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B Zakharieva

Publications and source records attributed to B Zakharieva.

14 recordsLinked to original sources
PubMed1990

[Thyroid hormone dynamics during the thyrostatic treatment of Basedow's disease].

The efficacy of the generally accepted therapeutic scheme was studied in 52 newly discovered and untreated patients with Basedow's disease with the purpose to clarify the frequent failures of the thyrostatic treatment. The thyroid hormones levels were determined in dynamics initially and in the course of the disease. The results show that the efficacy of the thyrostatic drugs is individually different and depends on the supersensitivity of the thyroid gland. The remission occurred on the average on the 50th day--considerably earlier than the usually expected time limit. In order to study the expedience of the therapeutic scheme applied, the active dose required by the scheme was continued. As a result in the 4 month after the beginning of the treatment the thyrotropic hormone increased to a mean level of 35.7 mU/l--hypothyroid value. A monthly control of the thyroid hormones levels during the course of the active treatment is necessary and a reduction of the doses of the thyrostatic drugs when a remission is achieved must be performed.

Adolescent↗
PubMed1989

[The TRH test using the Bulgarian preparation Protilerin in the diagnosis of hyperthyroidism].

The stimulation test--TRH test was carried out with the Bulgarian drug "Protilerin" in 63 patients (Basedow's disease--53 patients, basedoid goiter--5 patients, infiltrative ophthalmopathy--5 patients) and in 20 healthy controls. The healthy controls showed normal reaction to the stimulation. All patients with hyperthyroidism showed a suppressed response to the stimulation. In two of the patients with euthyroid infiltrative ophthalmopathy the response was similar to that of the healthy controls. The Bulgarian drug Protilerin is suitable for the performance of the TRH test in the diagnosis of hyperthyroidism.

Adult↗
PubMed1988

[Dynamic thyroid hormone levels during the thyrostatic treatment of Basedow's disease].

The thyroid hormones and thyrotropic hormone levels were followed up dynamically in the course of thyrostatic treatment in 24 newly discovered patients with Basedow's disease. The following findings deserve special attention: 1. The early appearance of therapeutic remission--mean after 2.4 months of treatment, 2. The increase of the thyrotropic hormone following soon after remission is achieved--mean at the end of the forth month of treatment it reaches 19.5 mIU. The analysis revealed that this high mean level was due to 9 patients who had reacted with initial hypothyroidism though they were under the same therapeutic conditions. The data allow the conclusion that there are individual differences in thyroid suppressibility. This implies a dynamic follow up of the thyrostatic hormonal action and timely correction of the dose which would remove the consequences of improper dosage.

Adult↗
PubMed1987

[Basal blood level of thyroxine in diabetes mellitus patients].

An insignificant lower mean blood level of T4 in diabetics versus healthy subjects was established on the base of the studies performed to 136 patients with diabetes mellitus. The slight tendency to decrease of T4 showed no dependence on sex, age, light bi-directional deviations from the standard body mass, duration and type of diabetes and differences in the drug treatment. The dependence between glycemia and blood thyroxine is poor. The lower level of blood thyroxine in the patients with nephropathy is very likely, a sequela of the existing nephropathy. A tendency to normalization of T4 blood level was observed with the compensation of diabetes.

Adult↗
PubMed1987

[Tests for determining thyroid function].

The diagnostic possibilities of the basic radio-immunological methods for the determination of thyroid function were studied in 316 healthy subjects and 235 patients with diseases of thyroid gland. The indices with the most significant diagnostic value in hyper- and hypothyroidism were derived on the base of a comprehensive analysis of the individual data. After a re-evaluation of the functional tests for the thyroid gland known so far, a strategy was elaborated, making use only of radio-immunological tests for the thyroid function.

Adult↗
PubMed1986

[Parathyroid hormone values in patients on chronic dialysis treatment].

It has been stressed that the values of radioimmunologically determined PTH in patients on chronic dialysis treatment are considerably high and the duration of dialysis treatment has no marked effect on them. Relatively good correlation dependence between the serum levels of calcium and PTH is established only in the presence of hypocalcemia. In all other cases the correlation dependence between PTH and calcium as well as that with phosphorus and alkaline phosphatase is negligible so that their serum values cannot be used to judge the level of PTH. The dynamic follow up of the PTH values is emphasized to be performed with one and the same kit, hence avoiding the methodical errors.

Adult↗
PubMed1985

[Age and thyroid function (radioimmunologic study)].

Radio-immunologic study on the hormones of hypopheseal-thyroid axis was performed in 207 healthy subjects, aged from 0 to 79, namely: thyroxine (T4), triiodothyronine(T3) revrese T3 (rT3), thyrotropic hormone (TTH), thyroxine-binding globulin (TBG) and the index of free thyroxine was calculated (IFT4). Considerably elevated levels of thyroid indices were established at birth and only rT3 and TTH were normalized during the early neonatal period. The thyroid indices were also kept higher during the period of childhood and adolescence as compared with the mature and old age. A tendency was observed to a constant decrease of the levels of T3 and TBG with age advancing.

Adolescent↗
PubMed1978

[Total thyroxine level in human serum].

Eighteen healthy subjects and 42 patients with diseases of the thyroid gland were examined. Total thyroxin in serum was determined in all, by past StaT4 (Oxford laboratories) and according to the method of Murphy and Pattee, modified by Benotty and Peno. Thyroxin values obtained, by the two methods, were similar and correlated well with the subjects' clinical state. Certain advantages of paste StaT4 were established, making it more applicable in clinical practice as compared with the procedure of the modified method of Murphy and Pattee.

Humans↗