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B Zabłocki

Publications and source records attributed to B Zabłocki.

5 recordsLinked to original sources
PubMed1981

Influence of 6-metoxy-cumaranon-2-acetic acid and its derivatives on the process of humoral and cellular immunogenesis.

The influence of 6-metoxy-cumaranon-2-acetic acid and its four derivatives on the humoral and cellular immunogenesis was determined. The study of immunosuppressive properties included: the control of the level of peripheral blood lymphocytes, the estimation of transplantation immunity, GvH reaction, PFC production for SRBC and LPS and the determination of the number of cells possessing receptors for antigen, Fc fragment and complement. Furthermore, blast transformation of lymphocytes stimulated with PHA was estimated as well as the cytotoxic effect of sensitized lymphocytes. The results indicate immunosuppressive activity of acetamides HKCMF and HKCHF. They lowered the level of circulating lymphocytes, the number of cells possessing receptors for complement and they hindered PFC production for SRBC and LPS. Moreover, acetamide HKCHF weakened the cytotoxic activity of lymphocytes sensitized to alloantigens.

Animals↗
PubMed1978

The influence of aminoguanidine derivatives on the process of humoral and cellular immunogenesis.

The influence of six aminoguanidine derivatives on the process of humoral and cellular immunogenesis was examined. The obtained results can be presented in the following items: 1. Strong action inhibiting the primary humoral response was found in mice of Balb/c strain where the decrease of PFC number in spleen was from 34.8% to 96.7%; only the second preparation (D-mannose-ylidene-aminoguanidine) (HCl) caused a significant increase of PFC number and thus, on the contrary, exerted the action stimulating the humoral immunological response. 2. Among the examined preparations only three (third, fourth and fifth) showed the action inhibiting MIF production (the decrease within 30-50%) and only these three preparations caused a clear prolongation of allograft survival in the pattern: Balb/c-recipient, C3H-skin graft donor. 3. The clear decrease of the number of lymphocytes in peripheral blood was found (within 40-60%) as a result of administering aminoguanidine derivatives. 4. Synergism was not found to occur when administering jointly ALS and aminoguanidine derivatives, with the aim of prolonging allograft survival or inhibiting MIF production.

Animals↗