Biomedical subjects

Barbara Charbotel

Publications and source records attributed to Barbara Charbotel.

5 recordsLinked to original sources

PubMed2006

Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects.

To test the effect of the exposure to trichloroethylene (TCE) on renal cell cancer (RCC) risk, a case-control study was performed in the Arve Valley (France), a geographic area with a high frequency and a high degree of such exposure. Cases and controls were selected from various sources: local general practitioners and urologists practicing in the area and physicians (urologists and oncologists) from other hospitals of the region who might treat patients from this area. Blinded telephone interviews with cases and controls were administered by a single trained interviewer using occupational and medical questionnaires. The analysis concerned 86 cases and 316 controls matched for age and gender. Three approaches were developed to assess the link between TCE exposure and RCC: exposure to TCE for at least one job period (minimum 1 year), cumulative dose (number of p.p.m. of TCE per job period multiplied by the number of years in the job period) and the effect of exposure to peaks. Multivariate analysis was performed taking into account potential confounding factors. Allowing for tobacco smoking and Body Mass Index, a significantly 2-fold increased risk was identified for high cumulative doses: odds ratio (OR)=2.16 (1.02-4.60). A dose-response relationship was identified, as was a peak effect; the adjusted OR for highest class of exposure-plus-peak being 2.73 (1.06-7.07). After adjusting for exposure to cutting fluids the ORs, although still high, were not significant because of lack of power. This study suggests an association between exposures to high levels of TCE and increased risk of RCC. Further epidemiological studies are necessary to analyze the effect of lower levels of exposure.

Aged↗

PubMed2006

Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part I: Exposure assessment.

A method for a semi-quantitative retrospective assessment of exposure to trichloroethylene (TCE) was implemented for a case-control study conducted in the Arve valley (France), an area with a widely developed screw-cutting industry, where teams of occupational physicians have collected a large quantity of well-documented measurements. A task-exposure matrix was developed to link the main working circumstances in a screw-cutting workshop to corresponding TCE-exposure levels: a 'basic level' was assigned to each task, standing for usual working procedures; exposure circumstances, such as duration or distance from the TCE source, were introduced as corrective factors. In parallel, a detailed occupational questionnaire was designed, setting subjects' descriptions of their successive jobs and working circumstances against levels assessed in the matrix. Possible exposure to TCE, plus some other occupational compounds (other solvents, oils, some metals, asbestos, welding fumes and ionizing radiations), were assessed for any job in all job histories. An average level of exposure to TCE, related to an 8 h usual working day, was attributed to each job period in turn, which was then categorized into six classes: 0; 1-35; 35-50; 50-75; 75-100; and >100 p.p.m. A total of 402 study subjects described their occupational life (average 3.7 jobs/subject, from 1924 to 2003). About 19% of the 1486 job periods described were assessed as being exposed to TCE; of these, 72.2% involved levels<35 p.p.m., 13.2% involved levels>50 p.p.m. and 5.4% above the French occupational exposure limit of 75 p.p.m. (TWA 8 h). A total of 41 job periods included exposure with peaks. Compared with levels encountered in other studies, the more severely exposed part of our study population seemed more exposed than most other populations previously studied, owing to vapor degreasing practices.

Carcinogens↗

PubMed2004

Respiratory function among waste incinerator workers.

INTRODUCTION: Whereas air pollutants have been measured in incinerator working areas, few studies have focused on the effects of these pollutants on the lung function of incinerator workers. In France, a study was performed among workers at two urban incinerators, aimed at identifying a link between exposure to different pollutants in incinerator plants and respiratory lung function impairments. METHODS: A follow-up of lung function was carried out on 83 incinerator workers from two incinerator plants, comparing them with a group of 76 non-exposed workers recruited by the same occupational physician. Workers' lung functions were measured during their yearly occupational medical examination, for 3 years. The American Thoracic Society quality criteria were used to control the quality of the flow-volume curves. RESULTS: Base-line lung functions were lower among incinerator workers than among non-exposed workers. The few significant differences were indicative of obstructive symptoms. During the first year the differences observed between the two groups were close to the significant threshold value of 5% for FEF(75)/ PV and FEF(25-75)/PV. During the third year significant differences covered three parameters: FEF(50)/PV, FEF(25-75)/PV and FEF(25-75)/FVC. After smoking habits (pack-years), medical history of allergy or lung diseases and the examination centres had been taken into account in a linear regression, the reduction of FEF(75)/PV in the first year and FEF(25-75)/FVC in the third year was linked to exposure in incinerator plants. There was no significant association between exposure and the differences observed in the FEF(25-75)/PV in the first year or in the FEF(50)/PV and the FEF(25-75)/PV in the third year. CONCLUSION: This analysis of incinerator workers' lung functions has identified some lung impairments among workers exposed to incinerator air pollutants compared to non-exposed workers, thus indicating possible obstructive disorders among incinerator workers. However, these impairments are moderate and in accordance with the low levels of airborne pollutants identified in a previous study.

Adult↗

PubMed2003

Severity factors for truck drivers' injuries.

A study was carried out in 1995-1999 to assess severity factors for truck drivers' crashes. The authors used data from the trauma registry of road crash victims of the Rhône region, France. Several descriptive characteristics of the victims (age, place of residence) and their crashes (place, time, antagonist, seatbelt wearing) were analyzed. The injuries of 300 male truck drivers were described by body region, and their severity was measured by using the injury severity score comparing these drivers with 9,488 male car drivers (age: 18-67 years). Truck drivers were more seriously injured than car drivers; the odds ratio was 1.87 (95% confidence interval: 1.33, 2.63) for having an injury severity score of 9 or more. Limb and abdominal lesions were more frequent and more serious among truck drivers. The lack of seatbelt wearing by truck drivers was one of the factors that explained the particular severity of their injuries; the odds ratio, adjusted for seatbelt wearing, for truck drivers to be seriously injured was 1.04 (95% confidence interval: 0.73, 1.47) compared with car drivers. When all of the severity factors were taken into account, the risk was even lower, but not significantly so.

Accidents, Traffic↗

PubMed2003

Morbidity among municipal waste incinerator workers: a cross-sectional study.

OBJECTIVES: In order that the occupational exposures and health risks for municipal waste incinerator operators be better determined, a study was carried out in three centres. METHODS: A transversal study was carried out for 102 male incinerator workers matched for age with 94 male workers from other industrial activities. Three groups of exposed workers were considered (group 1: "crane operators" and "equipment operators"; group 2: "furnace " workers; group 3: "maintenance" and "effluent-treatment" workers). Data were collected through a questionnaire and medical examination. The respiratory function was explored and blood samples were taken for biological analysis. Statistical analysis using chi(2) or Student's test, and calculation of odds-ratio (OR) using logistic regression analysis were performed. RESULTS: There were no significant differences in general symptoms between the two groups. Skin symptoms (OR =4.85; 2.04-11.51 for the "maintenance and effluent" workers) were more often observed in the exposed group. An excess of respiratory problems was also encountered: daily coughing ["maintenance and effluent" groups (OR =2.55; 0.84-7.75); "furnace men" (OR =6.58; 2.18-19.85)]. A significant relationship between exposure and the decrease of several pulmonary parameters was observed. The liver and haematological tests were well within the normal range; nevertheless, a slight but significant increase in the white blood cells was observed in the exposed group. Higher blood lead levels were found for exposed workers. CONCLUSION: There were few adverse health effects in our morbidity study but skin irritation and cough were more frequent in the exposed workers. A slight decrease in pulmonary function was observed. These findings are in agreement with those of several other studies.

Accidents, Occupational↗