It has been demonstrated in our previous papers that in the anterior part of medial basal hypothalamus (AM BH) in sheep a stimulating, while in the caudal part of MBH (CMBH) an inhibiting centre of prolactin release are situated. These results suggested that CMBH might be the site of PIF production and prompted us to investigate the effect of dopamine (DA) on the concentration of prolactin in the peripheral blood (p.bl.) in animals in which CMBH had been previously lesioned and this concentration was very high. Microinfusion of L-dopamine into the third cerebral ventricle (c.v.) or into the internal maxillary artery in intact as well as in lesioned lactating ewes depressed distinctly the prolactin level in the p.bl. This action of DA suggests that in the CMBH exists dopaminergic system which itself plays an inhibitory role in the control of prolactin release without involvement of PIF.

Animals↗

PubMedDate not supplied

[Changes in blood lipids after stroke in patients treated with lipanthyl].

The authors analysed the effectiveness of Lipanthyl treatment in 38 patients after stroke undergoing rehabilitation treatment. The effects of the drug were evaluated on the general condition, neurological and psychic status, progression of motor rehabilitation, and on lipid metabolism parameters. A statistically significant improvement was obtained in the subjective and psychic condition, and the results of motor rehabilitation were slightly better than in the compared groups of patients. Lipid metabolism was normalized only in part (cholesterol, chylomicrons). In the conclusions the authors state that it is useful to give this drug to patients with cerebral atherosclerosis only if disturbances of lipid metabolism coexist with this disease and are refractory to dietetic treatment.

Adult↗