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B Z Chikunova

Publications and source records attributed to B Z Chikunova.

At least 19 recordsLinked to original sources
PubMed2003

[Changes in the liver in glutenic enteropathy].

AIM: To evaluate frequency of clinical manifestations, biochemical and morphological alterations characteristic of liver affection in patients with glutenic enteropathy (GEP) in correlation with GE duration and severity of malabsorption syndrome (MAS). MATERIAL AND METHODS: 116 GEP patients have undergone clinico-laboratory examination, intestinoscopy with biopsy of jejunal mucosa, puncture biopsy of the liver with morphological examination of the specimens, ultrasonography of the liver. In addition, the immune status was assessed and tests for markers of hepatotropic viruses B and C were made. RESULTS: Clinical symptoms, typical for hepatic lesion in GEP patients, such as yellowness of the skin and scleras, palmar erythema, vascular stella and hepatomegaly were found in 7.2% cases. Hyperaminotransferasemia was detected in 48.4% of new cases of celiac disease, in 18.1% of patients on strict aglutenic diet. Aminotransferase hyperactivity detection was associated with severity of MAS. Morphological alterations in the liver in celiac disease are characterized by fat dystrophy, portal and periportal hepatitis, steatohepatitis or fibrosis. Combined therapy of celiac disease including strict aglutenic diet, correction of metabolic disturbances was not always effective in correction of metabolic processes in the liver. In new GEP cases early adequate therapy was most effective. CONCLUSION: The course of glutenic enteropathy is accompanied with clinicomorphological alterations in the liver. This necessitates use of drugs improving liver function.

Adolescent↗
PubMed2002

[Hemorrhagic shock. A new concept of endoscopic hemostasis and prospects of the non-surgical treatment of ulcer and gastroduodenal hemorrhages complicated by hemorrhagic shock].

A new direction with the use of endoscopic hemostasis (EH) was offered in the complex program of metabolic rehabilitation of patients with ulcerous gastroduodenal bleedings (UGDB) and hemorrhagic shock (HS). There was a study of the results of treatment of 44 patients (29 men and 15 women at the age from 61 to 77) with severe concurrent diseases and UGDB complicated with HS. Recurrences of UGDB in case of HS are a factor of high operative-anesthetic risk. Endoscopic preventive metabolic hemostasis is a prospective direction in rehabilitation of patients with UGDB complicated with HS. It is necessary to improve the EH methods for treatment of continued arterial bleedings from giant gastroduodenal ulcers.

Aged↗
PubMed2002

[General variable hypogammaglobulinemia].

The purpose of the paper was studying the features of course and treatment of common variable hypogammaglobulinemia (CVHG), proceeding with intestinal function disorders functions.

Antibody Formation↗
PubMed2002

[Role of stress in the etiopathogenesis of duodenal ulcer in young patients].

The analysis of the acid-forming function of the stomach, both basal and stimulated with insulin, atropine test, tests for the content of the adrenocorticotropic hormone, somatotropic hormone, thyrotropic hormone, triiodothyronine, thyroxin, cortisol in the blood and the content of gastrin in the blood and gastric juice, activity of the processes of lipid peroxidation, content of ceruloplasmin in the blood, content of Helicobacter pylori (Hp) in the gastric mucosa were conducted in 68 men and 64 women at the age from 18 to 40 years suffering from gastroduodenal ulcer in order to examine the role of stress in ulcer formation. 38 patients with duodenal ulcer took proton pump blockers and antioxidants for 3 years whenever they were in a stress situation. The research revealed that young patients with duodenal ulcer show enhanced sensitivity of parietal cells and sympathoadrenal system to stressful situations, and stimulation of the acid-forming stomach function takes place under the effect of both catecholamines and gastrin. Men can have both Hp-dependent and Hp-independent duodenal ulcers, while women have mostly Hp-dependent duodenal ulcers. Prescription of proton pump blockers of and antioxidants for patients with duodenal ulcer, who are in a stressful situation, reduces the frequency of duodenal ulcer recurrences.

Adolescent↗
PubMed2001

[Comparative diagnostic value of data of intestinoscopy with biopsy obtained from different regions of the small intestine].

AIM: To study diagnostic value of intestinoscopy with biopsy of the mucosa from different portions of the small intestine in patients with chronic diarrhea and malabsorption. MATERIAL AND METHODS: The examination of 116 patients with chronic diarrhea and malabsorption (endoscopic and histological study of biopsy specimens from different portions of the small intestine) detected gluten enteropathy (n = 51), Wipple's disease (n = 8), general variable hypogammaglobulinemia (n = 11), lymphangioectasy (n = 9), lymphangiomatosis (n = 1), lymphoma (n = 2), amyloidosis (n = 3), eosinophilic gastroenteritis (n = 1), duodenoejunitis without atrophy (n = 7). 23 patients had normal mucosa of the small intestine. RESULTS: Pathological changes in the jejunum and duodenum were identical in glutenic enteropathy (GE), Wipple's disease (WD), variable hypogammaglobulinemia (VH) and amyloidosis. CONCLUSION: For diagnosis of GE, WD, VH and amyloidosis it is sufficient to take biopsy from distal duodenum. Spot biopsy from sites of lymphostasis or nodular lymphoid hyperplasia is most informative for identification of lymphangioectasy, lymphangiomatosis and small intestinal lymphoma. Pathological changes in the ileum in GE, WD, VH and amyloidosis indicate severe total lesion of the small intestine.

