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Biomedical subjects

B Zgorzalewicz

Publications and source records attributed to B Zgorzalewicz.

At least 19 recordsLinked to original sources
PubMed1983

The pattern of myelin proteins in triethyltin (TET) intoxication.

Myelin proteins isolated from the brain of Wistar rats intoxicated chronically with triethyltin sulfate (TET) according to the technique of ETO et al. (1971) were investigated. Among the various protein fractions, the Agraval protein happened to be most evidently affected, demonstrating considerably reduced percentages. However the results did not prove that any of the individual myelin proteins was specifically affected by TET intake. The interesting point in chronic TET poisoning was that some clinical symptoms as well as disturbances in myelin proteins demonstrated a clear tendency to retrogression despite of the continued intoxication. These observations indicate obviously that during chronic TET intake, some kind of biochemical adaptation to the noxious action of the poison on the myelin sheath takes place.

Animals↗
PubMed1983

Myelin proteins in Wallerian degeneration of the optic nerve.

The development of changes in the protein spectrum of the rabbit optic nerve undergoing Wallerian degeneration was studied and compared with the time sequence of the previously established changes occurring in the lipid composition of the degenerating nerve. The myelin protein spectrum remained essentially unchanged till 32 days after enucleation to show a decrease of the relative content of basic myelin proteins accompanied by increased percentages of the Wolfgram protein during the forthcoming development of Wallerian degeneration. The occurrence of changes in the myelin protein spectrum was significantly delayed in comparison with the onset of enhanced esterification of myelin cholesterol, and thus the latter process, and not the hydrolysis of basic protein is considered as an early event, weakening the molecular structure of the myelin membrane that might initiate the demyelinating process.

Animals↗
PubMed1978

The effect of intoxication with alkylnitrosourea derivatives on cerebral myelin.

Adult BD IX rats were injected with methylnitrosourea and pregnant mice on the 15th day of gestation with a single intravenous dose of ethylnitrosourea and pregnant mice on the 15th day of gestation with a single intravenous dose of ethylnitrosourea. The cerebral myelin fraction of adult BD IX rats and of the mice offsprings was studied. It was found that a part of the rats intoxicated with methylnitrosourea developed spongious changes in the cerebral and cerebellar white matter. The myelin fraction of intoxicated rats also showed severe losses of sphingomyelin with a steady increase in the cholesterol ester content. The myelin fraction from mice intoxicated during the foetal development appeared deficient with respect to galactolipids and plasmalogen. It is concluded that, besides the carcinogenic effect, alkylnitrosourea derivatives effectively disturb the lipid metabolism of membrane structures of the central nervous system.

Animals↗
PubMed1977

Activity of acid: Co A ligase (AMP) in the course of experimental allergic encephalomyelitis.

In studies concerned with the activation of fatty acids, a metabolic step initiating the biosynthesis of fatty acids rendering them suitable for elongation, desaturation, esterification or degradation, we have demonstrated that the activity of acid: Co A ligase (AMP) -- E.C.6.2.1.3. is declined throughout the whole investigated period of experimental allergic encephalomyelitis (EAE). This observation clearly indicates that in this experimental disease it is not only the increased catabolism of lipid constituents furnishing the various membraneous structures, including myelin sheats, but also an overall impaired capacity of synthesing new lipids by the diseased cells of the nervous system which must be taken into consideration.

Animals↗