIICS for examining interviewer-child interactions, evaluating standards of practice, and assisting with interviewer training are discussed.
Explore the source record for details and available documents.
Medicament allergies in patients with chronic leg ulcers is well recognized. In the past, topical antibiotics, rubber additives and wool alcohols have been the most common reported allergens. Allergy to topical corticosteroids has been reported. We document two cases of multiple corticosteroid allergy in patients with chronic leg ulceration.
Explore the source record for details and available documents.
Explore the source record for details and available documents.