Fusobacterium necrophorum septicemia in a lamb: pathologic and microbiologic characterization.
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Biomedical subjects
Publications and source records attributed to B Yamini.
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The efficacy of dietary tamoxifen (TAM) to alleviate the hyperestrogenic effects of the mycotoxin zearalenone (ZEN) was assessed by pathologic examination of the reproductive organs of female mink (Mustela vison). Mink were fed 20 mg/kg ZEN, 10 mg/kg TAM, or 20 mg/kg ZEN + 10 mg/kg TAM from about 2 mo prior to breeding until the kits reached 3 w of age. All female mink fed ZEN mated, but only 25% whelped. No mink fed TAM or TAM + ZEN mated. Postmortem examination revealed moderate to severely distended uteri filled with caseated necrotic substances in the TAM, ZEN and ZEN + TAM fed mink. Histologic examination revealed mild to severe endometrial hyperplasia to uterine atrophy, endometritis, metritis and pyometra. Ovarian follicles were atrophied and degenerated. TAM was not effective in alleviating the hyperestrogenic effects of ZEN but was a potent estrogen agonist in mink.
This report describes the clinical, microscopic, and ultrastructural findings in mink with muscular sarcocystosis. Three 2-3-mo-old mink were killed because they were ill with signs of progressive neurological disease. One mink had variable numbers of sarcocysts in multiple skeletal muscles. Sarcocysts were up to 300 microm in long and 20 microm wide. Ultrastructurally, the sarcocyst wall had numerous elongated 1.7-2.0-microm x 250-nm villar protrusions (VP). The VP had microtubules and irregularly distanced minute undulations. Both metrocytes and bradyzoites were present in sarcocysts. The mink with sarcocysts in muscles also had nonsuppurative meningoencephalitis and meningomyelitis. Similar brain lesions were found in other 2 mink from the same farm, but sarcocysts were not observed in the skeletal muscle of these animals. This is the first report of muscular sarcocystosis in mink.
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This report focuses on the diagnostic laboratory and necropsy findings in 4 llamas with adenovirus-associated hepatitis or pneumonia. In the 2 young llamas, clinical illness was characterized by chronic respiratory tract disease. In the 2 adult llamas, clinical illness was characterized by neurologic signs and a history of respiratory tract disease. Histologic examination, electron microscopy, virus isolation, and fluorescent antibody results indicated that adenovirus infection was associated with disease in all 4 llamas.
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Selenium toxicosis was diagnosed in feeder pigs on a central Michigan farm. Use of a commercial supplement, found to contain approximately 20 times the intended Se concentration, resulted in a Se concentration of 8.1 mg/kg of the complete feed. This was fed for 34 days during which daily feed consumption decreased approximately 35%, several pigs developed weakness and forelimb paresis, and 1 pig died. The highest serum Se concentration measured was 1,550 ng/ml (normal range, 140 to 190 ng/ml). Normal feed consumption returned when an alternative feed was provided. Mean serum Se concentrations of representative pigs, monitored over the subsequent 26 days, decreased from 905 to 258 ng/ml. Histologic examination of a recovering pig revealed skeletal and cardiac myopathy and bilaterally symmetric malacia of the gray matter of the ventral horns of the spinal cord. During the developing toxicosis, the pigs consumed an estimated 11.4 mg of Se/pig/d.
A severe outbreak of dairy herd pregnancy wastage was investigated. At the beginning of the outbreak, a total of 121 lactating cattle were pregnant and considered to be at risk. Overall, 33.1% of the population at risk aborted, while 25.6% gave birth to calves that either died during the early neonatal period or demonstrated signs compatible with congenital defects (abnormal births). A laboratory diagnosis of bovine viral diarrhea virus (BVDV) infection was made in two surviving neonatal calves with symptoms of cerebellar hypoplasia and blindness. An on-farm investigation was conducted to determine if the abortions and abnormal births were associated with BVDV infection. The rate of abortions versus abnormal births was biphasic when graphed by the date of occurrence. The cases of abortion occurred early in the outbreak and were followed by the neonatal losses. Within the population at risk, the mean values for gestational age at the beginning of the outbreak were different between the subpopulations described by gestational outcome. The outcome of each pregnancy that existed at the beginning of the outbreak was determined. Classifications included normal birth (birth of a normal calf), abnormal birth (a neonatal loss of the type described above), abortion, and continued gestation (normal, uncompleted pregnancy). The average gestational age at the time of the index case (the first cases of pregnancy wastage) for these four pregnancy outcome classfications was 142.0, 106.2, 86.7 and 31.3 days, respectively. Reasons for assuming that this outbreak was related to BVDV are discussed.
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Vitamin E deficiency was found to be the cause of reproductive failure and nutritional myodegeneration in a rabbit breeding colony. The diagnosis was based on the low vitamin E concentration of doe liver (5.73 micrograms/g) associated with myodegeneration of tongue, skeletal muscle, and heart and the absence of other abnormal microbiologic and parasitologic findings. Supplementation of the diet with wheat germ oil returned the does' fertility to normal, and abortion, stillbirth, and neonatal death ceased.
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Diarrhea in a Border Terrier was associated with inflammatory lesions of the myenteric plexus. This lesion has been documented rarely in dogs. It is speculated that the myenteric plexus lesions were responsible for an autonomic nervous system dysfunction, which resulted in extreme intestinal hypermotility and subsequent diarrhea. Suggested tests for dogs suspected to have autonomic dysfunction are given.
A 2-month-old Standard-bred colt with signs of abdominal pain and large scrotum was found to have septic periorchitis involving the right testis. Surgical exploration of the abdomen and scrotum was performed; the colt was then castrated. Actinobacillus equuli was isolated from specimens obtained at surgery. The colt was treated with broad-spectrum antibiotics and flunixin meglumine after surgery, and fully recovered. The clinical signs of periorchitis in the colt were similar to an inguinal/scrotal hernia.
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