Adolescent↗
PubMed2001

[24-Hour pH monitoring for the evaluation of functional and morphological esophageal disorders in patients with duodenal ulcers].

The examination's results of the patients with duodenal peptic ulcer and gastroesophagus reflux at the same time are presented in this paper. The frequency of pathological esophagus's changes revealing with endoscopic and histological methods, as well as with 24 hours intraesophagus pH-monitoring is compared. The correlation of pathological refluxes quantity and the severity of esophagus mucosa changes were demonstrated.

Adult↗
PubMed1999

[The potentials of intestinoscopy and guided biopsy in the diagnosis of diseases of the small intestine].

AIM: To ascertain the role of intestinoscopy in diagnosis of small intestinal diseases. MATERIALS AND METHODS: Intestinoscopy with multiple topographic biopsies was made with SIF-10 device (Olympus) in 92 patients. RESULTS: Of 60 patients with absorption disorders, the diagnosis of gluten enteropathy (GEP), Whipple's disease (WD), general variable hypogammaglobulinemia (GVHG) and small intestinal diverticulum was established in 38, 3, 5 and 1 patients, respectively. 13 patients with mild malabsorption were free of the pathology. GEP, amyloidosis, intestinal lymphangiectasia were found in 5, 3 and 4 of 15 patients with exudative enteropathy. The rest had lymphoma, lymphangiomatosis, Crohn's disease. 11 patients with focal affections had Crohn's disease, polyps, GVHG or had only motor defects. Repeated intestinal hemorrhages in a few patients were due to adenocarcinoma, aberrant pancreas, intestinal or gastric erosions. CONCLUSION: Patients with malabsorption and exudative enteropathy had similar abnormalities in the small intestine and duodenum. Endoscopic biopsy from the distal duodenum is enough for diagnosis of GEP, Whipple's disease and GVHG. Intestinoscopy as well as x-ray imaging are effective in detection of focal lesions of the small intestine and sources of intestinal bleeding.

Adolescent↗
PubMed1993

[Whipple's disease].

Explore the source record for details and available documents.

Combined Modality Therapy↗
PubMed1992

[Gluten enteropathy].

The authors relate the results of 10 years of observations of 113 patients suffering from gluten enteropathy (GE) of the adults. In all the patients, the diagnosis was supported by the presence of hyper-regenerative atrophy of the small intestinal mucosa (total in 70% and subtotal in 30%). Metabolic disorders and cellular immunity were investigated. At the onset of the observations 70.7% of the patients demonstrated malabsorption, stage III gravity, and 29.3% stage II. It has been proved that permanent and strict adherence to the agluten diet and administration of corticosteroids in the most severe cases in combination with pathogenetic therapy of diarrhea and metabolic disorders permit attaining a steady clinical remission, improvement of normalization of the biochemical and immunological characteristics, a tendency toward normalization of the small intestinal mucosa, and even the recovery of its normal structure in part of the cases.

Adolescent↗
PubMed1981

[Method for the objective evaluation of the state of the esophageal mucosa in reflux esophagitis (based on target biopsy data)].

A method for objective evaluation of a complex of histological changes of esophageal mucosa is proposed for increasing the reliability of the diagnosis. The method is based on the determination of quantitative similarity of the histological changes detected in the patient with the reference ones. This enables the histomorphologist to overcome the difficulties encountered in determining the degree of intensity of the inflammatory process and to apply computer techniques to timely and correct diagnosis of reflux esophagitis.

Biopsy↗
PubMed1981

[Aberrant pancreas in the gallbladder].

Two observations of an aberrant pancreatic gland in the gallbladder wall revealed by histological examination of the surgical material are presented. In one case the aberrant pancreatic gland was represented by the exocrine part and ducts in the other by adenomyoma.

Adult↗
PubMed1980

[Changes in the liver after penetration of a stomach ulcer into it (experimental-morphologic study)].

Changes in the liver induced by gastric ulcer penetration were studied in 130 rats. The ulcers were reproduced by the Okaba's method. The penetration entails destruction of the liver capsule, with 4 zones being seen in the organ tissue: necrosis, demarcation, inflammation, necrobiosis and hepatocyte proliferation. Apart from the destructive processes the reparative processes in the parenchyma and in connective tissue develop already in early stages. Active proliferation of hepatocytes and biliary ducts results in the penetration into the granulation tissue of the ulcer fundus. Ulcer healing is followed by a complete recovery of the affected areas of the liver, but gastric commisures remain.

Animals↗